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Biohacker Bundle References


NAD + Platinum  https://www.quicksilverscientific.com/nadplatinumreferences/

[1] Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. 

[2] Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916

[3] Keller K and Engelhardt M. Strength and muscle mass loss with the aging process. Age and strength loss. Muscles Ligaments Tendons J. 2013; 3(4): 346-350.

[4] Chang AM and Halter JB. Aging and insulin secretion. Am J Physiol Endocrinol Metab. 2003; 284(1): E7-12.

[5] Caito SW and Aschner M. NAD+ Supplementation attenuates methylmercury dopaminergic and mitochondrial toxicity in Caenorhabditis Elegans. Toxicol Sci. 2016; 151(1): 139-149.

[6] Gizem Kivrak E, et al. Effects of electromagnetic fields exposure on the antioxidant defense system. J Microsc Ultrastruct. 2017; 2017; 5(4): 167-176.

[7] Xie N, et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020; 5: 227.

[8] Hong W, et al. Nicotinamide mononucleotide: A promising molecule for therapy of diverse diseases by targeting NAD+ metabolism. Front Cell Dev Biol. 2020.

[9] Wu, L et al. The elusive NMN transporter is found. Nat Metab 2019: 1; 8-9

[10] Yamaguchi S and Yoshino J. Adipose tissue NAD+ biology in obesity and insulin resistance: From mechanism to therapy. Bioessays. 2017; 39(5): 10.1002/bies.201600227.

[11] Guarente L, Franklin H. Epstein lecture: sirtuins, aging, and medicine. N Engl J Med. (2011) 364:2235–44.

[12] Kane AE, Sinclair DA. Sirtuins and NAD+ in the development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018; 123:868-885.

[13] Mangerich A, et al. Pleiotropic cellular functions of PARP1 in longevity and aging: Genome maintenance meets inflammation. Oxid Med Cell Longev. 2012; 2012: 321653.

[14] Bonkowski MS and Sinclair D. Slowing aging by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016; 17(11): 679-690.

[15] Lewinska A, et al. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. Redox Biol. 2020; 28: 101337.

[16] Jesko H, et al. Sirtuins and their roles in brain aging and neurodegenerative disorders. Neurochem Res. 2017; 42(3): 876-890.

[17] Warren JL, et al. Regulation of adaptive immune cells by sirtuins. Front Endocrinol (Lausanne). 2019; 10:466.

[18] Radak Z, et al. The systemic role of SIRT1 in exercise mediated adaptation. Redox Biol. 2020; 35: 101467.

[19] Vargas-Ortiz K, et al. Exercise and sirtuins: A way to mitochondrial health in skeletal muscle. Int J Mol Sci. 2019; 20(11): 2717.

[20] Asher G, et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2): 317-328.

[21] Grabowska W, et al. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017; 18(4): 447-476.

[22] Schafer MJ, et al. Exercise prevents diet-induced cellular senescence in adipose tissue. Diabetes. 2016; 65(6): 1606-1615.

[23] Han YM, et al. β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4.Mol Cell. 2018; 71(6): 1064-1078.

[24] Weng Z, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012; 7(3): e33805.

[25] Mohar DS and Malik S. The sirtuin system: The holy grail of resveratrol? J Clin Exp Cardiol. 2012; 3(11): 216.

[26] Hustad S, et al. Riboflavin and methylenetetrahydrofolate reductase. Madame Curie Bioscience Database. 2013.

[27] Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36 View Full Paper

[28] Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier.  Int J Nanomedicine. 2014 Feb 7;9:795-811 View Full Paper


Membrane Mend™  https://www.quicksilverscientific.com/membranemendreferences/

[1] Casares D, et al. Membrane lipid composition: Effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues. Int J Mol Sci. 2019; 20(9): 2167.

[2] Leekumjorn S, et al. The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. Biochim Biophys Acta. 2009; 1788(7): 1508-1516.

[3] Van Meer G, et al. Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol. 2009; 9(2): 112-124.

[4] Zorova LD, et al. Mitochondrial membrane potential. Anal Biochem. 2018; 552: 50-59.

[5] Chew S, et al. Impairment of mitochondrial function by particulate matter: Implications for the brain. Neurochem Int. 2020; 135(104694).

[6] Zulkifli-Cunningham Z, et al. Clinical effects of chemical exposures on mitochondrial function. Toxicology. 2017; 391: 90-99.

[7] Lin JH, et al. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol. 2008; 3: 399-425.

[8] Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010; 140(6): P900-P917.

[9] Kalghatgi S, et al. Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells. Sci Transl Med. 2013; 5(192): 192ra85.

[10] Santini SJ, et al. Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems. Oxid Med Cell Longev. 2018; 2018: 5076271.

[11] Zorova LD, et al. Mitochondrial membrane potential. Anal Biochem. 2018; 552: 50-59.

[12] Nicolson GL, et al. Clinical uses of membrane lipid replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer. Discoveries (Craiova). 2016; 4(1): e54.

[13] Na JY, et al. Hepatoprotective effect of phosphatidylcholine against carbon tetrachloride liver damage in mice. Biochem Biophys Res Commun. 2015; 460(2): 308-313.

[14] Maev IV, et al. Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study). BMJ Open Gastroenterol. 2020; 7: e000341.

[15] Kennelly JP, et al. Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis. J Lipid Res. 2018; 59(9): 1695-1708.

[16] Schneider H, et al. Lipid-based therapy for ulcerative colitis—Modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation. Int J Mol Sci. 2010; 11(10): 4149-4164.

[17] Chen M, et al. Oral phosphatidylcholine improves intestinal barrier function in drug-induced liver injury in rats. Gastroenterol Res Pract. 2019; Article ID 8723460.

[18] Lichtenberger LM. Role of phospholipids in protection of the GI mucosa. Digestive Dis Sci. 2013; 58: 891-893.

[19] Blusztajn JK, et al. Neuroprotective actions of dietary choline. Nutrients. 2017; 9(8): 815.

[20] Ojo JO, et al. Disruption in brain phospholipid content in a humanized tau transgenic model following repetitive mild traumatic brain injury. Front Neurosci. 2018; [online].

[21] Yu C, et al. HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells. J Cell Molec Med. 2019; 23(5): 3140-3150.

[22] Wen G, et al. Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes. PLoS One. 2017; [online].

[23] Lefort N, et al. Dietary Buglossoides Arvensisoil increases circulating n-3 polyunsaturated fatty acids in a dose-dependent manner and enhances lipopolysaccharide-stimulated whole blood interleukin-10—A randomized placebo-controlled trial. Nutrients. 2017; 9(3): 261.

[24] Lefort N, et al. Consumption of Buglossoides arvensis seed oil is safe and increases tissue long-chain n-3 fatty acid content more than flaxseed oil – results of a phase I randomised clinical trial. J Nutr Sci. 2016; 5: e2.

[25] Sztretye M, et al. Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging. Oxid Med Cell Longev. 2019; 2019: 3849692.


The One References https://www.quicksilverscientific.com/theonereferences/

[1] Ryan MT. Mitochondria – the energy powerhouses. Semin Cell Dev Biol. 2018 Apr;76:130-131. View Abstract

[2] Linnane AW et al. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 1989 Mar 25;1(8639):642-5 View Abstract

[3] Harris CB. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013 Dec;24(12):2076-84. View Full Paper

[4] Sharma A. Coenzyme Q10 and heart failure: a state of the art review. Circ Heart Fail. 2016 Apr;9(4):e002639. View Full Paper

[5] Vaquero EC et al. Tocotrienols: balancing the mitochondrial crosstalk between apoptosis and autophagy. Autophagy. 2007 Nov-Dec;3(6):652-4. View Abstract

[6] De Oliveira MR et al. Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view. Biochim Biophys Acta. 2016 Apr;1860(4):727-45. View Abstract

[7] Panossian A et al. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219 View Abstract

[8] Saihara K et al. Pyrroloquinoline Quinone, a redox-active o-Quinone, stimulates mitochondrial biogenesis by activating the SIRT1/PGC-1α signaling pathway. Biochemistry. 2017 Dec 19;56(50):6615-6625 View Abstract

[9] Pang KL et al. The role of tocotrienol in protecting against metabolic diseases. Molecules. 2019 Mar 6;24(5). View Full Paper

[10] Springer M et al. Resveratrol and its human metabolites-effects on metabolic health and obesity. Nutrients. 2019 Jan 11;11(1). pii: E143. View Full Paper

[11] Most J et al. Calorie restriction in humans: An update. Ageing Res Rev. 2017 Oct;39:36-45 View Full Paper

[12] National Institute of General Medical Sciences. Inside the Cell. Available at: https://www.nigms.nih.gov/education/Booklets/Inside-the-Cell/Pages/Home.aspx Accessed 10-17-2019

[13] Zhou Z et al. Mitochondrial metabolism in major neurological diseases. Cells. 2018 Nov 23;7(12). View Full Paper

[14] Dunn D et al. Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol. 2015 Dec;6:472-485. View Full Paper

[15] Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annu Rev Genet. 2005;39:359-407. View Full Paper

[16] Zhang Y, Xu H. Translational regulation of mitochondrial biogenesis. Biochem Soc Trans. 2016 Dec 15;44(6):1717-1724. View Abstract

[17] Meyer JN et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. View Full Paper

[18] Misra HS et al. Pyrroloquinoline-quinone and its versatile roles in biological processes. J Biosci 2012;37:313–25 View Abstract

[19] Chowanadisai W et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem 2010;285:142–52. View Full Paper

[20] Villegas R et al. Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.Ann Hum Genet. 2014 Jan;78(1):23-32 View Abstract

[21] Bauerly K et al. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One 2011;6:e21779 View Full Paper

[22] Rucker R et al. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009 Sep;14(3):268-77 View Abstract

[23] Stites T et al. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. J Nutr. 2006 Feb;136(2):390-6. View Abstract

[24] Wen H et al. Mini-review; functions and action mechanisms of PQQ in osteoporosis and neuro injury. Neurosci Lett. 2018 Nov 20;687:104-110 View Abstract

[25] Zhang Q, Ding M, Gao XR, Ding F. Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes. Genet Mol Res. 2012 Aug 16;11(3):2652-64. View Abstract

[26] Zhu BQ et al. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006 Jun;11(2):119-28 View Abstract

[27] Tao R et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 2007 Nov 16;363(2):257-62 View Abstract

[28] Sohal RS et al. Coenzyme Q, oxidative stress and aging. Mitochondrion. 2007 Jun;7 Suppl:S103-11.

[29] Schniertshauer D et al. Age-dependent loss of mitochondrial function in epithelial tissue can be reversed by Coeznyme Q10. J Aging Res. 2018 Sep 5;2018:6354680. View Full Paper

[30] Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.Aging Cell. 2015 Oct;14(5):887-95. View Full Paper

[31] Takahashi, M. Water-soluble CoQ10 as a promising, anti-aging agent for neurological dysfunction in brain mitochondria. Antioxidants (Basel). 2019 Mar 11;8(3). View Full Paper

[32] Mortensen SA et al. Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial. JACC Heart Fail. 2014 Dec;2(6):641-9. View Abstract

[33] Ishii N. Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress Mech Ageing Dev. 2004 Jan;125(1):41-6. View Abstract

[34] Aberg F et al. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys. 1992 Jun;295(2):230-4. View Abstract

[35] Ingram DK et al. Calorie restriction mimetics: Can you have your cake and eat it, too? Ageing Research Reviews 2015 20: 46–62 View Abstract

[36] Pollack RM et al. Resveratrol improves vascular function and mitochondrial number but not glucose metabolism in older adults. J Gerontol A Biol Sci Med Sci. 2017 View Abstract

[37] Tellone E et al. Resveratrol: in Nonvitamin and Nonmineral Nutritional Supplements, Academic Press 2019 View Abstract

[38] Baxter RA et al. Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.  J Cosmet Dermatol. 2008 Mar;7(1):2-7. View Abstract

[39] Valdecantos MP et al. Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different. Redox. Rep. 15 (5), 207–216. View Abstract

[40] Csiszar A, Labinskyy N, Pinto JT, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20. View Full Paper

[41] Menzies KJ, Singh K, Saleem A, Hood DA. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem. 2013 Mar 8;288(10):6968-79. View Full Paper

[42] Park D et al. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition Sci Rep. 2016 Feb 23;6:21772 View Full Paper

[43] Ahsan H et al. Pharmacological potential of tocotrienols: a review. Nutrition & Metabolism 2014. View Full Paper

[44] Kannappan R et al. Tocotrienols fight cancer by targeting multiple cell signaling pathways Genes Nutr. 2012 Jan;7(1):43-52. doi: 10.1007/s12263-011-0220-3. View Full Paper

[45] Qureshi AA et al. Dose-dependent modulation of lipid parameters, cytokines and RNA by δ-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet British Journal of Medicine & Medical Research 6(4): 351-366, 2015, Article no. BJMMR.2015.211 View Full Paper

[46] Qureshi AA et al. Suppression of nitric oxide Production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. J Clin Exp Cardiolog 2012 S5:008. View Full Paper

[47] Zou Z et al. Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion Food Chemistry 2015 ; 168: 504–511 View Abstract

[48] Panossian A et al. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.Curr Clin Pharmacol. 2009 Sep;4(3):198-219. View Abstract

[49] Cui J et al. Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species. Eur J Pharm Sci. 1999 Jul; 8(3):187-91. View Abstract

[50] Yantao Li. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan) Chin Med. 2016; 11: 43. View Full Paper

[51] Dunja S et al. Phenolic acids significantly contribute to antioxidant potency of Gynostemma pentaphyllum aqueous and methanol extracts. Industrial Crops and Products 2016 (84): 104-107 View Abstract

[52] Scholey A. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (2010) 212:345–356 View Abstract

[53] Portinho JA et al, Efeitos benéficos do açaí. Int. J. Nutrol. 2012. 5, 15–20. View Abstract

[54] Schauss, AG et al. The effect of açai (Euterpe spp.) fruit pulp on brain health and performance. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. 19) Elsevier Science. 2015. (19): 179–186. View Abstract

[55] Tahir S. Goji Berry (Lycium barbarum)— A Superfood. In: Nonvitamin and Nonmineral Nutritional Supplements. 2019 Elsevier Inc. View Abstract

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