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The Human Detoxification System

Detoxification is a natural process inherent to the human body. Over time, our bodies accumulate a variety of toxins from our environment, food sources, and "silver" mercury amalgam tooth fillings: and as we accumulate more toxins, we become less effective at detoxifying ourselves. Efficient detoxification depends on a series of seamless reactions that bind toxins to shuttle molecules and “escort” them out through a series of doors. The glutathione system is the most important of the detoxification systems and includes glutathione and the enzymes that work with it. The detoxification process proceeds in three parts or “phases”, Phase I, Phase II, and Phase III. Dysfunction of the human detoxification system is the most common and insidious root cause of toxic element and compound accumulation in the body. True health requires that all phases function in balance, or the whole system can not work properly. Quicksilver Scientific's CEO & founder, Dr. Christopher Shade, Ph.D. is an expert in mercury research.

The Human Detoxification System

mercury in blood

Successful Detoxification

Successful Detoxification of Mercury and other Heavy Metals (e.g. lead, cadmium, arsenic) requires three Fundamental Conditions:

  1. Fully-functioning Phase III detoxification transport system (MRP1&2, OATP)
  2. Fully-functioning Phase II enzyme, Glutathione S-transferase (GST)
  3. Adequate intracellular glutathione levels

Quicksilver Scientific’s Therapeutic Detoxification System is the ONLY detox system that specifically targets all three detoxification requirements!

Disruptions in Natural Body-wide Detoxification

Intestinal inflammation

inhibits elimination of toxins by causing a strong down-regulation of the body’s natural detoxification pathways. Unfortunately, exposure to pesticides, chemicals and certain toxins, such as the corrosion by-products of dental mercury amalgam (”silver” fillings) contributes to intestinal inflammation. In addition to inflammation, it has been demonstrated that a build up of metals alone slows the transport proteins. The data suggests that continuous removal of metals from the intestines is essential for the proper daily functioning of natural detoxification processes. The continuous removal of metals is also critical for any successful practitioner-directed detoxification program.

Consequences of Impaired Detoxification

  • Downregulation of toxin transporters
  • Downregulation of Phase II detoxification enzymes
  • Underexpression of cellular antioxidants
  • Relative overexpression of oxidative Phase I enzymes
  • Systemic toxicity and oxidative stress!
  • Increased susceptibility to chronic disease!