Free Shipping on Orders over $300 (Excludes , , )
30 Day Reset Program References
NAD+ Gold® References https://www.quicksilverscientific.com/nadgoldreferences/
[1] Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. View Abstract
[2] Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916 View Abstract
[3] Wu, L et al. The elusive NMN transporter is found. Nat Metab 2019: 1; 8-9 View Full Paper
[4] Rajman L et al. Therapeutic potential of NAD-Boosting molecules: The in vivo evidence. Cell Metab. 2018 Mar 6;27(3):529-547. View Abstract
[5] Li W et al. NAD+ Content and Its Role in Mitochondria. Mitochondrial Regulation. 2014: 39–48 View Abstract
[6] Lee CF et al. Targeting NAD+ metabolism as interventions for mitochondrial disease. Sci Rep. 2019 Feb 28;9(1):3073. View Abstract
[7] Schultz MB et al. Why NAD+ Declines during Aging: It’s Destroyed. Cell Metab. 2016 June 14; 23(6): 965–966 View Full Paper
[8] Davila, A et al. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 2018 Jun 12;7 View Full Paper
[9] Imai S. The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control. NPJ Syst Biol Appl. 2016 Aug 18;2:16018 View Full Paper
[10] Massudi H et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue PLoS One. 2012;7(7):e42357 View Abstract
[11] Zhu XH et al. In vivo NAD assay revels the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl. Acad. Sci. 2015; 112:2876–2881 View Full Paper
[12] Hershberger KA et al. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017 Apr;13(4):213-225. View Full Paper
[13] Gross CJ et al. Digestion and absorption of NAD by the small intestine of the rat J Nutr. 1983 Feb;113(2):412-20. View Abstract
[14] Poljsak B. NAMPT-Mediated NAD biosynthesis as the internal timing mechanism: in NAD+ World, time Is running in its own way. Rejuvenation Res. 2018 Jun;21(3):210-224 View Abstract
[15] Tsubota, K. The first human clinical study for NMN has started in Japan. NPJ Aging Mech. Dis. 2016, 2, 16021 View Abstract
[16] Strait, JE. Scientists identify new fuel-delivery route for cells. Washington University School of Medicine. Available at: https://medicine.wustl.edu/news/scientists-identify-new-fuel-delivery-route-for-cells/ Accessed: 9-14-2019
[17] Mills KF et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016: 24, 795–806. View Full Paper
[18] Anti-Aging compound in human clinical trial: will boosting NMN slow aging? Available at: https://hecmedia.org/posts/anti-aging-compound-in-human-clinical-trial-will-boosting-nmn-slow-aging-6/ Accessed 9-1-2019
[19] Guan Y et al. Nicotinamide Mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1-dependent manner. J Am Soc Nephrol. 2017 Aug;28(8):2337-2352. View Full Paper
[20] Martin As et al. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model.JCI Insight. 2017 Jul 20;2(14). View Full Paper
[21] Johnson S et al. NAD + biosynthesis, aging, and disease. F1000Res. 2018 Feb 1;7:132 View Full Paper
[22] Mills KF et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016; 24:795–806 View Full Paper
[23] Das A et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20 View Abstract
[24] Kathirvel E et al. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1068-77 View Full Paper
[25] Schmeisser K et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 2013;9(11):693–700. View Full Paper
[26] Bonkowski MS et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 November ; 17(11): 679–690 View Full Paper
[27] Kane AE et al. Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular disease. Circ Res. 2018 Sep 14;123(7):868-885. View Full Paper
[28] Sun WP et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. Clin Nutr, 2017. 36(4): p. 1136-1142 View Abstract
[29] Van der Meel R et al. Extracellular vesicles as drug delivery systems: lessons from the liposome field. J Control Release. 2014 Dec 10;195:72-85 View Abstract
[30] Yoshida M. Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice. Cell Metab. 2019 Aug 6;30(2):329-342.e5 View Abstract
[31] Yoshino J et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528 View Full Paper
[32] Gaddipati R et al. Visceral adipose tissue visfatin in nonalcoholic fatty liver disease. Ann Hepatol. 2010;9(3):266–70. View Abstract
[33] Revollo JR et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6(5):363–75 View Full Paper
[34] Caton PW et al. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated
[35] impairment of mouse islet function. Diabetologia. 2011;54(12):3083–92. View Abstract
[36] De Picciotto NE et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell 2016, 15, 522–530. View Full Paper
[37] Yoshino J et al. Nicotinamide mononucleotide, a key NAD (+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528–36 View Full Paper
[38] Uddin GM et al. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front. Pharmacol. 2016, 7, 258 View Full Paper
[39] Wei CC et al. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Sci. Rep. 2017, 7, 717 View Full Paper
[40] Wang X et al. Nicotinamide mononucleotide protects against –amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016, 1643, 1–9. View abstract
[41] Yao Z et al. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci. Lett. 2017, 647, 133–140. View Abstract
[42] Hou Y et al. NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc. Natl. Acad. Sci. USA 2018, 115, E1876–E1885 View Abstract
[43] Wei CC et al. NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia. Br J Pharmacol. 2017 Nov;174(21):3823-3836 View Full Paper
[44] Gomes AP et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013; 155, 1624–1638.View Full Paper
[45] Stromsdorfer KL et al. NAMPT-Mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice. Cell Rep. 2016 Aug 16;16(7):1851-60. View Abstract
[46] Camacho-Pereira J et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016; 23:1127–1139 View Full Paper
[47] Lin JB et al. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016; 17:69–85 View Full Paper
[48] Sheedfar F et al. Liver diseases and aging: friends or foes? Aging Cell. 2013 Dec;12(6):950-4 View Abstract
[49] Hamaguchi M. Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women.
[50] World J Gastroenterol. 2012 Jan 21;18(3):237-43 View Full Paper
[51] Day CR et al. Betaine chemistry, roles, and potential use in liver disease. Biochim Biophys Acta. 2016 Jun;1860(6):1098-106 View Abstract
[52] Zhao G et al. Betaine in inflammation: mechanistic aspects and applications. Front Immunol. 2018 May 24;9:1070. View Full Paper
[53] Ueland PM et al. Betaine: a key modulator of one-carbon metabolism and homocysteine status.
[54] Clin Chem Lab Med. 2005;43(10):1069-75. View Abstract
[55] Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. View Abstract
AMPK Charge+ References https://quicksilverscientific.com/ampkchargereferences
[1] Herzig S and Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018; 19(2): 121-135.
[2] Hardie DG, et al. Targeting an energy sensor to treat diabetes. Science. 2017; 357 (6350): 455-456.
[3] Foretz M and Viollet B. Activation of AMPK for a break in hepatic lipid accumulation and circulating cholesterol. EBio Medicine. 2018; 31: 15-16.
[4] Tamargo-Gomez I, et al. AMPK: Regulation of metabolic dynamics in the context of autophagy. Int J Mol Sci. 2018; 19(12): 3812.
[5] Furman D, et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019; 25: 1822-1832.
[6] Jeon SM, et al. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016; 48: e245.
[7] Shirwany NA and Zou MH. AMPK in cardiovascular health and disease. Acta Pharmacol Sin. 2010; 31(9): 1075-1084.
[8] Ruderman NB, et al. AMPK, insulin resistance, and the metabolic syndrome. J Clin Investig. 2013.
[9] Seabright AP, et al. AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner. FASEB J. 2020; 34(5): 6284-6301.
[10] Ruderman NB, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010; 298(4): E751-E760.
[11] Pan H and Finkel T. Key proteins and pathways that regulate lifespan. J Biol Chem. 2017; 292(16): 6452-6460.
[12] Connell NJ, et al. NAD+ metabolism as a target for metabolic health: have we found the silver bullet? Diabetologia. 2019; 62(6): 888-899.
[13] Anton SD, et al. Flipping the metabolic switch: Understanding and applying health benefits of fasting. Obesity (Silver Spring).
[14] Fan W and Evans RM. Exercise mimetics: Impact on health and performance. Cell Metab. 2017; 25(2): 242-247.
[15] Dolinksy VW, et al. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. J Physiol. 2012; 590(Pt 11): 2783-2799.
[16] Konrad M and Nieman DC. Evaluation of quercetin as a countermeasure to exercise-induced physiological stress. antioxidants in sports nutrition. 2015.
[17] Kaeberlein M, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005; 280(17): 17038-17045.
[18] Park D, et al. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. Sci Rep. 2016; 6: 21772.
[19] Grant R. Resveratrol increases intracellular NAD+ levels through the up-regulation of the NAD+ synthetic enzyme nicotinamide mononucleotide adenylyltransferase. Nature Precedings. 2010.
[20] Csiszar A, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol.
[21] Sun H, et al. Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell Death & Dis. 2018; 9: 824.
[22] Lee YS, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Pharmacol & Ther. 2006; 55(8).
[23] Gomes AP, et al. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta. 2012; 1822(2): 185-195.
[24] Rayamajhi N, et al. Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 Cells. Oxid Med Cell Longev. 2013; 2013: 154279.
[25] Li Y, et al. Quercetin, inflammation and immunity. Nutrients. 2016; 8(3): 167.
[26] Kim SG, et al. Quercetin-induced AMP-activated protein kinase activation attenuates vasoconstriction through LKB1-AMPK signaling pathway. J Med Food. 2018; 21(2): 146-153.
[27] Lewinska A, et al. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. Redox Biol. 2020; 28: 101337.
[28] Van Deursen JM. Senolytic therapies for healthy longevity. Science. 2019; 364(6441): 636-637.
[29] Weng Z, et al. Quercetin Is more effective than Cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012; 7(3): e33805.
[30] Jiang K, et al. Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells. Oncol Rep. 2015; 33(6): 2711-2718.
[31] Lovelace ES, et al. Silymarin suppresses cellular inflammation by inducing reparative stress signaling. J Nat Prod. 2015; 78(8): 1990-2000.
[32] Ye Y, et al. 3,3′-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy. Biochem Pharmacol. 2016; 115: 77-84.
[33] Hornero RA, et al. The impact of dietary components on regulatory T cells and disease. Front Immunol. 2020; 11: 253.
[34] Shen Y, Honma N et al. Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMPactivated protein kinase signaling. PLoS One. 2014 Feb 14;9(2):e8789
[35] Park KR, Nam D. β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Lett. 2011 Dec 22;312(2):178-88
[36] Mollazadeh H and Hosseinzadeh H. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iran J Basic Med Sci. 2016; 19(12): 1258-1270.
QuintEssential® 3.3 References https://www.quicksilverscientific.com/hypertonicreferences/
[1] Holm NG, Anderson EM. Abiotic synthesis of organic compounds under the conditions of submarine hydrothermal systems: a perspective. Planet Space Sci 1995; 43(1-2): 153-9.
[2] He HZ, Li HB et al. Determination of vitamin B1 in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 2005; 383(5): 875-9.
[3] Litchfield CD, Hood DW. Microbiological assay for organic compounds in seawater. II. Distribution of adenine, uracil, and threonine. Appl Microbiol 1966; 14(2): 145-51
[4] Quinton, R. L’eau De Mer, Milieu Organique: Constance Du Milieu Marin Originel, Comme Milieu Vital Des Cellules, À Travers La Série Animale. Ulan Press. 2012
[5] Yoshizawa Y, Tanojo H et al. Sea water or its components alter experimental irritant dermatitis in man, Skin Res. Technol., 2001 (7): 36–39.
[6] Kimata H, Tai H et al. Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS), Acta Med. (Hradec Kralove, Czech Repub.), 2002 (45): 2; 83–84.
[7] Tabary O, Muselet C et al. Reduction of chemokine IL8 and RANTES expression in human bronchial epithelial cells by a sea water derived saline through inhibited nuclear factor kB activation, Biochem. Biophys. Res.Commun., 2003 (309); 2: 310–316.
[8] Miyamura M, Yoshioka S et al. Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis, Biol. Pharm. Bull., 2004; (27): 11; 1784–1787.
[9] Slapak I, Skoupá J et al Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children, Arch. Otolaryn gol. Head Neck Surg., 2008 (134); 1: 67–74.
[10] Yoshioka S, Hamada A et al. Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 2003 Nov;26(11):1552-9.
[11] Armstrong LE, Ganio MS. Mild dehydration affects mood in healthy young women. J Nutr. 2012 Feb;142(2):382-8.
[12] Fadda R, Rapinett G. Effects of drinking supplementary water at school on cognitive performance in children. Appetite. 2012 Dec;59(3):730-7.
[13] Suhr JA, Hall J. The relation of hydration status to cognitive performance in healthy older adults. Int J Psychophysiol. 2004 Jul;53(2):121-5.
[14] Lieberman HR. Hydration and cognition: a critical review and recommendations for future research. J Am Coll Nutr. 2007;26(5S)
[15] Paik IY, Jeong MH et al. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7.
[16] Texas Heart Institute: Trace Elements: what they do and where to get them. Available at: https://www.texasheart.org/. Accessed June 1, 2019.
[17] Scotney B, Reid S. Body weight, serum sodium levels and renal function in an ultra-distance mountain run. Clin J Sport Med. 2015 Jul;25(4):341-6.
[18] Hoffman MD, Joslin J et al. Management of suspected fluid balance issues in participants of wilderness endurance events. Curr Sports Med Rep. 2017 Mar/Apr;16(2):98-102.
[19] Armstrong LE, Johnson EC et al. COUNTERVIEW: Is drinking to thirst adequate to appropriately maintain hydration status during prolonged endurance exercise? No. Wilderness Environ Med. 2016 Jun;27(2):195-8.
[20] Angier, N. The wonders of blood. Available at: https://www.nytimes.com/2008/10/21/science/21angi.html. Accessed June 1, 2019.
[21] Theocharis AD, Skandalis SS et al. Extracellular matrix structure. Adv Drug Deliv Rev. 2016 Feb 1;97:4-27.
[22] Pischinger, A. The Extracellular Matrix and Ground Regulation: Basis for a Holistic Biological Medicine. North Atlantic Books; 2007.
[23] Nabaa A, Clauser KR et al. The extracellular matrix: tools and insights for the “omics” era. Matrix Biol. (2016) 49; 10–24
[24] Gomez C, Deravi L. Self-assembling extracellular matrix proteins as materials for the condensation of silica nanostructures. RSC Advances 2016 (97) ra/c6ra20911d
[25] Silkin VA, Pautova LA et al. Drivers of phytoplankton blooms in the northeastern Black Sea. Mar Pollut Bull. 2019 Jan;138:274-28
[26] Litchman E, Klausmeier CA et al. The role of phytoplankton functional traits in structuring phytoplankton communities: scaling from cellular to ecosystem level. Ecol. Lett. 2007(10); 1170–1181
[27] Winder M, Cloern JE. The annual cycles of phytoplankton biomass. Phil. Trans. R. Soc. 2010; B 365: 3215–3226
[28] Lemke KH, Rosenbauer RJ et al. Peptide synthesis in early Earth hydrothermal systems. Astrobiology 2009; 9(2):141-6.
[29] Khokhlov AN, Morgunova GV et al. Pilot study of a potential geroprotector, “Quinton Marine Plasma”, in experiments on cultured cells. Biological Sciences Bulletin, 2015; (70):1; 7–11.
[30] Alberola J, Coll F. Marine therapy and its healing properties, Curr. Aging Sci., 2013; (6): 1; 63–75.
[31] Campos, M. Heart rate variability: A new way to track well-being. Harvard Health Publishing, Harvard Medical School. Available at: https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789. Accessed June 1, 2019.
[32] Presentation by Michael Kesller, DC. Quinton and the Extracellular Matrix. Available at: https://www.youtube.com/watch?v=XYFbuTQSjNo Accessed June 1, 2019.
[33] Ortells, JMS. Study of the Immunomodulatory Activity of QT solution in human PBMNc. Abstracts. 2nd European Congress of Immunology; European Journal of Immunology, Supp. 1/09
[34] Radhakrishnan G, Yamamoto M. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression. Biochem Biophys Res Commun. 2009 Sep 11;387(1):25-30.
[35] Dittman R. Bio-Terrain, evolutionary biology, and the practice of medicine in the early 1900’s: an intro to René Quinton’s marine plasma. Explore. 2006: (15):4
[36] Szent-Györgyi, A. Biology and pathology of water. Perspectives in Biology and Medicine. 1971 (14);2 : 239-24f9.
Methyl Charge+ References https://www.quicksilverscientific.com/methylchargereferences/
[1] McKee SE et al. Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition: considerations for future research Nutrition Reviews, 2018 (75): 7:497-511 View Full Paper
[2] Williams AC et al. Nicotinamide, NAD(P)(H), and methyl-group homeostasis evolved and became a determinant of aging diseases: hypotheses and lessons from Pellagra. Curr Gerontol Geriatr Res. 2012;2012:302875. View Full Paper
[3] Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. View Abstract
[4] Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916 View Abstract
[5] Hershberger KA et al. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017 Apr;13(4):213-225. View Full Paper
[6] Tasselli L et el. Methylation gets into rhythm with NAD(+)-SIRT1Nat Struct Mol Biol. 2015 Apr;22(4):275-76 View Abstract
[7] Aguilar-Arnal L et al. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.Nat Struct Mol Biol. 2015 Apr;22(4):312-8. View Full Paper
[8] Cantó C et al. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 2015 Jul 7;22(1):31-53. View Full Paper
[9] Kang-Lee YA et al. Metabolic effects of nicotinamide administration in rats. J Nutr. 1983 Feb;113(2):215-21. View Abstract
[10] Aksoy S et al. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 1994 269, 14835–14840.
[11] Li W et al. NAD+ content and its role in mitochondria. Mitochondrial Regulation. 2014: 39–48 View Abstract
[12] Lee CF et al. Targeting NAD+ metabolism as interventions for mitochondrial disease. Sci Rep. 2019 Feb 28;9(1):3073. View Abstract
[13] Pelizzola M. The DNA methylome. FEBS Lett. 2011 Jul 7; 585(13): 1994–2000. View Full Paper
[14] Moore LD et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38.View Full Paper
[15] Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol. 2008;15(2):72–75. View Full Paper
[16] Friso S et al. One-carbon metabolism and epigenetics. Mol Aspects Med. 2017 Apr;54:28-36. View Abstract
[17] Shames DS, Minna JD et al. DNA methylation in health, disease, and cancer. Curr Mol Med 7: 85-102View Full Paper
[18] gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicol Sci. 2019 May 14. pii: kfz110 View Full Paper
[19] Ligthart S et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255 View Full Paper
[20] NIH U.S. National Library of Medicine, MTHFR gene. Genetics Home Reference Available at: https://ghr.nlm.nih.gov/gene/MTHFR Accessed 1-4-2020
[21] Castro R et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. Journal of Medical Genetics 2004;41:454-458View Full Paper
[22] Hustad S et al. Riboflavin and methylenetetrahydrofolate reductase. Madame Curie Bioscience Database [Internet]. View Full Paper
[23] Pinto JT et al. Riboflavin. Advances in Nutrition 2016 (5):5;973-975 View Full Paper
[24] O’Leary F. Vitamin B12 in health and disease Nutrients. 2010 Mar;2(3):299-316. View Full Paper
[25] James JS, Melnyk S et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1): 425–430 View Full Paper
[26] Belardo A et al. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children J Nutr Biochem. 2019 Aug;70:38-46. View Abstract
[27] Anderson OS e al. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation.J Nutr Biochem. 2012 Aug;23(8):853-9. View Full Paper
[28] Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35View Full Paper
[29] Chang CY et al. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41View Abstract
[30] Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93View Full Paper
[31] Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36View Full Paper
[32] Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811View Full Paper
H2 Elite References https://www.quicksilverscientific.com/h2elitereferences/
[1]Ohsawa I, Ishikawa M et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007 Jun;13(6):688-94
[2] Sauer H, Wartenberg M et al. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 2001 11, 173–186
[3] Liu H, Colavitti R et al. Redox-dependent transcriptional regulation. Circ. Res. 2005 97, 967–975
[4] Bjelakovic G. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013 Sep 6;8(9):e74558
[5] Apostolova N, Victor VM. Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal. 2015 Mar 10;22(8):686-729
[6] Ohta, S. A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease. Curr. Med. Chem. 2003 10, 2485–2494
[7] Turrens JF. Mitochondrial formation of reactive oxygen species. J. Physiol. (Lond.) 2003 552, 335–344
[8] Zhai X, Chen X et al. Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression Free Radic Biol Med. 2013 Dec;65:731-741
[9] Yu J, Zhang W. Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression Toxicol Lett. 2015 Nov 4;238(3):11-9
[10] Hara F, Tatebe J et al. Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.Circ J. 2016 Aug 25;80(9):2037-46
[11] Qiang Ma. Role of Nrf2 in oxidative stress and toxicit. Annu Rev Pharmacol Toxicol. 2013; 53: 401–426.
[12] Itoh T, FujitaY et al. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651–6
[13] Itoh T, Hamada N et al. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun. 2011;411(1):143–9
[14] Hayashida K, Sano M et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008;373(1):30–5
[15] Zhang Y, Sun Q et al. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol. 2011;148(1):91–5
[16] Zhang G, Gao S et al. Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats. Sci Rep. 2015;5:9858
[17] Shinbo T, Kokubo K et al. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Physiol Heart Circ Physiol. 2013;305(4):H542–50.
[18] Wood KC, Gladwin MT. The hydrogen highway to reperfusion therapy. Nat Med 2007 (13):6 673-674
[19] Ito M, Hirayama M et al. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamineinduced Parkinson’s disease in rats. Med Gas Res. 2012;2(1):15
[20] Zhang CB, Tang YC et al. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-kappaB signaling pathway. Exp Ther Med. 2015;9(6):2114–20
[21] Fukuda K, Asoh S et al. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun.2007;361(3):670–4.
[22] Shin MH, Park R et al. Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. PLoS One. 2013;8(4):e61696
[23] Yoon KS, Huang XZ et al. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biol Pharm Bull. 2011;34(11):1671–7.
[24] Ishibashi T, Sato B et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27
[25] Chen Q, Chen P et al. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013;40(6):857–63
[26] Xin T, Fang S. The role of hydrogen in Alzheimer’s disease. Med Gas Res. 2018 Oct-Dec; 8(4): 176–180
[27] Ichihara M, Sobue S et al., Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles. Med Gas Res, 2015. 5: 12
[28] Song G, Li M et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013 54(7), 1884–1893.
[29] Da Ponte A, Giovanelli N et al. Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness. 2018 May;58(5):612-621
[30] LeBaron TW, et al. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Can J Physiol Pharmacol. 2019; 97(9). [online].
Ultra Binder® References https://www.quicksilverscientific.com/ultrabinderreferences/
[1] Frolis VV, Nikolav VG et al. Effect of enteroabsorption on animal lifespan. Biomat. Art. 1989. 17(3): 341-351.
[2] Su W, Ding X. Methods of endotoxin detection. J Lab Autom. 2015 Aug;20(4):354-64
[3] Aitken AE, Richardson TA et al. Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol 2006: 46:123–149
[4] Bolder U, Ton-Nu HT et al. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997: 112:214–225.
[5] Cherrington NJ, Slitt AL et al. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug MetabDispos2004: 32:734–741
[6] Tang W, Yi C et al. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats. 2000 Mol Cell Biol Res Commun 4:90–97
[7] Maklad A, Emara A et al. Pediatric poisoning in Egypt. Journal of Applied Pharmaceutical Science, 2012 2 (2): 1-6.
[8] Khalid J, Zailaey A. Medical and environmental applications of activated charcoal: review article. European Scientific Journal January 2015 (11): 3: 50-56
[9] Neuvonen J, Olkkola KT. Oral activated charcoal in the treatment of intoxications: role of single and repeated doses. Med Toxicol, 1988: 3; 33-58
[10] Karnib M, Kabbani A et al. Heavy metals removal using activated carbon, silica and silica activated carbon composite. Energy Procedia 2014: 50, 113 – 120.
[11] Du XN, Niu Z et al. Effect of activated charcoal on endotoxin adsorption. Part I. An in vitro study. Biomater Artif Cells Artif Organs. 1987;15(1):229-35
[12] Dalefield R. Emergency care and stabilization of the poisoned patient. In: Veterinary Toxicology for Australia and New Zealand, 2017: 19-32
[13] Rodriguez-Reinoso. Activated carbon and adsorption. in Encyclopedia of Materials: Science and Technology, 2001: 22-24
[14] Krasopoulos JC, De Bari VA et al The adsorption of bile salts on lipids. 1980 May;15(5):365-70
[15] Neuvonen PJ, Kuusisto P. Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationships and comparison with cholestyramine Eur J Clin Pharmacol. 1989;37(3):225-30
[16] Musso CG, Michelangelo H et al. Combination of oral activated charcoal plus low protein diet as a new alternative for handling in the old end-stage renal disease patients Saudi J Kidney Dis Transpl. 2010 Jan;21(1):102-4
[17] Koide, S. S. Chitin-chitosan: properties, benefits and risks. Nutrition Research 1998;8(6):1091-1101
[18] Macchi G. A new approach to the treatment of obesity: chitosan’s effects on body weight reduction and plasma cholesterol levels. Acta Toxicol Ther 1996;17:303-320
[19] Lütjohann D, Marinova M. Nutrients. Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects. 2018 Jan 11;10(1)
[20] Maezaki Y, Tsuji K et al. Hypocholesterolaemic effect of chitosan in adult males. Biosc Biochem Biotech 1993;57:1439-1444
[21] Shoemaker, RC. (2001) Desperation Medicine. Gateway Press: Baltimore. 2. Shoemaker, RC, Schaller J, Schmidt P. (2005) Mold Warriors: Fighting America’s Hidden Threat. Gateway Press: Baltimore
[22] Karunasena E, Larrañaga MD et al. Building-Associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment. Mycopathologia. 2010 Dec;170(6):377-90
[23] Carretero MI. Clay minerals and their beneficial effects upon human health. A review. Appl Clay Sci 2002; 21: 155–63.
[24] Herrera P, Burghardt RC et al. Adsorption of Salmonella enteritidis by cetylpyridinium-exchanged montmorillonite clays. Vet Microbiol 2000; 74: 259–72
[25] Haydel SE, Remenih CM. J Broad-spectrum in vitro antibacterial activities of clay minerals against antibiotic-susceptible and antibiotic-resistant bacterial pathogens Antimicrob Chemother. 2008 Feb;61(2):353-61
[26] Schaumberger S, Ladining A et al. Evaluation of the endotoxin binding efficiency of clay minerals using the Limulus Amebocyte lysate test: an in vitro study. MB Express. 2014; 4: 1
[27] Bland, Jeffrey. Effect of orally consumed Aloe vera Juice on Gastrointestinal Function in Normal Humans. Preventative Medicine, March-April 1985
[28] Marzorati M. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol. 2010 May 15;139(3):168-76.
[29] Im SA, Lee YR et al. In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel. Arch Pharm Res. 2010 Mar;33(3):451-6.
[30] Visuthikosol V, Chowchuen B et al. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai. 1995 Aug;78(8):403-9
[31] Im SA, Oh ST et al. Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. International Immunopharmacology. 2005;5(2):271-279
[32] Hu Y, Xu J, Hu Q. Evaluation of antioxidant potential of aloe vera (Aloe barbadensis miller) extracts. J Agric Food Chem. 2003 Dec 17;51(26):7788-91
[33] Eshun, K., He, Q. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries—a review. Crit. Rev. Food Sci. Nutr. 2004: 44, 91–96
[34] Mohamed RE, Gadour MO. The lowering effect of Gum Arabic on hyperlipidemia in Sudanese patients. Front Physiol. 2015 May 18;6:160
[35] Crociani F, Alessandrini A et al. Degradation of complex carbohydrates by Bifidobacterium spp. Int.J Food Microbiol. 1994;24:199-210.
[36] Walter DJ, Eastwood MA et al. Fermentation of wheat bran and gum arabic in rats fed on an elemental diet. Br.J.Nutr. 1988;60:225-32
[37] Wyatt GM, Bayliss CE et al. A change in human faecal flora in response to inclusion of gum arabic in the diet. Br.J.Nutr. 1986;55:261-6.