Quicksilver Scientific

Due to high demand & labor shortages we are experiencing significant shipping delays. We greatly appreciate your patience. 

Search site wide
Search
0

Unsupported Browser

This website will offer limited functionality in this browser. We only support the recent versions of major browsers like Chrome, Firefox, Safari, and Edge.

30 Day Reset Program References

NAD+ Gold® References https://www.quicksilverscientific.com/nadgoldreferences/

[1] Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. View Abstract

[2] Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916 View Abstract

[3] Wu, L et al. The elusive NMN transporter is found. Nat Metab 2019: 1; 8-9  View Full Paper

[4] Rajman L et al. Therapeutic potential of NAD-Boosting molecules: The in vivo evidence. Cell Metab. 2018 Mar 6;27(3):529-547. View Abstract

[5] Li W et al. NAD+ Content and Its Role in Mitochondria. Mitochondrial Regulation. 2014: 39–48 View Abstract

[6] Lee CF et al. Targeting NAD+ metabolism as interventions for mitochondrial disease. Sci Rep. 2019 Feb 28;9(1):3073. View Abstract

[7] Schultz MB et al. Why NAD+ Declines during Aging: It’s Destroyed. Cell Metab. 2016 June 14; 23(6): 965–966 View Full Paper

[8] Davila, A et al. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 2018 Jun 12;7 View Full Paper

[9] Imai S. The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control. NPJ Syst Biol Appl. 2016 Aug 18;2:16018 View Full Paper

[10] Massudi H et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue PLoS One. 2012;7(7):e42357 View Abstract

[11] Zhu XH et al. In vivo NAD assay revels the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl. Acad. Sci. 2015; 112:2876–2881 View Full Paper

[12] Hershberger KA et al. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017 Apr;13(4):213-225. View Full Paper

[13] Gross CJ et al. Digestion and absorption of NAD by the small intestine of the rat J Nutr. 1983 Feb;113(2):412-20. View Abstract

[14] Poljsak B. NAMPT-Mediated NAD biosynthesis as the internal timing mechanism: in NAD+ World, time Is running in its own way. Rejuvenation Res. 2018 Jun;21(3):210-224 View Abstract

[15] Tsubota, K. The first human clinical study for NMN has started in Japan. NPJ Aging Mech. Dis. 2016, 2, 16021 View Abstract

[16] Strait, JE. Scientists identify new fuel-delivery route for cells. Washington University School of Medicine. Available at: https://medicine.wustl.edu/news/scientists-identify-new-fuel-delivery-route-for-cells/ Accessed: 9-14-2019

[17] Mills KF et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016: 24, 795–806. View Full Paper

[18] Anti-Aging compound in human clinical trial: will boosting NMN slow aging? Available at: https://hecmedia.org/posts/anti-aging-compound-in-human-clinical-trial-will-boosting-nmn-slow-aging-6/ Accessed 9-1-2019

[19] Guan Y et al. Nicotinamide Mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1-dependent manner. J Am Soc Nephrol. 2017 Aug;28(8):2337-2352. View Full Paper

[20] Martin As et al. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model.JCI Insight. 2017 Jul 20;2(14). View Full Paper

[21] Johnson S et al. NAD + biosynthesis, aging, and disease. F1000Res. 2018 Feb 1;7:132 View Full Paper

[22] Mills KF et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016; 24:795–806 View Full Paper

[23] Das A et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20 View Abstract

[24] Kathirvel E et al. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1068-77  View Full Paper

[25] Schmeisser K et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 2013;9(11):693–700. View Full Paper

[26] Bonkowski MS et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 November ; 17(11): 679–690 View Full Paper

[27] Kane AE et al. Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular disease. Circ Res. 2018 Sep 14;123(7):868-885. View Full Paper

[28] Sun WP et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. Clin Nutr, 2017. 36(4): p. 1136-1142 View Abstract

[29] Van der Meel R et al. Extracellular vesicles as drug delivery systems: lessons from the liposome field. J Control Release. 2014 Dec 10;195:72-85 View Abstract

[30] Yoshida M. Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice. Cell Metab. 2019 Aug 6;30(2):329-342.e5 View Abstract

[31] Yoshino J et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528 View Full Paper

[32] Gaddipati R et al. Visceral adipose tissue visfatin in nonalcoholic fatty liver disease. Ann Hepatol. 2010;9(3):266–70. View Abstract

[33] Revollo JR et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6(5):363–75 View Full Paper

[34] Caton PW et al. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated

[35] impairment of mouse islet function. Diabetologia. 2011;54(12):3083–92. View Abstract

[36] De Picciotto NE et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell 2016, 15, 522–530. View Full Paper

[37] Yoshino J et al. Nicotinamide mononucleotide, a key NAD (+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528–36 View Full Paper

[38] Uddin GM et al. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front. Pharmacol. 2016, 7, 258 View Full Paper

[39] Wei CC et al. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Sci. Rep. 2017, 7, 717 View Full Paper

[40] Wang X et al. Nicotinamide mononucleotide protects against –amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016, 1643, 1–9. View abstract

[41] Yao Z et al. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci. Lett. 2017, 647, 133–140. View Abstract

[42] Hou Y et al. NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc. Natl. Acad. Sci. USA 2018, 115, E1876–E1885 View Abstract

[43] Wei CC et al. NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia. Br J Pharmacol. 2017 Nov;174(21):3823-3836 View Full Paper

[44] Gomes AP et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013; 155, 1624–1638.View Full Paper

[45] Stromsdorfer KL et al. NAMPT-Mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice. Cell Rep. 2016 Aug 16;16(7):1851-60. View Abstract

[46] Camacho-Pereira J et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016; 23:1127–1139 View Full Paper

[47] Lin JB et al. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016; 17:69–85 View Full Paper

[48] Sheedfar F et al. Liver diseases and aging: friends or foes? Aging Cell. 2013 Dec;12(6):950-4 View Abstract

[49] Hamaguchi M. Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women.

[50] World J Gastroenterol. 2012 Jan 21;18(3):237-43 View Full Paper

[51] Day CR et al. Betaine chemistry, roles, and potential use in liver disease. Biochim Biophys Acta. 2016 Jun;1860(6):1098-106 View Abstract

[52] Zhao G et al. Betaine in inflammation: mechanistic aspects and applications.  Front Immunol. 2018 May 24;9:1070. View Full Paper

[53] Ueland PM et al. Betaine: a key modulator of one-carbon metabolism and homocysteine status.

[54] Clin Chem Lab Med. 2005;43(10):1069-75. View Abstract

[55] Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. View Abstract

 

AMPK Charge+ References https://quicksilverscientific.com/ampkchargereferences 

[1] Herzig S and Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018; 19(2): 121-135.

[2] Hardie DG, et al. Targeting an energy sensor to treat diabetes. Science. 2017; 357 (6350): 455-456.

[3] Foretz M and Viollet B. Activation of AMPK for a break in hepatic lipid accumulation and circulating cholesterol. EBio Medicine. 2018; 31: 15-16.  

[4] Tamargo-Gomez I, et al. AMPK: Regulation of metabolic dynamics in the context of autophagy. Int J Mol Sci. 2018; 19(12): 3812.

[5] Furman D, et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019; 25: 1822-1832.

[6] Jeon SM, et al. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016; 48: e245.

[7] Shirwany NA and Zou MH. AMPK in cardiovascular health and disease. Acta Pharmacol Sin. 2010; 31(9): 1075-1084.

[8] Ruderman NB, et al. AMPK, insulin resistance, and the metabolic syndrome. J Clin Investig. 2013.

[9] Seabright AP, et al. AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner. FASEB J. 2020; 34(5): 6284-6301.

[10] Ruderman NB, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010; 298(4): E751-E760.

[11] Pan H and Finkel T. Key proteins and pathways that regulate lifespan. J Biol Chem. 2017; 292(16): 6452-6460.

[12] Connell NJ, et al. NAD+ metabolism as a target for metabolic health: have we found the silver bullet? Diabetologia. 2019; 62(6): 888-899.

[13] Anton SD, et al. Flipping the metabolic switch: Understanding and applying health benefits of fasting. Obesity (Silver Spring).

[14] Fan W and Evans RM. Exercise mimetics: Impact on health and performance. Cell Metab. 2017; 25(2): 242-247.

[15] Dolinksy VW, et al. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. J Physiol. 2012; 590(Pt 11): 2783-2799.

[16] Konrad M and Nieman DC. Evaluation of quercetin as a countermeasure to exercise-induced physiological stress. antioxidants in sports nutrition. 2015.

[17] Kaeberlein M, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005; 280(17): 17038-17045.

[18] Park D, et al. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. Sci Rep. 2016; 6: 21772.

[19] Grant R. Resveratrol increases intracellular NAD+ levels through the up-regulation of the NAD+ synthetic enzyme nicotinamide mononucleotide adenylyltransferase. Nature Precedings. 2010.

[20] Csiszar A, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol.

[21] Sun H, et al. Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell Death & Dis. 2018; 9: 824.

[22] Lee YS, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Pharmacol & Ther. 2006; 55(8).

[23] Gomes AP, et al. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta. 2012; 1822(2): 185-195.

[24] Rayamajhi N, et al. Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 Cells. Oxid Med Cell Longev. 2013; 2013: 154279.

[25] Li Y, et al. Quercetin, inflammation and immunity. Nutrients. 2016; 8(3): 167.

[26] Kim SG, et al. Quercetin-induced AMP-activated protein kinase activation attenuates vasoconstriction through LKB1-AMPK signaling pathway. J Med Food. 2018; 21(2): 146-153.

[27] Lewinska A, et al. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. Redox Biol. 2020; 28: 101337.

[28] Van Deursen JM. Senolytic therapies for healthy longevity. Science. 2019; 364(6441): 636-637.

[29] Weng Z, et al. Quercetin Is more effective than Cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012; 7(3): e33805.

[30] Jiang K, et al. Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells. Oncol Rep. 2015; 33(6): 2711-2718.

[31] Lovelace ES, et al. Silymarin suppresses cellular inflammation by inducing reparative stress signaling. J Nat Prod. 2015; 78(8): 1990-2000.

[32] Ye Y, et al. 3,3′-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy. Biochem Pharmacol. 2016; 115: 77-84.

[33] Hornero RA, et al. The impact of dietary components on regulatory T cells and disease. Front Immunol. 2020; 11: 253.

[34] Shen Y, Honma N et al. Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMPactivated protein kinase signaling. PLoS One. 2014 Feb 14;9(2):e8789

[35] Park KR, Nam D. β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Lett. 2011 Dec 22;312(2):178-88

[36] Mollazadeh H and Hosseinzadeh H. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iran J Basic Med Sci. 2016; 19(12): 1258-1270.

 

QuintEssential® 3.3 References https://www.quicksilverscientific.com/hypertonicreferences/

[1] Holm NG, Anderson EM. Abiotic synthesis of organic compounds under the conditions of submarine hydrothermal systems: a perspective. Planet Space Sci 1995; 43(1-2): 153-9.

[2] He HZ, Li HB et al. Determination of vitamin B1 in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 2005; 383(5): 875-9.

[3] Litchfield CD, Hood DW. Microbiological assay for organic compounds in seawater. II. Distribution of adenine, uracil, and threonine. Appl Microbiol 1966; 14(2): 145-51

[4] Quinton, R. L’eau De Mer, Milieu Organique: Constance Du Milieu Marin Originel, Comme Milieu Vital Des Cellules, À Travers La Série Animale. Ulan Press. 2012

[5] Yoshizawa Y, Tanojo H et al. Sea water or its components alter experimental irritant dermatitis in man, Skin Res. Technol., 2001 (7): 36–39.

[6] Kimata H, Tai H et al.  Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS), Acta Med. (Hradec Kralove, Czech Repub.), 2002 (45): 2; 83–84.

[7] Tabary O, Muselet C et al. Reduction of chemokine IL8 and RANTES expression in human bronchial epithelial cells by a sea water derived saline through inhibited nuclear factor kB activation, Biochem. Biophys. Res.Commun., 2003 (309); 2: 310–316.

[8] Miyamura M, Yoshioka S et al. Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis, Biol. Pharm. Bull., 2004; (27): 11;  1784–1787.

[9] Slapak I, Skoupá J et al Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children, Arch. Otolaryn gol. Head Neck Surg., 2008 (134); 1:  67–74.

[10] Yoshioka S, Hamada A et al. Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 2003 Nov;26(11):1552-9.

[11] Armstrong LE, Ganio MS. Mild dehydration affects mood in healthy young women. J Nutr. 2012 Feb;142(2):382-8.

[12] Fadda R, Rapinett G. Effects of drinking supplementary water at school on cognitive performance in children. Appetite. 2012 Dec;59(3):730-7.

[13] Suhr JA, Hall J. The relation of hydration status to cognitive performance in healthy older adults.  Int J Psychophysiol. 2004 Jul;53(2):121-5.

[14] Lieberman HR. Hydration and cognition: a critical review and recommendations for future research. J Am Coll Nutr. 2007;26(5S)

[15] Paik IY, Jeong MH et al. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7.

[16] Texas Heart Institute: Trace Elements: what they do and where to get them. Available at: https://www.texasheart.org/. Accessed June 1, 2019.

[17] Scotney B, Reid S. Body weight, serum sodium levels and renal function in an ultra-distance mountain run. Clin J Sport Med. 2015 Jul;25(4):341-6.

[18] Hoffman MD, Joslin J et al. Management of suspected fluid balance issues in participants of wilderness endurance events. Curr Sports Med Rep. 2017 Mar/Apr;16(2):98-102.

[19] Armstrong LE, Johnson EC et al. COUNTERVIEW: Is drinking to thirst adequate to appropriately maintain hydration status during prolonged endurance exercise? No. Wilderness Environ Med. 2016 Jun;27(2):195-8.

[20] Angier, N. The wonders of blood. Available at: https://www.nytimes.com/2008/10/21/science/21angi.html. Accessed June 1, 2019.

[21] Theocharis AD, Skandalis SS et al. Extracellular matrix structure. Adv Drug Deliv Rev. 2016 Feb 1;97:4-27.

[22] Pischinger, A. The Extracellular Matrix and Ground Regulation: Basis for a Holistic Biological Medicine. North Atlantic Books; 2007.

[23] Nabaa A, Clauser KR et al. The extracellular matrix: tools and insights for the “omics” era. Matrix Biol. (2016) 49; 10–24

[24] Gomez C, Deravi L. Self-assembling extracellular matrix proteins as materials for the condensation of silica nanostructures. RSC Advances 2016 (97) ra/c6ra20911d

[25] Silkin VA, Pautova LA et al. Drivers of phytoplankton blooms in the northeastern Black Sea. Mar Pollut Bull. 2019 Jan;138:274-28

[26] Litchman E, Klausmeier CA et al. The role of phytoplankton functional traits in structuring phytoplankton communities: scaling from cellular to ecosystem level. Ecol. Lett. 2007(10); 1170–1181

[27] Winder M, Cloern JE. The annual cycles of phytoplankton biomass. Phil. Trans. R. Soc. 2010; B 365: 3215–3226

[28] Lemke KH, Rosenbauer RJ et al. Peptide synthesis in early Earth hydrothermal systems. Astrobiology 2009; 9(2):141-6.

[29] Khokhlov AN, Morgunova GV et al. Pilot study of a potential geroprotector, “Quinton Marine Plasma”, in experiments on cultured cells. Biological Sciences Bulletin, 2015; (70):1; 7–11.

[30] Alberola J, Coll F.  Marine therapy and its healing properties, Curr. Aging Sci., 2013; (6): 1; 63–75.

[31] Campos, M. Heart rate variability: A new way to track well-being. Harvard Health Publishing, Harvard Medical School. Available at: https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789. Accessed June 1, 2019.

[32] Presentation by Michael Kesller, DC. Quinton and the Extracellular Matrix. Available at: https://www.youtube.com/watch?v=XYFbuTQSjNo Accessed June 1, 2019.

[33] Ortells, JMS. Study of the Immunomodulatory Activity of QT solution in human PBMNc. Abstracts. 2nd European Congress of Immunology; European Journal of Immunology, Supp. 1/09

[34] Radhakrishnan G, Yamamoto M. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression. Biochem Biophys Res Commun. 2009 Sep 11;387(1):25-30.

[35] Dittman R. Bio-Terrain, evolutionary biology, and the practice of medicine in the early 1900’s: an intro to René Quinton’s marine plasma. Explore. 2006: (15):4

[36] Szent-Györgyi, A. Biology and pathology of water.  Perspectives in Biology and Medicine. 1971 (14);2 : 239-24f9.

 

Methyl Charge+ References https://www.quicksilverscientific.com/methylchargereferences/

[1] McKee SE et al. Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition: considerations for future research Nutrition Reviews, 2018 (75): 7:497-511 View Full Paper

[2] Williams AC et al. Nicotinamide, NAD(P)(H), and methyl-group homeostasis evolved and became a determinant of aging diseases: hypotheses and lessons from Pellagra. Curr Gerontol Geriatr Res. 2012;2012:302875. View Full Paper

[3] Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. View Abstract

[4] Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916 View Abstract

[5] Hershberger KA et al. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017 Apr;13(4):213-225. View Full Paper

[6] Tasselli L et el. Methylation gets into rhythm with NAD(+)-SIRT1Nat Struct Mol Biol. 2015 Apr;22(4):275-76 View Abstract

[7] Aguilar-Arnal L et al. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.Nat Struct Mol Biol. 2015 Apr;22(4):312-8. View Full Paper

[8] Cantó C et al. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 2015 Jul 7;22(1):31-53. View Full Paper

[9] Kang-Lee YA et al. Metabolic effects of nicotinamide administration in rats. J Nutr. 1983 Feb;113(2):215-21. View Abstract

[10] Aksoy S et al. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 1994 269, 14835–14840.

[11] Li W et al. NAD+ content and its role in mitochondria. Mitochondrial Regulation. 2014: 39–48 View Abstract

[12] Lee CF et al. Targeting NAD+ metabolism as interventions for mitochondrial disease. Sci Rep. 2019 Feb 28;9(1):3073. View Abstract

[13] Pelizzola M. The DNA methylome. FEBS Lett. 2011 Jul 7; 585(13): 1994–2000. View Full Paper

[14] Moore LD et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38.View Full Paper

[15] Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol. 2008;15(2):72–75. View Full Paper

[16] Friso S et al. One-carbon metabolism and epigenetics. Mol Aspects Med. 2017 Apr;54:28-36. View Abstract

[17] Shames DS, Minna JD et al. DNA methylation in health, disease, and cancer. Curr Mol Med 7: 85-102View Full Paper

[18] gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicol Sci. 2019 May 14. pii: kfz110 View Full Paper

[19] Ligthart S et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255 View Full Paper

[20] NIH U.S. National Library of Medicine, MTHFR gene. Genetics Home Reference Available at: https://ghr.nlm.nih.gov/gene/MTHFR Accessed 1-4-2020

[21] Castro R et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. Journal of Medical Genetics 2004;41:454-458View Full Paper

[22] Hustad S et al. Riboflavin and methylenetetrahydrofolate reductase. Madame Curie Bioscience Database [Internet]. View Full Paper

[23] Pinto JT et al. Riboflavin. Advances in Nutrition 2016 (5):5;973-975 View Full Paper

[24] O’Leary F. Vitamin B12 in health and disease Nutrients. 2010 Mar;2(3):299-316. View Full Paper

[25] James JS, Melnyk S et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1): 425–430 View Full Paper

[26] Belardo A et al. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children J Nutr Biochem. 2019 Aug;70:38-46. View Abstract

[27] Anderson OS e al. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation.J Nutr Biochem. 2012 Aug;23(8):853-9. View Full Paper

[28] Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35View Full Paper

[29] Chang CY et al. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41View Abstract

[30] Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93View Full Paper

[31] Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36View Full Paper

[32] Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811View Full Paper

 

H2 Elite References https://www.quicksilverscientific.com/h2elitereferences/

[1]Ohsawa I, Ishikawa M et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007 Jun;13(6):688-94

[2] Sauer H, Wartenberg M et al. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 2001 11, 173–186

[3] Liu H, Colavitti R et al. Redox-dependent transcriptional regulation. Circ. Res. 2005 97, 967–975

[4] Bjelakovic G. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013 Sep 6;8(9):e74558

[5] Apostolova N, Victor VM. Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal. 2015 Mar 10;22(8):686-729

[6] Ohta, S. A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease. Curr. Med. Chem. 2003 10, 2485–2494

[7] Turrens JF. Mitochondrial formation of reactive oxygen species. J. Physiol. (Lond.) 2003 552, 335–344

[8] Zhai X, Chen X et al. Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression Free Radic Biol Med. 2013 Dec;65:731-741

[9] Yu J, Zhang W. Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression Toxicol Lett. 2015 Nov 4;238(3):11-9

[10] Hara F, Tatebe J et al. Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.Circ J. 2016 Aug 25;80(9):2037-46

[11] Qiang Ma. Role of Nrf2 in oxidative stress and toxicit. Annu Rev Pharmacol Toxicol. 2013; 53: 401–426.

[12] Itoh T, FujitaY et al. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651–6

[13] Itoh T, Hamada N et al. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun. 2011;411(1):143–9

[14] Hayashida K, Sano M et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008;373(1):30–5

[15] Zhang Y, Sun Q et al. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol. 2011;148(1):91–5

[16] Zhang G, Gao S et al. Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats. Sci Rep. 2015;5:9858

[17] Shinbo T, Kokubo K et al. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Physiol Heart Circ Physiol. 2013;305(4):H542–50.

[18] Wood KC, Gladwin MT. The hydrogen highway to reperfusion therapy. Nat Med 2007 (13):6 673-674

[19] Ito M, Hirayama M et al. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamineinduced Parkinson’s disease in rats. Med Gas Res. 2012;2(1):15

[20] Zhang CB, Tang YC et al. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-kappaB signaling pathway. Exp Ther Med. 2015;9(6):2114–20

[21] Fukuda K, Asoh S et al. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun.2007;361(3):670–4.

[22] Shin MH, Park R et al. Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. PLoS One. 2013;8(4):e61696

[23] Yoon KS, Huang XZ et al. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biol Pharm Bull. 2011;34(11):1671–7.

[24] Ishibashi T, Sato B et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27

[25] Chen Q, Chen P et al. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013;40(6):857–63

[26] Xin T, Fang S. The role of hydrogen in Alzheimer’s disease. Med Gas Res. 2018 Oct-Dec; 8(4): 176–180

[27] Ichihara M, Sobue S et al., Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles. Med Gas Res, 2015. 5: 12

[28] Song G, Li M et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013 54(7), 1884–1893.

[29] Da Ponte A, Giovanelli N et al. Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness. 2018 May;58(5):612-621

[30] LeBaron TW, et al. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Can J Physiol Pharmacol. 2019; 97(9). [online].

 

Ultra Binder® References https://www.quicksilverscientific.com/ultrabinderreferences/

[1] Frolis VV, Nikolav VG et al. Effect of enteroabsorption on animal lifespan. Biomat. Art. 1989. 17(3): 341-351.

[2] Su W, Ding X. Methods of endotoxin detection. J Lab Autom. 2015 Aug;20(4):354-64

[3] Aitken AE, Richardson TA et al. Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol 2006: 46:123–149

[4] Bolder U, Ton-Nu HT et al. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997: 112:214–225.

[5] Cherrington NJ, Slitt AL et al. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug MetabDispos2004: 32:734–741

[6] Tang W, Yi C et al. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats. 2000 Mol Cell Biol Res Commun 4:90–97

[7] Maklad A, Emara A et al. Pediatric poisoning in Egypt. Journal of Applied Pharmaceutical Science, 2012 2 (2): 1-6.

[8] Khalid J, Zailaey A. Medical and environmental applications of activated charcoal: review article. European Scientific Journal January 2015 (11): 3: 50-56

[9] Neuvonen J, Olkkola KT. Oral activated charcoal in the treatment of intoxications: role of single and repeated doses. Med Toxicol, 1988: 3; 33-58

[10] Karnib M, Kabbani A et al. Heavy metals removal using activated carbon, silica and silica activated carbon composite. Energy Procedia 2014: 50, 113 – 120.

[11] Du XN, Niu Z et al. Effect of activated charcoal on endotoxin adsorption. Part I. An in vitro study. Biomater Artif Cells Artif Organs. 1987;15(1):229-35

[12] Dalefield R. Emergency care and stabilization of the poisoned patient. In: Veterinary Toxicology for Australia and New Zealand, 2017: 19-32

[13] Rodriguez-Reinoso. Activated carbon and adsorption. in Encyclopedia of Materials: Science and Technology, 2001: 22-24

[14] Krasopoulos JC, De Bari VA et al The adsorption of bile salts on lipids. 1980 May;15(5):365-70

[15] Neuvonen PJ, Kuusisto P. Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationships and comparison with cholestyramine Eur J Clin Pharmacol. 1989;37(3):225-30

[16] Musso CG, Michelangelo H et al. Combination of oral activated charcoal plus low protein diet as a new alternative for handling in the old end-stage renal disease patients Saudi J Kidney Dis Transpl. 2010 Jan;21(1):102-4

[17] Koide, S. S. Chitin-chitosan: properties, benefits and risks. Nutrition Research 1998;8(6):1091-1101

[18] Macchi G. A new approach to the treatment of obesity: chitosan’s effects on body weight reduction and plasma cholesterol levels. Acta Toxicol Ther 1996;17:303-320

[19] Lütjohann D, Marinova M. Nutrients. Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects. 2018 Jan 11;10(1)

[20] Maezaki Y, Tsuji K et al. Hypocholesterolaemic effect of chitosan in adult males. Biosc Biochem Biotech 1993;57:1439-1444

[21] Shoemaker, RC. (2001) Desperation Medicine. Gateway Press: Baltimore. 2. Shoemaker, RC, Schaller J, Schmidt P. (2005) Mold Warriors: Fighting America’s Hidden Threat. Gateway Press: Baltimore

[22] Karunasena E, Larrañaga MD et al. Building-Associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment. Mycopathologia. 2010 Dec;170(6):377-90

[23] Carretero MI. Clay minerals and their beneficial effects upon human health. A review. Appl Clay Sci 2002; 21: 155–63.

[24] Herrera P, Burghardt RC et al. Adsorption of Salmonella enteritidis by cetylpyridinium-exchanged montmorillonite clays. Vet Microbiol 2000; 74: 259–72

[25] Haydel SE, Remenih CM. J Broad-spectrum in vitro antibacterial activities of clay minerals against antibiotic-susceptible and antibiotic-resistant bacterial pathogens Antimicrob Chemother. 2008 Feb;61(2):353-61

[26] Schaumberger S, Ladining A et al. Evaluation of the endotoxin binding efficiency of clay minerals using the Limulus Amebocyte lysate test: an in vitro study. MB Express. 2014; 4: 1

[27] Bland, Jeffrey. Effect of orally consumed Aloe vera Juice on Gastrointestinal Function in Normal Humans. Preventative Medicine, March-April 1985

[28] Marzorati M. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol. 2010 May 15;139(3):168-76.

[29] Im SA, Lee YR et al. In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel. Arch Pharm Res. 2010 Mar;33(3):451-6.

[30] Visuthikosol V, Chowchuen B et al. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai. 1995 Aug;78(8):403-9

[31] Im SA, Oh ST et al. Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. International Immunopharmacology. 2005;5(2):271-279

[32] Hu Y, Xu J, Hu Q. Evaluation of antioxidant potential of aloe vera (Aloe barbadensis miller) extracts. J Agric Food Chem. 2003 Dec 17;51(26):7788-91

[33] Eshun, K., He, Q. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries—a review. Crit. Rev. Food Sci. Nutr. 2004: 44, 91–96

[34] Mohamed RE, Gadour MO. The lowering effect of Gum Arabic on hyperlipidemia in Sudanese patients. Front Physiol. 2015 May 18;6:160

[35] Crociani F, Alessandrini A et al. Degradation of complex carbohydrates by Bifidobacterium spp. Int.J Food Microbiol. 1994;24:199-210.

[36] Walter DJ, Eastwood MA et al. Fermentation of wheat bran and gum arabic in rats fed on an elemental diet. Br.J.Nutr. 1988;60:225-32

[37] Wyatt GM, Bayliss CE et al. A change in human faecal flora in response to inclusion of gum arabic in the diet. Br.J.Nutr. 1986;55:261-6.

0
Your Cart

cyber monday

SALE

25% OFF

USE CODE: CM25

25% OFF Site-Wide

USE CODE: BF25

Exclusions apply: Offer does not include the following products: All Detox Protocols (except Push-Catch), Bio-Age Reversal Protocol, 30-Day Reset, Quinton® and QuintEssential® products, Biocidin® LSF, Clearway Cofactors®, and H2 Elite®. Discount cannot be combined with any other offers, promotions, or coupons.