Quicksilver Scientific

Free Shipping on Orders over $99 (Excludes )

0
0
Subtotal: 0.00

No products in the cart.

Biohacker Bundle References

 

NAD + Platinum  https://www.quicksilverscientific.com/nadplatinumreferences/

[1] Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. 

[2] Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916

[3] Keller K and Engelhardt M. Strength and muscle mass loss with the aging process. Age and strength loss. Muscles Ligaments Tendons J. 2013; 3(4): 346-350.

[4] Chang AM and Halter JB. Aging and insulin secretion. Am J Physiol Endocrinol Metab. 2003; 284(1): E7-12.

[5] Caito SW and Aschner M. NAD+ Supplementation attenuates methylmercury dopaminergic and mitochondrial toxicity in Caenorhabditis Elegans. Toxicol Sci. 2016; 151(1): 139-149.

[6] Gizem Kivrak E, et al. Effects of electromagnetic fields exposure on the antioxidant defense system. J Microsc Ultrastruct. 2017; 2017; 5(4): 167-176.

[7] Xie N, et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020; 5: 227.

[8] Hong W, et al. Nicotinamide mononucleotide: A promising molecule for therapy of diverse diseases by targeting NAD+ metabolism. Front Cell Dev Biol. 2020.

[9] Wu, L et al. The elusive NMN transporter is found. Nat Metab 2019: 1; 8-9

[10] Yamaguchi S and Yoshino J. Adipose tissue NAD+ biology in obesity and insulin resistance: From mechanism to therapy. Bioessays. 2017; 39(5): 10.1002/bies.201600227.

[11] Guarente L, Franklin H. Epstein lecture: sirtuins, aging, and medicine. N Engl J Med. (2011) 364:2235–44.

[12] Kane AE, Sinclair DA. Sirtuins and NAD+ in the development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018; 123:868-885.

[13] Mangerich A, et al. Pleiotropic cellular functions of PARP1 in longevity and aging: Genome maintenance meets inflammation. Oxid Med Cell Longev. 2012; 2012: 321653.

[14] Bonkowski MS and Sinclair D. Slowing aging by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016; 17(11): 679-690.

[15] Lewinska A, et al. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. Redox Biol. 2020; 28: 101337.

[16] Jesko H, et al. Sirtuins and their roles in brain aging and neurodegenerative disorders. Neurochem Res. 2017; 42(3): 876-890.

[17] Warren JL, et al. Regulation of adaptive immune cells by sirtuins. Front Endocrinol (Lausanne). 2019; 10:466.

[18] Radak Z, et al. The systemic role of SIRT1 in exercise mediated adaptation. Redox Biol. 2020; 35: 101467.

[19] Vargas-Ortiz K, et al. Exercise and sirtuins: A way to mitochondrial health in skeletal muscle. Int J Mol Sci. 2019; 20(11): 2717.

[20] Asher G, et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2): 317-328.

[21] Grabowska W, et al. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017; 18(4): 447-476.

[22] Schafer MJ, et al. Exercise prevents diet-induced cellular senescence in adipose tissue. Diabetes. 2016; 65(6): 1606-1615.

[23] Han YM, et al. β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4.Mol Cell. 2018; 71(6): 1064-1078.

[24] Weng Z, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012; 7(3): e33805.

[25] Mohar DS and Malik S. The sirtuin system: The holy grail of resveratrol? J Clin Exp Cardiol. 2012; 3(11): 216.

[26] Hustad S, et al. Riboflavin and methylenetetrahydrofolate reductase. Madame Curie Bioscience Database. 2013.

[27] Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36 View Full Paper

[28] Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier.  Int J Nanomedicine. 2014 Feb 7;9:795-811 View Full Paper

 

Membrane Mend™  https://www.quicksilverscientific.com/membranemendreferences/

[1] Casares D, et al. Membrane lipid composition: Effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues. Int J Mol Sci. 2019; 20(9): 2167.

[2] Leekumjorn S, et al. The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. Biochim Biophys Acta. 2009; 1788(7): 1508-1516.

[3] Van Meer G, et al. Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol. 2009; 9(2): 112-124.

[4] Zorova LD, et al. Mitochondrial membrane potential. Anal Biochem. 2018; 552: 50-59.

[5] Chew S, et al. Impairment of mitochondrial function by particulate matter: Implications for the brain. Neurochem Int. 2020; 135(104694).

[6] Zulkifli-Cunningham Z, et al. Clinical effects of chemical exposures on mitochondrial function. Toxicology. 2017; 391: 90-99.

[7] Lin JH, et al. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol. 2008; 3: 399-425.

[8] Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010; 140(6): P900-P917.

[9] Kalghatgi S, et al. Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells. Sci Transl Med. 2013; 5(192): 192ra85.

[10] Santini SJ, et al. Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems. Oxid Med Cell Longev. 2018; 2018: 5076271.

[11] Zorova LD, et al. Mitochondrial membrane potential. Anal Biochem. 2018; 552: 50-59.

[12] Nicolson GL, et al. Clinical uses of membrane lipid replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer. Discoveries (Craiova). 2016; 4(1): e54.

[13] Na JY, et al. Hepatoprotective effect of phosphatidylcholine against carbon tetrachloride liver damage in mice. Biochem Biophys Res Commun. 2015; 460(2): 308-313.

[14] Maev IV, et al. Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study). BMJ Open Gastroenterol. 2020; 7: e000341.

[15] Kennelly JP, et al. Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis. J Lipid Res. 2018; 59(9): 1695-1708.

[16] Schneider H, et al. Lipid-based therapy for ulcerative colitis—Modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation. Int J Mol Sci. 2010; 11(10): 4149-4164.

[17] Chen M, et al. Oral phosphatidylcholine improves intestinal barrier function in drug-induced liver injury in rats. Gastroenterol Res Pract. 2019; Article ID 8723460.

[18] Lichtenberger LM. Role of phospholipids in protection of the GI mucosa. Digestive Dis Sci. 2013; 58: 891-893.

[19] Blusztajn JK, et al. Neuroprotective actions of dietary choline. Nutrients. 2017; 9(8): 815.

[20] Ojo JO, et al. Disruption in brain phospholipid content in a humanized tau transgenic model following repetitive mild traumatic brain injury. Front Neurosci. 2018; [online].

[21] Yu C, et al. HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells. J Cell Molec Med. 2019; 23(5): 3140-3150.

[22] Wen G, et al. Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes. PLoS One. 2017; [online].

[23] Lefort N, et al. Dietary Buglossoides Arvensisoil increases circulating n-3 polyunsaturated fatty acids in a dose-dependent manner and enhances lipopolysaccharide-stimulated whole blood interleukin-10—A randomized placebo-controlled trial. Nutrients. 2017; 9(3): 261.

[24] Lefort N, et al. Consumption of Buglossoides arvensis seed oil is safe and increases tissue long-chain n-3 fatty acid content more than flaxseed oil – results of a phase I randomised clinical trial. J Nutr Sci. 2016; 5: e2.

[25] Sztretye M, et al. Astaxanthin: A potential mitochondrial-targeted antioxidant treatment in diseases and with aging. Oxid Med Cell Longev. 2019; 2019: 3849692.

 

The One References https://www.quicksilverscientific.com/theonereferences/

[1] Ryan MT. Mitochondria – the energy powerhouses. Semin Cell Dev Biol. 2018 Apr;76:130-131. View Abstract

[2] Linnane AW et al. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 1989 Mar 25;1(8639):642-5 View Abstract

[3] Harris CB. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013 Dec;24(12):2076-84. View Full Paper

[4] Sharma A. Coenzyme Q10 and heart failure: a state of the art review. Circ Heart Fail. 2016 Apr;9(4):e002639. View Full Paper

[5] Vaquero EC et al. Tocotrienols: balancing the mitochondrial crosstalk between apoptosis and autophagy. Autophagy. 2007 Nov-Dec;3(6):652-4. View Abstract

[6] De Oliveira MR et al. Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view. Biochim Biophys Acta. 2016 Apr;1860(4):727-45. View Abstract

[7] Panossian A et al. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219 View Abstract

[8] Saihara K et al. Pyrroloquinoline Quinone, a redox-active o-Quinone, stimulates mitochondrial biogenesis by activating the SIRT1/PGC-1α signaling pathway. Biochemistry. 2017 Dec 19;56(50):6615-6625 View Abstract

[9] Pang KL et al. The role of tocotrienol in protecting against metabolic diseases. Molecules. 2019 Mar 6;24(5). View Full Paper

[10] Springer M et al. Resveratrol and its human metabolites-effects on metabolic health and obesity. Nutrients. 2019 Jan 11;11(1). pii: E143. View Full Paper

[11] Most J et al. Calorie restriction in humans: An update. Ageing Res Rev. 2017 Oct;39:36-45 View Full Paper

[12] National Institute of General Medical Sciences. Inside the Cell. Available at: https://www.nigms.nih.gov/education/Booklets/Inside-the-Cell/Pages/Home.aspx Accessed 10-17-2019

[13] Zhou Z et al. Mitochondrial metabolism in major neurological diseases. Cells. 2018 Nov 23;7(12). View Full Paper

[14] Dunn D et al. Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol. 2015 Dec;6:472-485. View Full Paper

[15] Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annu Rev Genet. 2005;39:359-407. View Full Paper

[16] Zhang Y, Xu H. Translational regulation of mitochondrial biogenesis. Biochem Soc Trans. 2016 Dec 15;44(6):1717-1724. View Abstract

[17] Meyer JN et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. View Full Paper

[18] Misra HS et al. Pyrroloquinoline-quinone and its versatile roles in biological processes. J Biosci 2012;37:313–25 View Abstract

[19] Chowanadisai W et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem 2010;285:142–52. View Full Paper

[20] Villegas R et al. Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.Ann Hum Genet. 2014 Jan;78(1):23-32 View Abstract

[21] Bauerly K et al. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One 2011;6:e21779 View Full Paper

[22] Rucker R et al. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009 Sep;14(3):268-77 View Abstract

[23] Stites T et al. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. J Nutr. 2006 Feb;136(2):390-6. View Abstract

[24] Wen H et al. Mini-review; functions and action mechanisms of PQQ in osteoporosis and neuro injury. Neurosci Lett. 2018 Nov 20;687:104-110 View Abstract

[25] Zhang Q, Ding M, Gao XR, Ding F. Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes. Genet Mol Res. 2012 Aug 16;11(3):2652-64. View Abstract

[26] Zhu BQ et al. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006 Jun;11(2):119-28 View Abstract

[27] Tao R et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 2007 Nov 16;363(2):257-62 View Abstract

[28] Sohal RS et al. Coenzyme Q, oxidative stress and aging. Mitochondrion. 2007 Jun;7 Suppl:S103-11.

[29] Schniertshauer D et al. Age-dependent loss of mitochondrial function in epithelial tissue can be reversed by Coeznyme Q10. J Aging Res. 2018 Sep 5;2018:6354680. View Full Paper

[30] Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.Aging Cell. 2015 Oct;14(5):887-95. View Full Paper

[31] Takahashi, M. Water-soluble CoQ10 as a promising, anti-aging agent for neurological dysfunction in brain mitochondria. Antioxidants (Basel). 2019 Mar 11;8(3). View Full Paper

[32] Mortensen SA et al. Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial. JACC Heart Fail. 2014 Dec;2(6):641-9. View Abstract

[33] Ishii N. Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress Mech Ageing Dev. 2004 Jan;125(1):41-6. View Abstract

[34] Aberg F et al. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys. 1992 Jun;295(2):230-4. View Abstract

[35] Ingram DK et al. Calorie restriction mimetics: Can you have your cake and eat it, too? Ageing Research Reviews 2015 20: 46–62 View Abstract

[36] Pollack RM et al. Resveratrol improves vascular function and mitochondrial number but not glucose metabolism in older adults. J Gerontol A Biol Sci Med Sci. 2017 View Abstract

[37] Tellone E et al. Resveratrol: in Nonvitamin and Nonmineral Nutritional Supplements, Academic Press 2019 View Abstract

[38] Baxter RA et al. Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.  J Cosmet Dermatol. 2008 Mar;7(1):2-7. View Abstract

[39] Valdecantos MP et al. Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different. Redox. Rep. 15 (5), 207–216. View Abstract

[40] Csiszar A, Labinskyy N, Pinto JT, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20. View Full Paper

[41] Menzies KJ, Singh K, Saleem A, Hood DA. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem. 2013 Mar 8;288(10):6968-79. View Full Paper

[42] Park D et al. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition Sci Rep. 2016 Feb 23;6:21772 View Full Paper

[43] Ahsan H et al. Pharmacological potential of tocotrienols: a review. Nutrition & Metabolism 2014. View Full Paper

[44] Kannappan R et al. Tocotrienols fight cancer by targeting multiple cell signaling pathways Genes Nutr. 2012 Jan;7(1):43-52. doi: 10.1007/s12263-011-0220-3. View Full Paper

[45] Qureshi AA et al. Dose-dependent modulation of lipid parameters, cytokines and RNA by δ-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet British Journal of Medicine & Medical Research 6(4): 351-366, 2015, Article no. BJMMR.2015.211 View Full Paper

[46] Qureshi AA et al. Suppression of nitric oxide Production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. J Clin Exp Cardiolog 2012 S5:008. View Full Paper

[47] Zou Z et al. Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion Food Chemistry 2015 ; 168: 504–511 View Abstract

[48] Panossian A et al. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.Curr Clin Pharmacol. 2009 Sep;4(3):198-219. View Abstract

[49] Cui J et al. Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species. Eur J Pharm Sci. 1999 Jul; 8(3):187-91. View Abstract

[50] Yantao Li. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan) Chin Med. 2016; 11: 43. View Full Paper

[51] Dunja S et al. Phenolic acids significantly contribute to antioxidant potency of Gynostemma pentaphyllum aqueous and methanol extracts. Industrial Crops and Products 2016 (84): 104-107 View Abstract

[52] Scholey A. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (2010) 212:345–356 View Abstract

[53] Portinho JA et al, Efeitos benéficos do açaí. Int. J. Nutrol. 2012. 5, 15–20. View Abstract

[54] Schauss, AG et al. The effect of açai (Euterpe spp.) fruit pulp on brain health and performance. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. 19) Elsevier Science. 2015. (19): 179–186. View Abstract

[55] Tahir S. Goji Berry (Lycium barbarum)— A Superfood. In: Nonvitamin and Nonmineral Nutritional Supplements. 2019 Elsevier Inc. View Abstract

0
    0
    Your Cart
    You're 99.00 away from free shipping.
    Your cart is empty
      Calculate Shipping
      Apply Coupon

      to your account for access to our

      Memorial Day

      Weekend Sale!

      Don’t have an account? Sign up here!