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Bio-Age Reset References

Dr. Shade’s Liver Sauce®  https://www.quicksilverscientific.com/liversaucereferences/

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[44] Saw CL, Cintrón M, et al. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates Biopharm Drug Dispos. 2011 Jul;32(5):289-300. Biopharm Drug Dispos. 2011 Jul;32(5):289-300

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[50] Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016 Nov 23;20:36

[51] Alyautdin R, Khlain I et al. Nanoscale drug delivery systems and the blood brain barrier.  Int J Nanomedicine. 2014 Feb 7;9:795-81

Ultra Binder® Stick Packs Universal Toxin Binder https://www.quicksilverscientific.com/ultrabinderreferences/

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[2] Su W, Ding X. Methods of endotoxin detection. J Lab Autom. 2015 Aug;20(4):354-64

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[4] Bolder U, Ton-Nu HT et al. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 1997: 112:214–225.

[5] Cherrington NJ, Slitt AL et al. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug MetabDispos2004: 32:734–741

[6] Tang W, Yi C et al. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats. 2000 Mol Cell Biol Res Commun 4:90–97

[7] Maklad A, Emara A et al. Pediatric poisoning in Egypt. Journal of Applied Pharmaceutical Science, 2012 2 (2): 1-6.

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[10] Karnib M, Kabbani A et al. Heavy metals removal using activated carbon, silica and silica activated carbon composite. Energy Procedia 2014: 50, 113 – 120.

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[16] Musso CG, Michelangelo H et al. Combination of oral activated charcoal plus low protein diet as a new alternative for handling in the old end-stage renal disease patients Saudi J Kidney Dis Transpl. 2010 Jan;21(1):102-4

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[19] Lütjohann D, Marinova M. Nutrients. Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects. 2018 Jan 11;10(1)

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[21] Shoemaker, RC. (2001) Desperation Medicine. Gateway Press: Baltimore. 2. Shoemaker, RC, Schaller J, Schmidt P. (2005) Mold Warriors: Fighting America’s Hidden Threat. Gateway Press: Baltimore

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Glutathione Complex  https://www.quicksilverscientific.com/glutathionecomplexreferences/

[1] Homma T et al. Application of glutathione as anti-oxidative and anti-aging drugs. Curr Drug Metab. 2015;16(7):560-71 View Abstract

[2] Balendiran GK et al. Cell Biochem Funct. The role of glutathione in cancer. 2004 Nov-Dec;22(6):343-52. View Abstract

[3] Mari M et al. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009 Nov;11(11):2685-70 View Full Paper

[4] Perricone C et al. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. View Abstract

[5] Dröge W et al. Glutathione and immune function. Proc Nutr Soc. 2000 Nov;59(4):595-600. Review. View Abstract

[6] Bajic VP et al. Glutathione “redox homeostasis” and its relation to cardiovascular disease. Oxidative Medicine and Cellular Longevity 2019 View Abstract

[7] Abenavoli L. et al. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010 Oct;24(10):1423-32 View Abstract

[8] Day CR et al. Betaine chemistry, roles, and potential use in liver disease. Biochim Biophys Acta. 2016 Jun;1860(6):1098-106. View Abstract

[9] Khodayar MJ et al. Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability. Biomed Pharmacother. 2018 Jul;103:1436-1445 View Abstract

[10] Pizzorno J. Glutathione! Integrative Medicine 2014 (13):1:8-12 View Full Paper

[11] Forman HJ. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. View Abstract

[12] Hodges RE et al. Modulation of metabolic detoxification pathways using foods and food-derived components: a scientific review with clinical application. J Nutr Metab. 2015;2015:760689 View Full Paper

[13] Keum YS. Regulation of Nrf2-mediated phase II detoxification and anti-oxidant genes. Biomol Ther. 2012;20(2):144-151. View Abstract

[14] Fraternale A et al. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275 View Abstract

[15] Kamide Y. Allergy. Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization. Allergy. 2011 Sep;66(9):1183-92. View Abstract

[16] Dröge W et al. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J 1994;8:1131–8. View Abstract

[17] Gambhir JK et al. Correlation between blood antioxidant levels and lipid peroxidation in rheumatoid arthritis. Clin Biochem 1997;30:351–5. View Abstract

[18] Ortona E, Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev 2008;7:579–84. View Abstract

[19] Griffiths HR. Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmun Rev 2008;7:544–9. View Abstract

[20] Burek CL, Rose NR. Autoimmune thyroiditis and ROS. Autoimmun Rev 2008;7:530–7. View Abstract

[21] Gheita TA et al.  Measurement of malondialdehyde, glutathione, and glutathione peroxidase in SLE patients. Methods Mol Biol. 2014;1134:193-9 View Abstract

[22] Kumar D et al. A link between maternal malnutrition and depletion of glutathione in the developing lens: a possible explanation for idiopathic childhood cataract? Clin Exp Optom. 2013 Nov;96(6):523-8 View Abstract

[23] Teskey G. Glutathione as a marker for human disease. Adv Clin Chem. 2018;87:141-159. View Abstract

[24] Jiang S et al. Glutathione protects against hepatic injury in a murine model of primary Sjögren’s syndrome. Bosn J Basic Med Sci. 2016 Aug 2;16(3):227-31 View Abstract

[25] Sinha R et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018 Jan;72(1):105-111 View Abstract

[26] Drisko JA. Chelation Therapy. In: Integrative Medicine (Fourth Edition) 2018: (107): 1004-1014.

[27] Lawley SD et al. Mathematical modeling of the effects of glutathione on arsenic methylation. Theor Biol Med Model. 2014 May 16;11:20. View Abstract

[28] Guildford FT et al. Deficient glutathione in the pathophysiology of mycotoxin-related illness. Toxins (Basel). 2014 Feb 10;6(2):608-23 View Full Paper

[29] Hope JH et al. A review of the diagnosis and treatment of ochratoxin a inhalational exposure associated with human illness and kidney disease including focal segmental glomerulosclerosis. J. Environ. Public Health 2012: 2012, 835059. View Abstract

[30] Damy T et al. Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities. PLoS One 2009. (4):3: e4781 vol. 4. View Abstract

[31] Biswas SK et al. Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E−/− Biochemical and Biophysical Research Communications 2005 (338): 3: 1368–1373 View Abstract

[32] Shimizu H et al. Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study.  Stroke. 2004 (35):9: 2072-2077 View Abstract

[33] de la Asuncion JG et al. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. The FASEB Journal. 1996;10(2):333–338. View Abstract

[34] Rae CD et al. Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy. Anal Biochem. 2017 Jul 15;529:127-143. View Abstract

[35] Saharan S et al. The emerging role of glutathione in Alzheimer’s disease J Alzheimers Dis. 2014;40(3):519-29. View Abstract

[36] Chen Y et al. Glutathione defense mechanism in liver injury: insights from animal models. Food Chem Toxicol. 2013 Oct;60:38-44 View Full Paper

[37] Crocenzi FA  et al. Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. Curr Med Chem. 2006;13(9):1055-74. View Abstract

[38] Soto C. Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus Phytomedicine. 2010 Dec 1;17(14):1090-4. View Abstract

[39] Kiruthiga PV Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes–an in vitro study. Toxicol Appl Pharmacol. 2010 Sep 1;247(2):116-28. View Abstract

[40] Day CR et al. Betaine chemistry, roles, and potential use in liver disease. Biochim Biophys Acta. 2016 Jun;1860(6):1098-106 View Abstract

[41] Kempson SA et al. Betaine transport in kidney and liver: use of betaine in liver injury. Cell Physiol Biochem. 2013;32(7):32-40 View Abstract

[42] Zhao G et al. Betaine in inflammation: mechanistic aspects and applications.  Front Immunol. 2018 May 24;9:1070. View Full Paper

[43] Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. View Abstract

[44] Mikkelsen K et al. B Vitamins and Ageing. In: Biochemistry and Cell Biology of Ageing: Part I Biomedical Science, Subcellular Biochemistry 90: Chapter 15. View Abstract

[45] Hodges RE et al. Modulation of metabolic detoxification pathways using foods and food-derived components: a scientific review with clinical application. J Nutr Metab. 2015;2015:760689. View Abstract

[46] Gambhir JK et al. Correlation between blood antioxidant levels and lipid peroxidation in rheumatoid arthritis. Clin Biochem 1997;30:351–5. View Abstract

[47] Ortona E, Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev 2008;7:579–84. View Abstract

[48] Griffiths HR. Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmun Rev 2008;7:544–9. View Abstract

[49] Burek CL, Rose NR. Autoimmune thyroiditis and ROS. Autoimmun Rev 2008;7:530–7. View Abstract

[50] Gheita TA et al.  Measurement of malondialdehyde, glutathione, and glutathione peroxidase in SLE patients. Methods Mol Biol. 2014;1134:193-9 View Abstract

[51] Kumar D et al. A link between maternal malnutrition and depletion of glutathione in the developing lens: a possible explanation for idiopathic childhood cataract? Clin Exp Optom. 2013 Nov;96(6):523-8 View Abstract

[52] Teskey G. Gluathione as a marker for human disease. Adv Clin Chem. 2018;87:141-159. View Abstract

[53] Jiang S et al. Glutathione protects against hepatic injury in a murine model of primary Sjögren’s syndrome. Bosn J Basic Med Sci. 2016 Aug 2;16(3):227-31 View Abstract

Cat’s Claw Elite® https://www.quicksilverscientific.com/catsclawelitereferences/

[1] Cat’s Claw. American Botanical Councilhttp://cms.herbalgram.org/ABCGuide/Monographs/CatsClaw.html?ts=1574449798&signature=699be2950b6b1525d87c4cc1e64b16a3.

[2] Navarro M, et al. Polyphenolic composition and antioxidant activity of Uncaria tomentosacommercial bark products. Antioxidants (Basel). 2019; 8(9): pii: E339.

[3] Aguilar JLH, et al. Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). J Ethnopharmacol. 2002; 81(2): 271-276.

[4] Herrera DR, et al. Antimicrobial activity and substantivity of Uncaria tomentosain infected root canal dentin. Braz Oral Res. 2016; 30(1): e61.

[5] Farias I, et al. Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells. J Ethnopharmacol. 2011; 137(1): 856-863.

[6] Hardin SR. Cat’s Claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract. 2007; 13(1): 25-28.

[7] Mur E, et al. Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol. 2002; 29(4): 678-681.

[8] Schlievert PM, et al. Glycerol monolaurate contributes to the antimicrobial and anti-inflammatory activity of human milk. Sci Rep. 2019; 9: 14550.

[9] Da Silva Lima R, Block JM. Coconut oil: what do we really know about it so far? Food Qual Safety. 2019; 3(2): 61-72.

[10] Saleem D, et al. In vitro evaluation of antifungal activity of monolaurin against Candida albicans biofilms. Peer J. 2016; 4: e2148.

[11] Ham Y, Kim TJ. Inhibitory activity of monoacylglycerols on biofilm formation in Aeromonas hydrophilaStreptococcus mutansXanthomonas oryzae, and Yersinia enterocoliticaSpringerplus. 2016; 5(1): 1526.

[12] Chirumbolo S, et al. The role of vitamin D in the immune system as a pro-survival molecule. Clin Ther. 2017; 39(5): 894-916.

[13] Prietl B, et al. Vitamin D and immune function. Nutrients. 2013; 5(7): 2502-2521.

[14] Heaney RP, et al. Vitamin D3 is more potent than vitamin D2 in humans. JCEM. 2011; 96(3): E447-E452.

[15] Firenzuoli F, et al. Essential oils: New perspectives in human health and wellness. Evid Based Complement Alternat Med. 2014; 2014: 467363.

[16] Hussain AI, et al. Chemical composition, and antioxidant and antimicrobial activities of essential oil of spearmint (Mentha spicata L.) from Pakistan. J Essent Oil Res. 2010; 22(1): 78-84.

[17] Nayebi N, et al. A systematic review of the efficacy and safety of Rosa damascena Mill. with an overview on its phytopharmacological properties. Complement Ther Med. 2017; 34: 129-140.

[18] Miraj S, et al. Melissa officinalis L: A review study with an antioxidant perspective. J Evid Based Complementary Altern Med. 2017; 22(3): 385-394.

[19] Sherry M, et al. Essential oils encapsulated in liposomes: a review. J Liposome Res. 2013; 23(4): 268-275.

[20] Jackman JA, et al. Nanotechnology formulations for antibacterial free fatty acids and monoglycerides. Molecules. 2016; 21(3): 305.

[21] Mohammadi M, et al. Formulation of nanoliposomal vitamin D3 for potential application in beverage fortification. Adv Pharm Bull. 2014; 4(Suppl 2): 569-575.

[22] Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016; 20: 36.

[23] Alyautdin R, et al. Nanoscale drug delivery systems and the blood-brain barrier. Int J Nanomedicine. 2014; 9: 795-811.

[24] Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9): 1015-1035.

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