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Deluxe Detox Qube References

Methyl B-Complex References https://www.quicksilverscientific.com/methylbcomplexreferences/

  1. Day CR et al. Betaine chemistry, roles, and potential use in liver disease. Biochimica et Biophysica Acta (BBA) 2016. (1860):6: Pages 1098-1106 View Abstract
  2. Kawaguchi-Suzuki M et al. The effects of milk thistle (Silybummarianum) on human cytochrome p450 activity. Drug MetabDispos. 2014 Oct; 42(10): 1611–1616. View Full Paper
  3. Ma Y et al. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases. BMC Cardiovasc Disord. 2017;17(1):37.View Full Paper
  4. Antoniades CS et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J. 2009;30:6–15 View Abstract
  5. Wagner C. Biochemical role of folate in cellular metabolism. In: Bailey LB, ed. Folate in Health and Disease. New York: Marcel Dekker Inc; 1995:23–42 View Abstract
  6. Smith AD et al.  Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 2010;5:e12244 View Abstract
  7. Ford TC et al. The effect of a high-dose vitamin B multivitamin supplement on the relationship between brain metabolism and blood biomarkers of oxidative stress: a randomized control trial. Nutrients. 2018 Dec; 10(12): 1860 View Full Paper
  8. Peters RA. The vitamin B complex. Br Med J. 1936 Nov 7; 2(3957): 903–905.
  9. B vitamins. Harvard T.H. Chan School of Public Health , The Nutrition Source, Vitamins and Minerals > B Vitamins. Available at: https://www.hsph.harvard.edu/nutritionsource/vitamins/vitamin-b/ (Accessed July 4, 2019)
  10. James JS, Melnyk S et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1): 425–430 View Full Paper
  11. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients. 2016;8(2):68 View Full Paper
  12. Du J et al.The role of nutrients in protecting mitochondrial function and neurotransmitter signaling: implications for the treatment of depression, PTSD, and suicidal behaviors. Crit Rev Food Sci Nutr 2014: 2560-2578View Full Paper
  13. Kennedy DO. B vitamins and the brain: mechanisms, dose and efficacy—a review. Nutrients. 2016 Feb; 8(2): 68 View Full Paper
  14. Unpublished data, Quicksilver ScientificTM, B12 crossover study
  15. Stabler SP et al. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest. 1998;81:466–474 View Full Paper
  16. Baik HW et al. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-77 View Full Paper
  17. de Jager J  et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.BMJ. 2010 May 20;340:c2181 View Full Paper
  18. Valuck RJ et al. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults J Clin Epidemiol. 2004 Apr;57(4):422-8 View Astract
  19. Vitamin B12 Fact Sheet for Consumers. June 24 2011 (cited 17 July 2017). Available from: https://ods.od.nih.gov/factsheets/VitaminB12-Consumer/
  20. Raczynski G et al. Longitudinal studies on vitamin B-1 and  status in Polish elite athletes. Biol. Sport. 10:189-194, 1993 View Abstract
  21. Miller DF. Pellagra deaths in the United States. The American Journal of Clinical Nutrition, 1978. 31(4), 558–559 View Abstract
  22. Pacul C et al. Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms. Integr Med (Encinitas). 2017 Feb;16(1):42-49 View Full Text
  23. Qin B et al. Intake of niacin, folate, vitamin , and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study.Am J Clin Nutr. 2017 Oct;106(4):1032-1040 View Full Paper
  24. Li S, Chen X, Li Q, Du J et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial.J Diabetes Investig. 2016 Sep;7(5):777-85.  View Full Paper
  25. Korem M et al. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences 2005: 233: 93 – 97View Abstract
  26. Zhang Y et al. Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia. PLoS One. 2016 Jan 22;11(1):e0146797. View Full Paper
  27. Kwok T et al. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr. 2011 Jun;30(3):297-302. View Abstract
  28. TKasuya M. The effect of methylcobalamin on the toxicity of methylmercury and mercuric chloride on nervous tissue in culture. Toxicol Lett. 1980 Nov;7(1):87-93. View Abstract
  29. Smith AD et al. Vitamin B12. In: Advances in Food and Nutrition Research, Volume 83. Elsevier. 2018
  30. Ma Y et al. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases. BMC Cardiovasc Disord. 2017;17(1):37.View Full Paper
  31. Hoffman M. Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. Med Hypotheses. 2011;77:1088–93. View Abstract
  32. McCaddon A et al. L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer’s disease-related cognitive decline. CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5; discussion 6. Review. View Abstract
  33. Antoniades C et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J. 2009;30:6–15. View Abstract
  34. Moore LD et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38.View Full Paper
  35. Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol. 2008;15(2):72–75. View Full Paper
  36. Shames DS, Minna JD et al. DNA methylation in health, disease, and cancer. Curr Mol Med 7: 85-102View Full Paper
  37. Borowa-Mazgaj B et al. Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicol Sci. 2019 May 14. pii: kfz110 View Full Paper
  38. Ligthart S et al.  DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255 View Full Paper
  39. Murphy TM et al. Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes Psychiatr Genet. 2015 Apr;25(2):71-8. View Abstract
  40. NIH U.S. National Library of Medicine, MTHFR gene. Genetics Home Reference Available at: https://ghr.nlm.nih.gov/gene/MTHFR Accessed 1-4-2020
  41. Castro R et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. Journal of Medical Genetics 2004;41:454-458View Full Paper
  42. McGuire BW et al. Pharmacokinetics of leucovorin calcium after intravenous, intramuscular, and oral administration. Clin Pharm 1988;7(1):52-58. [View Abstract]
  43. Malouf R et al. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev 2008;4:CD004514 View Abstract
  44. Smith AD et al.  Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 2010;5:e12244. View Full Paper
  45. Wang X et al. X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 2007;369:1876–82. View Abstract
  46. Malouf R, Grimley EJ.  The effect of vitamin B-6 on cognition. Cochrane Database Syst Rev 2006; (4):CD004393.
  47. Wang HX et al. Vitamin B(12) and folate in relation to the development of Alzheimer’s disease. Neurology 2001;56(9):1188–94.View Abstract
  48. Lewis J et al. The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression. ISRN Psychiatry 2013 Jan 21;2013:621453View Full Paper
  49. McNulty H et al. Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status. British Journal of Nutrition. 2008:99, Suppl. 3, S48–S54 View Abstract
  50. Spence JD. Nutrition and stroke prevention. Stroke 2006; 37: 2430–35.View Full Paper
  51. Coimbra CG et al. High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson’s disease patients. Brazilian Journal of Medical and Biological Research. 2003: 36(10), 1409–1417 View Abstract
  52. Wakade C et al. Niacin modulates macrophage polarization in Parkinson’s disease. J Neuroimmunol. 2018 Jul 15;320:76-79 View Abstract
  53. Wakade C et al. A novel treatment target for Parkinson’s disease J Neurol Sci. 2014 Dec 15;347(1-2):34-8 View Abstract
  54. Boehnke C et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: An open study in a tertiary care centre. European Journal of Neurology. 2004:11(7): 475–477. View Abstract
  55. Sedel F et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. MultSclerRelatDisord. 2015 Mar;4(2):159-69 View Abstract
  56. Pavlin M, Repic M et al. The chemistry of neurodegeneration: kinetic data and their implications. Mol Neurobiol 2015: (53):5: 3400–3415View Abstract
  57. Manore, MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am. J. Clin. Nutr. 2000: 72:598S-606S View Abstract
  58. Manore, MM. Nutritional needs of the female athlete. In Clinics in Sports Medicine: Nutritional Aspects of Exercise, K.B. Wheeler, and J.A. Lombardo (Eds.). Philadelphia: W.B. Sanders Company, 1999: 549-563.
  59. Fogelholm, M. Micronutrient status in females during a 24-week fitness-type exercise program. Ann. Nutr. Metab. 1992: 36:209-218 View Abstract
  60. Rokitzki L et al. Assessment of vitamin B-6 status of strength and speedpower athletes. J. Am. Coll. Nutr. 1994: 13:87-94 View Abstract
  61. Winters LR et al. Riboflavin requirements and exercise adaptation in older women. Am. J. Clin. Nutr. 1992: 56:526-532 View Abstract
  62. Raczynski G et al. Longitudinal studies on vitamin B-1 and B-6 status in Polish elite athletes. Biol. Sport. 1993: 10:189-194. View Abstract
  63. Telford RD et al. The effect of 7 to 8 months of vitamin/mineral supplementation on the vitamin and mineral status of athletes. Int. J. Sport Nutr. 1992: 2:123-134 View Abstract
  64. Abdou E et al. Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations. Neurochem Res 2014: (40): 2: 353–361View Abstract
  65. Ashoori M Riboflavin (vitamin B(2)) and oxidative stress: a review. Br J Nutr 2014: 111:1985–1991 View Abstract
  66. Digby JE et al. Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms. ArteriosclerThrombVasc Biol 2012: 32:669–676. View Abstract
  67. Morris JS et al. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. Journal of Nutrition, 2010: 140; 103–110. View Full Paper
  68. Mikkelsen K, Stojanovska L et al. The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas 2017; 96:58–71. View Abstract
  69. Baynes JW et al. Glycoxidation and lipoxidation in atherogenesis. Free Radical Biology & Medicine 2000: 28; 1708–1716 View Abstract
  70. Zhao G, He F. Betaine in inflammation: mechanistic aspects and applications. Front Immunol. 2018 May 24;9:1070 View Full Paper
  71. Federico A. Silymarin/Silybin and chronic liver disease: a marriage of many years. Molecules. 2017 Jan 24;22(2). pii: E191View Full Paper
  72. Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35View Full Paper
  73. Chang CY et al. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41View Abstract
  74. Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93View Full Paper
  75. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36View Full Paper
  76. Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier.  Int J Nanomedicine. 2014 Feb 7;9:795-811View Full Paper

 

Clear Way Cofactors® References https://www.quicksilverscientific.com/clearwaycofactorsreferences/

  1. Upadhyay A, et al. A review on the pharmacological aspects of Terminalia chebula. Int J Pharmacol. 10(6): 289-298.
  2. Mahesh R, et al. Effect of Terminalia Chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochem Funct. 2009; 27(6): 358-363.
  3. Saha S, Verma RJ. Antioxidant activity of polyphenolic extract of Terminalia chebula Retzius J Taibah Univ Sci. 2016; 10(6): 805-812.
  4. Bag A, et al. Anti-inflammatory, anti-lipid peroxidative, antioxidant and membrane stabilizing activities of hydroalcoholic extract of Terminalia chebula Pharm. 2013; 52(12): 1515-1520.
  5. Feng J, et al. Pinus Massoniana bark extract: Structure-activity relationship and biomedical potentials. Am J Chin Med. 2016; 44(8): 1559-1577.
  6. Wang C, et al. Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a d-galactose-induced mouse model. Age (Dordr). 2014; 36(4)9676.
  7. Mandal A, et al. Anti-inflammatory mechanism involved in pomegranate-mediated prevention of breast cancer: The role of NF-κB and Nrf2 signaling pathways. Nutrients. 2017; 9(5): 436.
  8. Singh R, et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 2019; 10(89).
  9. Sun YQ, et al. In vitro and in vivo antioxidant activities of three major polyphenolic compounds in pomegranate peel: Ellagic acid, punicalin, and punicalagin. J Integr Agr. 2017; 16(8): 1808-1818.
  10. Mairuae N, et al. Anti-inflammatory and anti-oxidative effects of Centella asiatica extract in lipopolysaccharide-stimulated BV2 microglial cells. Pharmacogn. 2019; 15(60): 140-146.
  11. Christinal J, Sumathi T. Effect of Bacopa Monniera extract on methylmercury-induced behavioral and histopathological changes in rats. Biol Trace Elem Res. 2013; 155(1): 56-64.
  12. Gonzalez-Castejon M, et al. Diverse biological activities of dandelion. Nutr Rev. 70(9): 534-547.
  13. Liu B, et al. Taraxasterol inhibits LPS-induced inflammatory response in BV2 microglia cells by activating LXRα. Front Pharmacol. 2018; 9: 278.
  14. Esatbeyoglu T, et al. Sesquiterpene lactone composition and cellular Nrf2 induction of Taraxacum officinale leaves and roots and Taraxinic Acid β-d-Glucopyranosyl Ester. J Med Food. 2017; 20(1): 71-78.
  15. Chandra N, et al. Bacterial biofilms in human gastrointestinal tract: An intricate balance between health and inflammatory bowel diseases. World J Pharmacol. 2019; 8(3): 26-40.
  16. Marsh PD, Zaura E. Dental biofilm: ecological interactions in health and disease. J Clin Periodontol. 2017; 44(S18): S12-S22.
  17. Jamal M, et al. Bacterial biofilm and associated infections. J Chin Med Assoc. 2018; 81(1): 7-11.
  18. Kurosawa Y, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015; 5: 11601.
  19. Iwamoto A, et al. The Japanese fermented food natto inhibits sucrose-dependent biofilm formation by cariogenic Streptococci. Food Sci Technol Res. 2018; 24(1): 129-137.
  20. Salehi B, et al. Insights on the use of α-lipoic acid for therapeutic purposes. Biomolecules. 2019; 9(8): 356.
  21. Lonsdale D, et al. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett. 2002; 23(4): 303-308.
  22. Reddy SY, et al. Thiamine reduces tissue lead levels in rats: mechanism of interaction. Biometals. 2010; 23(2): 247-253.
  23. Flora SJ, and Sharma RP. Influence of dietary supplementation with thiamine on lead intoxication in rats. Biol Trace Elem Res. 1986; 10(2): 137-144.
  24. Slyshenkov VS, et al. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004; 569(1-3): 169-172.
  25. Eidi A, et al. Hepatoprotective effects of pantothenic acid on carbon tetrachloride-induced toxicity in rats. EXCLI J. 2012; 11: 748-759.
  26. Hsu CC, et al. Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress. Food Nutr Res. 2015; 59: 25702.
  27. Tandon SK, et al. Influence of pyridoxine (vitamin B6) on lead intoxication in rats. Ind Health. 1987; 25(2): 93-96.
  28. Ursini F and Bindoli A. The role of selenium peroxidases in the protection against oxidative damage of membranes. Chem Phys Lipids. 1987; 44(2-4): 255-276.
  29. Spiller HA. Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clin Toxicol. 2018; 56(5): 313-326.

 

EDTA References https://www.quicksilverscientific.com/edtaroreferences/

  1. Fabbrizzi L. Living in a cage is a restricted privilege. Top Curr Chem. 2012;323:127-66. View Abstract
  2. Suh JH. Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Redox Rep. 2005;10(1):52-60. View Abstract
  3. Kartal SN. Removal of copper, chromium, and arsenic from CCA-C treated wood by EDTA extraction. Waste Management. 2003 Dec 31;23(6):537-46. View Abstract
  4. De Gregori I et al. Extractable copper, arsenic and antimony by EDTA solution from agricultural Chilean soils and its transfer to alfalfa plants (Medicago sativa L.). J Enviro Monitor 2004;6(1):38-47. View Full Paper
  5. Patrick L et al. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.Altern Med Rev. 2002 Dec;7(6):456-71. View Full Paper
  6. Flora SJ et al. Heavy metal induced oxidative stress & its possible reversal by chelation therapy Indian J Med Res. 2008 Oct;128(4):501-23. View Abstract
  7. Ziegler EE et al. Absorption and retention of lead by infants. Pediatr Res. 1978 Jan; 12(1):29-34. View Article
  8. Jan AT et al. Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. Int J Mol Sci. 2015;16(12):29592–29630 View Full Paper
  9. Flora S. Arsenic-induced oxidative stress and its reversibility. Free Radic. Biol. Med. 2011;51:257–281. View Abstract
  10. Ferrero ME. Rationale for the successful management of EDTA chelation therapy in human burden by toxic metals. Biomed Res Int. 2016;2016:8274504. View Full Paper
  11. Aheran GA et al. Mechanisms of heavy-metal sequestration and detoxification in crustaceans: a review.J Comp Physiol B. 2004 Aug;174(6):439-52. View Abstract
  12. Salehi B. Insights on the use of α-Lipoic acid for therapeutic purposes. Biomolecules. 2019 Aug 9;9(8). View Full Paper
  13. Seifar F. α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review. Nutr Neurosci. 2019 May;22(5):306-316. View Abstract
  14. Flora SJ et al. Chelation in metal intoxication. Int J Environ Res Public Health. 2010;7(7):2745–2788 View Full Paper
  15. Foreman H et al. The metabolism of C14 labeled ethylene diamino tetraacetic acid in human beings. J Lab Clin Med. 1954;43:566–571. [View Abstract]
  16. Andersen O. Principles and recent developments in chelation treatment of metal intoxication. Chem Rev. 1999 Sep 8;99(9):2683-710. View Full Paper
  17. Jonah MM et al. Tissue of EDTA encapsulated within liposomes of varying surface Biochim Biophys Acta. 1975 Sep 2;401(3):336-48 View Abstract
  18. Jonah MM et al. Tissue distribution of EDTA encapsulated within liposomes containing glycolipids or brain phospholipids. Biochim Biophys Acta. 1978 Jul 3;541(3):321-33. View Abstract
  19. Patrick L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Altern Med Rev. 2002 Dec;7(6):456-71. View Full Paper
  20. Breithaupt-Grogler K et al. Dose-proportionality of oral thioctic acid–coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci. 1999;8(1):57-65.View Abstract
  21. Schelkonogov VA et al. Liposomal form of lipoic acid: preparation and determination of antiplatelet and antioxidant activity Biomed Khim. 2016 Jul;62(5):577-583. View Abstract
  22. Külkamp IC. J Biomed Nanoencapsulation improves the in vitro antioxidant activity of lipoic acid.
  23. 2011 Aug;7(4):598-607. View Abstract
  24. Cranton EM et al. Free oxygen radical pathology and EDTA chelation therapy: mechanisms of action. Journal of Advancement in Medicine. 1998;11(4):277–310. View Full Paper
  25. Miller KL et al. Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches. Am Heart J. 2004 Mar; 147(3):401-11. View Abstract
  26. Roussel AM et al. EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation.Altern Med Rev. 2009 Mar;14(1):56-61. View Abstract
  27. VE Kagan et al.Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase
  28. Biochem Pharmacol, 44 (1992), pp. 1637-1649 View Abstract
  29. Shay KP et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790:1149–1160. View Full Paper
  30. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. J Clin Biochem Nutr. 2015 Jul; 57(1): 21–26 View Abstract
  31. Goralska M et al. Alpha lipoic acid changes iron uptake and storage in lens epithelial cells. Exp. Eye Res. 2003, 76, 241–248. View Abstract
  32. Sun H et al. Alphalipoic Acid Prevents Oxidative Stress and Peripheral Neuropathy in Nab-Paclitaxel-Treated Rats through the Nrf2 Signalling Pathway. Oxid Med Cell Longev. 2019 Feb 10;2019:3142732. View Full Paper
  33. Rocamonde B et al. Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury. Neuroscience2012;224:102–115. View Abstract
  34. Seifer F et al. α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review. Nutr Neurosci. 2019 May;22(5):306-316 View Abstract
  35. Sloth-Nielsen J et al. Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis. Am J Surg. 1991 Aug;162(2):122-5. View Abstract
  36. Lamas GA et al. EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy.
  37. Am Heart J. 2014 Jul;168(1):37-44.e5. View Full Paper
  38. Chen KH et al. Effect of chelation therapy on progressive diabetic nephropathy in patients with type 2 diabetes and high-normal body lead burdens Am J Kidney Dis. 2012 Oct;60(4):530-8. View Abstract
  39. Zanella SG. Personalization of multiple sclerosis treatments: using the chelation therapy approach.Explore (NY). 2013 Jul-Aug;9(4):244-8. View Abstract
  40. Dinicola S et al. Alpha-Lipoic Acid downregulates IL-1 and IL-6 by DNA hypermethylation in SK-N-BE neuroblastoma cells. Antioxidant 2017, 6, 74. View Abstract
  41. Khalili M et al. Does lipoic acid consumption a_ect the cytokine profile in multiple sclerosis patients: A double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation 2014, 21, 291–296. View Abstract
  42. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995 Aug;19(2):227-50. View Abstract
  43. Bustamante J, Lodge JK, Marcocci L, et al. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998 Apr;24(6):1023-39. View Abstract
  44. Gurer H, et al. Antioxidant role of alpha-lipoic acid in lead toxicity. Free Radic Biol Med. 1999 Jul;27(1-2):75-81. View Abstract
  45. Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35 View Full Paper
  46. Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93 View Full Paper
  47. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016 Nov 23;20:36 View Full Paper
  48. Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811 View Full Paper

 

IMD References quicksilverscientific.com/imdreferences/

  1. Clifton JC., 2nd Mercury exposure and public health. Pediatr Clin North Am. 2007;54(2):237–269. View Abstract
  2. US Department of Health and Human Services, Public Health Service. Toxicological profile for mercury. Atlanta: US Department of Health and Human Services; 1999. pp. 1–600.  View Abstract  
  3. Rice KM et al Environmental mercury and its toxic effects. J Prev Med Public Health. 2014;47(2):74–83. View Full Paper
  4. Berlin M et al. Accumulation and retention of mercury in the mouse: III. An autoradiographic comparison of methylmercuric dicyandiamide with inorganic mercury. Arch Environ Health 6:610, 1963. View Abstract
  5. Norseth T et al. Intestinal transport of 203Hg-labeled methyl mercury chloride: Role of biotransformation in rats. Arch Environ Health 22:568-577, 1971 View Abstract
  6. Clarkson TW et al. Excretion and absorption of methyl mercury after polythiol resin treatment. Arch Environ Health. 1973 Apr;26(4):173-6. View Abstract
  7. Clarkson TW. The three modern faces of mercury. Environ Health Perspect 2002;110:11-23. View Full Paper
  8. Deneke SM. Thiol-based antioxidants. Curr Top Cell Regul. 2000;36:151-80. View Abstract
  9. Berglund F et al. Risk of methyl mercury cumulation in man and mammals and the relation between body burden of methyl mercury and toxic effects, in Miller M, Berg GG (eds): Chemical Fallout. Springfield, Ill, Charles C Thomas Publisher, 1969, p 258.
  10. Sangvanich T. Novel oral detoxification of mercury, cadmium, and lead with thiol-modified nanoporous silica. ACS Appl Mater Interfaces. 2014 Apr 23;6(8):5483-93. View Full Paper
  11. Gill R et al. Low level exposure to inorganic mercury interferes with B cell receptor signaling in transitional type 1 B cells. Toxicol Appl Pharmacol. 2017 Sep 1;330:22-29. View Abstract
  12. Guardiola FA et al. Mercury accumulation, structural damages, and antioxidant and immune status changes in the Gilthead Seabream (Sparus aurata L.) exposed to methylmercury. Arch Environ Contam Toxicol. 2016 May;70(4):734-46. View Abstract
  13. Desforges JP et al. Immunotoxic effects of environmental pollutants in marine mammals. Environ Int. 2016 Jan;86:126-39. View Abstract
  14. de Vos G et al. Selective effect of mercury on Th2-type cytokine production in humans. Immunopharmacol Immunotoxicol. 2007;29(3-4):537-548. View Abstract
  15. Crowe W et al. Mercury as an environmental stimulus in the development of autoimmunity – A systematic review. Autoimmun Rev. Jan 2017;16(1):72-80 View Abstract
  16. Clarkson TW. The toxicology of mercury. Crit Rev Clin Lab Sci. 1997;34(4):369-403.
  17. Morris G et al. The putative role of environmental mercury in the pathogenesis and pathophysiology of autism spectrum disorers and subtypes. Mol Neurobiol. 2017 Jul 22. View Abstract
  18. Geier DA, Kern JK, Geier MR Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. J Trace Elem Med Biol. 2017 Jul;42:18-24. View Abstract
  19. Pantaleão TU, Ferreira ACF, Santos MCS et al. Effect of thimerosal on thyroid hormones metabolism in rats. Endocr Connect. 2017 Nov;6(8):741-74 View Full Paper
  20. Zhu X, Kusaka Y, Sato K, et al. The endocrine disruptive effects of mercury. Environ Health Prev Med. 2000 Jan;4(4):174-83. View Full Paper
  21. Kisakol G. Dental amalgam implantation and thyroid autoimmunity Bratisl Lek Listy. 2014;115(1):22-4. View Abstract
  22. Iavicoli I, Fontana L, Bergamaschi A. The effects of metals as endocrine disruptors. J Toxicol Environ Health B Crit Rev. Mar 2009;12(3):206-223.
  23. Zeng Q, Feng W, Zhou B Urinary metal concentrations in relation to semen quality: a cross-sectional study in China. Environ Sci Technol. 2015 Apr 21;49(8):5052-9. View Abstract
  24. Buck Louis GM, Smarr MM, Sundaram R et al. Low-level environmental metals and metalloids and incident pregnancy loss. Reprod Toxicol. 2017 Apr;69:68-74. View Abstract
  25. Mieiro CL, Pereira ME, Duarte AC, Pacheco M. Brain as a critical target of mercury in environmentally exposed fish (Dicentrarchus labrax)–bioaccumulation and oxidative stress profiles. Aquat Toxicol. 2011;103:233–240. [PubMed] [Google Scholar]
  26. Kim JS, et al. Increased serum glutamate in depressed patients. Arch Psychiatr Nervenkr. 1982;232 (4):299–304.  View Abstract
  27. Mitani H et al. Correlation between plasma levels of glutamate, alanine and serine with severity of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30 (6):1155–8. [PubMed] [Google Scholar]
  28. Levine J et al. Increased cerebrospinal fluid glutamine levels in depressed patients. Biol Psychiatry. 2000;47 (7):586–93.  View Abstract  
  29. Schoepp DD. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther. 2001;299 (1):12–20. View Abstract
  30. Genchi G et al. Mercury exposure and heart diseases. Int J Environ Res Public Health. 2017;14(1):74 View Full Paper
  31. Fernandes Azevedo B et al. Toxic effects of mercury on the cardiovascular and central nervous systems. J Biomed Biotechnol. 2012;2012:949048. View Full Paper
  32. Breton J et al. Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome. BMC Pharmacol Toxicol. 2013;14:62. View Full Paper

 

Glutathione References https://www.quicksilverscientific.com/glutathionereferences/

  1. Homma T et al. Application of glutathione as anti-oxidative and anti-aging drugs. Curr Drug Metab. 2015;16(7):560-71 View Abstract
  2. Ighodaroab OM et al. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid.  Alexandria Journal of Medicine 2018 (54): 287-293 View Abstract
  3. Szarka A et al. The ascorbate-glutathione-α-tocopherol triad in abiotic stress response. Int J Mol Sci. 2012;13(4):4458-83 View Full Paper
  4. Balendiran GK et al. Cell Biochem Funct. The role of glutathione in cancer. 2004 Nov-Dec;22(6):343-52. View Abstract
  5. Mari M et al. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009 Nov;11(11):2685-70 View Full Paper
  6. Perricone C et al. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. View Abstract
  7. Dröge W et al. Glutathione and immune function. Proc Nutr Soc. 2000 Nov;59(4):595-600. Review. View Abstract
  8. Bajic VP et al. Glutathione “redox homeostasis” and its relation to cardiovascular disease. Oxidative Medicine and Cellular Longevity 2019 View Abstract
  9. Pizzorno J. Glutathione! Integrative Medicine 2014 (13):1:8-12 View Full Paper
  10. Forman HJ. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. View Abstract
  11. Hodges RE et al. Modulation of metabolic detoxification pathways using foods and food-derived components: a scientific review with clinical application. J Nutr Metab. 2015;2015:760689 View Full Paper
  12. Keum YS. Regulation of Nrf2-mediated phase II detoxification and anti-oxidant genes. Biomol Ther. 2012;20(2):144-151. View Abstract
  13. Fraternale A et al. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275 View Abstract
  14. Kamide Y. Allergy. Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization. Allergy. 2011 Sep;66(9):1183-92. View Abstract
  15. Dröge W et al. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J 1994;8:1131–8. View Abstract
  16. Gambhir JK et al. Correlation between blood antioxidant levels and lipid peroxidation in rheumatoid arthritis. Clin Biochem 1997;30:351–5. View Abstract
  17. Ortona E, Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev 2008;7:579–84. View Abstract
  18. Griffiths HR. Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmun Rev 2008;7:544–9. View Abstract
  19. Burek CL, Rose NR. Autoimmune thyroiditis and ROS. Autoimmun Rev 2008;7:530–7. View Abstract
  20. Gheita TA et al.  Measurement of malondialdehyde, glutathione, and glutathione peroxidase in SLE patients. Methods Mol Biol. 2014;1134:193-9 View Abstract
  21. Kumar D et al. A link between maternal malnutrition and depletion of glutathione in the developing lens: a possible explanation for idiopathic childhood cataract? Clin Exp Optom. 2013 Nov;96(6):523-8 View Abstract
  22. Teskey G. Glutathione as a marker for human disease. Adv Clin Chem. 2018;87:141-159. View Abstract
  23. Jiang S et al. Glutathione protects against hepatic injury in a murine model of primary Sjögren’s syndrome. Bosn J Basic Med Sci. 2016 Aug 2;16(3):227-31 View Abstract
  24. Sinha R et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018 Jan;72(1):105-111 View Abstract
  25. Drisko JA. Chelation Therapy. In: Integrative Medicine (Fourth Edition) 2018: (107): 1004-1014.
  26. Lawley SD et al. Mathematical modeling of the effects of glutathione on arsenic methylation. Theor Biol Med Model. 2014 May 16;11:20. View Abstract
  27. Guildford FT et al. Deficient glutathione in the pathophysiology of mycotoxin-related illness. Toxins (Basel). 2014 Feb 10;6(2):608-23 View Full Paper
  28. Hope JH et al. A review of the diagnosis and treatment of ochratoxin a inhalational exposure associated with human illness and kidney disease including focal segmental glomerulosclerosis. J. Environ. Public Health 2012: 2012, 835059. View Abstract
  29. Damy T et al. Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities. PLoS One 2009. (4):3: e4781 vol. 4. View Abstract
  30. Biswas SK et al. Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E−/− mice. Biochemical and Biophysical Research Communications 2005 (338): 3: 1368–1373 View Abstract
  31. Shimizu H et al. Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study.  Stroke. 2004 (35):9: 2072-2077 View Abstract
  32. de la Asuncion JG et al. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. The FASEB Journal. 1996;10(2):333–338. View Abstract
  33. Rae CD et al. Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy. Anal Biochem. 2017 Jul 15;529:127-143. View Abstract
  34. Saharan S et al. The emerging role of glutathione in Alzheimer’s disease J Alzheimers Dis. 2014;40(3):519-29. View Abstract
  35. Gambhir JK et al. Correlation between blood antioxidant levels and lipid peroxidation in rheumatoid arthritis. Clin Biochem 1997;30:351–5. View Abstract
  36. Ortona E, Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev 2008;7:579–84. View Abstract
  37. Griffiths HR. Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmun Rev 2008;7:544–9. View Abstract
  38. Burek CL, Rose NR. Autoimmune thyroiditis and ROS. Autoimmun Rev 2008;7:530–7. View Abstract
  39. Gheita TA et al.  Measurement of malondialdehyde, glutathione, and glutathione peroxidase in SLE patients. Methods Mol Biol. 2014;1134:193-9 View Abstract
  40. Kumar D et al. A link between maternal malnutrition and depletion of glutathione in the developing lens: a possible explanation for idiopathic childhood cataract? Clin Exp Optom. 2013 Nov;96(6):523-8 View Abstract
  41. Teskey G. Gluathione as a marker for human disease. Adv Clin Chem. 2018;87:141-159. View Abstract
  42. Jiang S et al. Glutathione protects against hepatic injury in a murine model of primary Sjögren’s syndrome. Bosn J Basic Med Sci. 2016 Aug 2;16(3):227-31 View Abstract

 

Vitamin C w/RLA References https://www.quicksilverscientific.com/vitamincrlareferences/

  1. Bendich A et al. The antioxidant role of vitamin C. Adv Free Radic Biol Med. 1986;2:419-44 View Abstract
  2. Carr AC. Vitamin C and immune function. Nutrients. 2017 Nov 3;9(11). View Full Paper
  3. Stoyanovsky DA et al. Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid. Curr Eye Res. 1995 Mar;14(3):181-9. View Abstract
  4. Biewenga GP et al. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997 Sep;29(3):315-31. View Abstract
  5. Tibullo D et al. Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential. Inflamm Res. 2017 Nov;66(11):947-959. View Abstract
  6. Smith AR et al. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. 2004 May;11(9):1135-46. View Abstract
  7. Kagan VE et al. Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells. Biochim Biophys Acta. 2003 Mar 17;1620(1-3):72-84 View Abstract
  8. Kilic F et al. Modeling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis. Biochem Mol Biol Int. 1998 Oct;46(3):585-95 View Abstract
  9. Hagen TM et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999 Feb;13(2):411-8. View Abstract
  10. Kramer K et al. R-alpha-lipoic acid. In: Kramer K, Hoppe P, Packer L, eds. Nutraceuticals in Health and Disease Prevention. New York: Marcel Dekker, Inc.; 2001:129-164.
  11. Schleicher RL et al. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am. J. Clin. Nutr. 2009, 90, 1252–1263. View Abstract
  12. Niki E. Interaction of ascorbate and alpha-tocopheral. Ann N Y Acad Sci. 1987;498:186-99. View Abstract
  13. McCay PB. Vitamin E: Interactions with free radicals and ascorbate. Ann. Rev. Nutr.1985 5:323-340 View Abstract
  14. Dormandy TL. Free-radical oxidation and antioxidants. Lancet 1978 i: 647-650 View Abstract
  15. Salehi B. Insights on the use of α-Lipoic acid for therapeutic purposes. Biomolecules. 2019 Aug 9;9(8). View Full Paper
  16. VE Kagan et al.Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase. Biochem Pharmacol, 44 (1992), pp. 1637-1649 View Abstract
  17. Shay KP et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790:1149–1160. View Full Paper
  18. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. J Clin Biochem Nutr. 2015 Jul; 57(1): 21–26 View Abstract
  19. Goralska M et al. Alpha lipoic acid changes iron uptake and storage in lens epithelial cells. Exp. Eye Res. 2003, 76, 241–248. View Abstract
  20. Sun H et al. Alphalipoic Acid Prevents Oxidative Stress and Peripheral Neuropathy in Nab-Paclitaxel-Treated Rats through the Nrf2 Signalling Pathway. Oxid Med Cell Longev. 2019 Feb 10;2019:3142732. View Full Paper
  21. Geesin JC, Darr D et al. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 1988;90:420-424. View Abstract
  22. Ross R et al. Wound healing and collagen formation. II. Fine structure in experimental scurvy. J Cell Biol 1962;12:533-551.  View Abstract
  23. Kramer GM et al. Ascorbic acid treatment on early collagen production and wound healing in the guinea pig. J Periodontol 1979;50:189-192.  View Abstract
  24. DePhillipo NN et al. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018;6(10):2325967118804544. View Full Paper
  25. Geesin JC et al. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 1988;90:420-424. View Abstract
  26. Humbert PG, Haftek M et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol 2003;12:237-244. View Abstract
  27. Tebbe B, Wu S, et al. L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1alpha and IL-6 in cultured human keratinocytes in vitro. J Invest Dermatol 1997;108:302-306 View Abstract
  28. Carr AC et al. Vitamin C and immune function. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. View Full Paper
  29. Ran L et al. Extra dose of vitamin C based on a daily supplementation shortens the common cold: a meta-analysis of 9 randomized controlled trials. Biomed Res Int. 2018 Jul 5;2018:1837634. View Abstract
  30. Dinicola S et al. Alpha-Lipoic Acid downregulates IL-1 and IL-6 by DNA hypermethylation in SK-N-BE neuroblastoma cells. Antioxidant 2017, 6, 74. View Abstract
  31. Khalili M et al. Does lipoic acid consumption a_ect the cytokine profile in multiple sclerosis patients: A double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation 2014, 21, 291–296. View Abstract
  32. Zhang J et al. Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.
  33. Environ Toxicol Pharmacol. 2017 Apr;51:30-37. View Abstract
  34. Shi C. α-Lipoic acid protects against the cytotoxicity and oxidative stress induced by cadmium in HepG2 cells through regeneration of glutathione by glutathione reductase via Nrf2/ARE signaling pathway.Environ Toxicol Pharmacol. 2016 Jul;45:274-81. View Abstract
  35. Harada S et al. An association between idiopathic Parkinson’s disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2. Biochem Biophys Res Commun. 2001 Nov 9;288(4):887-92 View Abstract
  36. Zhang Y. Phase II Enzymes. Encyclopedia of Cancer, Ed: Manfred Schwab. Springer 2011 View Full Paper
  37. Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35 View Full Paper
  38. Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93 View Full Paper
  39. Ahn H et al. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016 Nov 23;20:36 View Full Paper
  40. Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811 View Full Paper

 

Bitters No. 9 References https://www.quicksilverscientific.com/bittersno9references/

  1. Klaassen CD and Aleksunes LM. Xenobiotic, bile acid, and cholesterol transporters: Function and regulation. Pharmacol Rev. 2010; 62(1): 1-96.
  2. Garcia M, et al. Nuclear receptor metabolism of bile acids and xenobiotics: A coordinated detoxification system with impact on health and diseases. Int J Mol Sci. 2018; 19(11): 3630.
  3. Pan X and Jeong H. Estrogen-induced cholestasis leads to repressed CYP2D6 expression in CYP2D6-humanized mice. Mol Pharmacol. 2015; 88(1): 106-112.
  4. Chan KM, et al. De novo endotoxin-induced production of antibodies against the bile salt export pump associated with bacterial infection following major hepatectomy. Biomed Res Int. 2018; 2018: 6197152.
  5. Urdaneta V and Casadesus J. Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts. Front Med (Lausanne). 2017; 4: 163.
  6. Sanchez LM, et al. Biofilm formation and detachment in gram-negative pathogens is modulated by select bile acids. PLoS One. 2016; 11(3): e0149603.
  7. Green RM, et al. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterol. 1996; 111(1): 193-198.
  8. Gonzalez-Castejon M, et al. Diverse biological activities of dandelion. Nutr Rev. 70(9): 534-547.
  9. Liu B, et al. Taraxasterol inhibits LPS-induced inflammatory response in BV2 microglia cells by activating LXRα. Front Pharmacol. 2018; 9: 278.
  10. Esatbeyoglu T, et al. Sesquiterpene lactone composition and cellular Nrf2 induction of Taraxacum officinale leaves and roots and Taraxinic Acid β-d-Glucopyranosyl Ester. J Med Food. 2017; 20(1): 71-78.
  11. Crocenzi FA, et al. Effect of silymarin on biliary bile salt secretion in the rat. Biochem Pharmacol. 2000; 59(8): 1015-1022.
  12. Surai PF. Silymarin as a natural antioxidant: An overview of the current evidence and perspectives. Antioxidants (Basel). 2015; 4(1): 204-247.
  13. Crocenzi FA, et al. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: Possible involvement of cAMP. Biochem Pharmacol. 2005; 69(7): 1113-1120.
  14. Viktorova J, et al. Antioxidant, anti-Inflammatory, and multidrug resistance modulation activity of silychristin derivatives. Antioxidants (Basel). 2019; 8(8).
  15. Federico A, et al. Silymarin/silybin and chronic liver disease: A marriage of many years. Molecules. 2017; 22(2). pii: E191.
  16. El-Lakkany NM, et al. Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis. Parasit Vectors. 2012; 5: 9.
  17. Tang X, et al. Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice. J Ethnopharmacol. 2016; 194(24): 63-71.
  18. Mirzaee F, et al. Medicinal, biological and phytochemical properties of Gentiana species. J Tradit Complement Med. 2017; 7(4): 400-408.
  19. Yamada H, et al. Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-α, iNOS and Cox-2 mRNA expression and blocks NF-κB promoter activity in murine macrophages. PLoS One. 2014; 9(11): e113834.
  20. Chodera A, et al. Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes. Acta Pol Pharm. 1991; 48(5-6): 35-37.
  21. Apati P, et al. In-vitro effect of flavonoids from Solidago canadensis extract on glutathione S-transferase. J Pharm Pharmacol. 2006; 58(2): 251-256.
  22. Toiu A, et al. Solidago graminifolia L. Salisb. (Asteraceae) as a valuable source of bioactive polyphenols: HPLC profile, in vitro antioxidant and antimicrobial potential. Molecules. 2019; 24(14): 2666.
  23. Gao Q, et al. Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. Acta Pharmacol Sin. 2018; 39(5): 787-801.
  24. Kim YK, et al. Inhibitory effect and mechanism of Arctium lappa extract on NLRP3 inflammasome activation. Evid Based Complement Alternat Med. 2018; 2018: 6346734.
  25. Alhusaini A, et al. Arctium lappa root extract prevents lead-induced liver injury by attenuating oxidative stress and inflammation and activating Akt/GSK-3β signaling. Antioxidants. 2019; 8(12): 582.
  26. Deng R, et al. The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism. J Pharmacol Exp Ther. 2007; 320(3): 1153-1162.
  27. Sarup P, et al. Pharmacology and phytochemistry of oleo-gum resin of Commiphora wightii (Guggulu). Scientifica (Cairo). 2015; 2015; 138039.
  28. Raina R, et al. Potential of Juniperus communis L as a nutraceutical in human and veterinary medicine. Heliyon. 2019; 5(8): e02376.
  29. Bais S, et al. A phytopharmacological review on a medicinal plant: Juniperus communis. Int Sch Res Notices. 2014; 2014: 634723.
  30. Marchese A, et al. Antimicrobial activity of eugenol and essential oils containing eugenol: A mechanistic viewpoint. Crit Rev Microbiol. 2017; 43(6): 668-689.
  31. Erukainure OL, et al. Orange peel extracts: Chemical characterization, antioxidant, antioxidative burst, and phytotoxic activities. J Diet Suppl. 2016; 13(5): 585-594.
  32. Geraci A, et al. Essential oil components of orange peels and antimicrobial activity. Nat Prod Res. 2017; 31(6): 653-659.
  33. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016; 20: 36.
  34. Alyautdin R, et al. Nanoscale drug delivery systems and the blood-brain barrier. Int J Nanomedicine. 2014; 9: 795-811.
  35. Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9): 1015-1035.

 

Quinton® Isotonic References https://quicksilverscientific.com/quintonisotonicreferences/

  1. Holm NG, Anderson EM. Abiotic synthesis of organic compounds under the conditions of submarine hydrothermal systems: a perspective. Planet Space Sci 1995; 43(1-2): 153-9.
  2. He HZ, Li HB et al. Determination of vitamin B1 in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 2005; 383(5): 875-9.
  3. Litchfield CD, Hood DW. Microbiological assay for organic compounds in seawater. II. Distribution of adenine, uracil, and threonine. Appl Microbiol 1966; 14(2): 145-51
  4. McCorry, LK Physiology of the autonomic nervous system. American Journal of Pharmaceutical Education. 2007: 71 (4): 78
  5. Quinton, R. L’eau De Mer, Milieu Organique: Constance Du Milieu Marin Originel, Comme Milieu Vital Des Cellules, À Travers La Série Animale. Ulan Press. 2012
  6. Yoshizawa Y, Tanojo H et al. Sea water or its components alter experimental irritant dermatitis in man, Skin Res. Technol., 2001 (7): 36–39.
  7. Kimata H, Tai H et al.  Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS), Acta Med. (Hradec Kralove, Czech Repub.), 2002 (45): 2; 83–84.
  8. Tabary O, Muselet C et al. Reduction of chemokine IL8 and RANTES expression in human bronchial epithelial cells by a sea water derived saline through inhibited nuclear factor kB activation, Biochem. Biophys. Res.Commun., 2003 (309); 2: 310–316.
  9. Miyamura M, Yoshioka S et al. Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis, Biol. Pharm. Bull., 2004; (27): 11;  1784–1787.
  10. Slapak I, Skoupá J et al Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children, Arch. Otolaryn gol. Head Neck Surg., 2008 (134); 1:  67–74.
  11. Yoshioka S, Hamada A et al. Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 2003 Nov;26(11):1552-9.
  12. Angier, N. The wonders of blood. Available at: https://www.nytimes.com/2008/10/21/science/21angi.html. Accessed June 1, 2019.
  13. Theocharis AD, Skandalis SS et al. Extracellular matrix structure. Adv Drug Deliv Rev. 2016 Feb 1;97:4-27.
  14. Pischinger, A. The Extracellular Matrix and Ground Regulation: Basis for a Holistic Biological Medicine. North Atlantic Books; 2007.
  15. Nabaa A, Clauser KR et al. The extracellular matrix: tools and insights for the “omics” era. Matrix Biol. (2016) 49; 10–24
  16. Gomez C, Deravi L. Self-assembling extracellular matrix proteins as materials for the condensation of silica nanostructures. RSC Advances 2016 (97) ra/c6ra20911d
  17. Silkin VA, Pautova LA et al. Drivers of phytoplankton blooms in the northeastern Black Sea. Mar Pollut Bull. 2019 Jan;138:274-28
  18. Litchman E, Klausmeier CA et al. The role of phytoplankton functional traits in structuring phytoplankton communities: scaling from cellular to ecosystem level. Ecol. Lett. 2007(10); 1170–1181
  19. Winder M, Cloern JE. The annual cycles of phytoplankton biomass. Phil. Trans. R. Soc. 2010; B 365: 3215–3226
  20. Lemke KH, Rosenbauer RJ et al. Peptide synthesis in early Earth hydrothermal systems. Astrobiology 2009; 9(2):141-6.
  21. Khokhlov AN, Morgunova GV et al. Pilot study of a potential geroprotector, “Quinton Marine Plasma”, in experiments on cultured cells. Biological Sciences Bulletin, 2015; (70):1; 7–11.
  22. Diaz-Llopis M, Pinazo-Duran MD, et al. A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome Clin Ophthalmol. 2019 Mar 12;13:483-490
  23. Alberola J, Coll F.  Marine therapy and its healing properties, Curr. Aging Sci., 2013; (6): 1; 63–75.
  24. Campos, M. Heart rate variability: A new way to track well-being. Harvard Health Publishing, Harvard Medical School. Available at: https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789. Accessed June 1, 2019.
  25. Presentation by Michael Kesller, DC. Quinton and the Extracellular Matrix. Available at: https://www.youtube.com/watch?v=XYFbuTQSjNo Accessed June 1, 2019.
  26. Ortells, JMS. Study of the Immunomodulatory Activity of QT solution in human PBMNc. Abstracts. 2nd European Congress of Immunology; European Journal of Immunology, Supp. 1/09
  27. Radhakrishnan G, Yamamoto M. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression. Biochem Biophys Res Commun. 2009 Sep 11;387(1):25-30.
  28. Armstrong LE, Ganio MS. Mild dehydration affects mood in healthy young women. J Nutr. 2012 Feb;142(2):382-8.
  29. Fadda R, Rapinett G. Effects of drinking supplementary water at school on cognitive performance in children. Appetite. 2012 Dec;59(3):730-7.
  30. Suhr JA, Hall J. The relation of hydration status to cognitive performance in healthy older adults.  Int J Psychophysiol. 2004 Jul;53(2):121-5.
  31. Lieberman HR. Hydration and cognition: a critical review and recommendations for future research. J Am Coll Nutr. 2007;26(5S)
  32. Paik IY, Jeong MH et al. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7.
  33. Texas Heart Institute: Trace Elements: what they do and where to get them. Available at: https://www.texasheart.org/. Accessed June 1, 2019.
  34. Dittman R. Bio-Terrain, evolutionary biology, and the practice of medicine in the early 1900’s: an intro to René Quinton’s marine plasma. Explore. 2006: (15):4
  35. Szent-Györgyi, A. Biology and pathology of water.  Perspectives in Biology and Medicine. 1971 (14);2 : 239-24f9.

 

Quinton® Hypertonic References https://www.quicksilverscientific.com/hypertonicreferences/

  1. Holm NG, Anderson EM. Abiotic synthesis of organic compounds under the conditions of submarine hydrothermal systems: a perspective. Planet Space Sci 1995; 43(1-2): 153-9.
  2. He HZ, Li HB et al. Determination of vitamin B1 in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 2005; 383(5): 875-9.
  3. Litchfield CD, Hood DW. Microbiological assay for organic compounds in seawater. II. Distribution of adenine, uracil, and threonine. Appl Microbiol 1966; 14(2): 145-51
  4. Quinton, R. L’eau De Mer, Milieu Organique: Constance Du Milieu Marin Originel, Comme Milieu Vital Des Cellules, À Travers La Série Animale. Ulan Press. 2012
  5. Yoshizawa Y, Tanojo H et al. Sea water or its components alter experimental irritant dermatitis in man, Skin Res. Technol., 2001 (7): 36–39.
  6. Kimata H, Tai H et al.  Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS), Acta Med. (Hradec Kralove, Czech Repub.), 2002 (45): 2; 83–84.
  7. Tabary O, Muselet C et al. Reduction of chemokine IL8 and RANTES expression in human bronchial epithelial cells by a sea water derived saline through inhibited nuclear factor kB activation, Biochem. Biophys. Res.Commun., 2003 (309); 2: 310–316.
  8. Miyamura M, Yoshioka S et al. Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis, Biol. Pharm. Bull., 2004; (27): 11;  1784–1787.
  9. Slapak I, Skoupá J et al Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children, Arch. Otolaryn gol. Head Neck Surg., 2008 (134); 1:  67–74.
  10. Yoshioka S, Hamada A et al. Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 2003 Nov;26(11):1552-9.
  11. Armstrong LE, Ganio MS. Mild dehydration affects mood in healthy young women. J Nutr. 2012 Feb;142(2):382-8.
  12. Fadda R, Rapinett G. Effects of drinking supplementary water at school on cognitive performance in children. Appetite. 2012 Dec;59(3):730-7.
  13. Suhr JA, Hall J. The relation of hydration status to cognitive performance in healthy older adults.  Int J Psychophysiol. 2004 Jul;53(2):121-5.
  14. Lieberman HR. Hydration and cognition: a critical review and recommendations for future research. J Am Coll Nutr. 2007;26(5S)
  15. Paik IY, Jeong MH et al. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7.
  16. Texas Heart Institute: Trace Elements: what they do and where to get them. Available at: https://www.texasheart.org/. Accessed June 1, 2019.
  17. Scotney B, Reid S. Body weight, serum sodium levels and renal function in an ultra-distance mountain run. Clin J Sport Med. 2015 Jul;25(4):341-6.
  18. Hoffman MD, Joslin J et al. Management of suspected fluid balance issues in participants of wilderness endurance events. Curr Sports Med Rep. 2017 Mar/Apr;16(2):98-102.
  19. Armstrong LE, Johnson EC et al. COUNTERVIEW: Is drinking to thirst adequate to appropriately maintain hydration status during prolonged endurance exercise? No. Wilderness Environ Med. 2016 Jun;27(2):195-8.
  20. Angier, N. The wonders of blood. Available at: https://www.nytimes.com/2008/10/21/science/21angi.html. Accessed June 1, 2019.
  21. Theocharis AD, Skandalis SS et al. Extracellular matrix structure. Adv Drug Deliv Rev. 2016 Feb 1;97:4-27.
  22. Pischinger, A. The Extracellular Matrix and Ground Regulation: Basis for a Holistic Biological Medicine. North Atlantic Books; 2007.
  23. Nabaa A, Clauser KR et al. The extracellular matrix: tools and insights for the “omics” era. Matrix Biol. (2016) 49; 10–24
  24. Gomez C, Deravi L. Self-assembling extracellular matrix proteins as materials for the condensation of silica nanostructures. RSC Advances 2016 (97) ra/c6ra20911d
  25. Silkin VA, Pautova LA et al. Drivers of phytoplankton blooms in the northeastern Black Sea. Mar Pollut Bull. 2019 Jan;138:274-28
  26. Litchman E, Klausmeier CA et al. The role of phytoplankton functional traits in structuring phytoplankton communities: scaling from cellular to ecosystem level. Ecol. Lett. 2007(10); 1170–1181
  27. Winder M, Cloern JE. The annual cycles of phytoplankton biomass. Phil. Trans. R. Soc. 2010; B 365: 3215–3226
  28. Lemke KH, Rosenbauer RJ et al. Peptide synthesis in early Earth hydrothermal systems. Astrobiology 2009; 9(2):141-6.
  29. Khokhlov AN, Morgunova GV et al. Pilot study of a potential geroprotector, “Quinton Marine Plasma”, in experiments on cultured cells. Biological Sciences Bulletin, 2015; (70):1; 7–11.
  30. Alberola J, Coll F.  Marine therapy and its healing properties, Curr. Aging Sci., 2013; (6): 1; 63–75.
  31. Campos, M. Heart rate variability: A new way to track well-being. Harvard Health Publishing, Harvard Medical School. Available at: https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789. Accessed June 1, 2019.
  32. Presentation by Michael Kesller, DC. Quinton and the Extracellular Matrix. Available at: https://www.youtube.com/watch?v=XYFbuTQSjNo Accessed June 1, 2019.
  33. Ortells, JMS. Study of the Immunomodulatory Activity of QT solution in human PBMNc. Abstracts. 2nd European Congress of Immunology; European Journal of Immunology, Supp. 1/09
  34. Radhakrishnan G, Yamamoto M. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression. Biochem Biophys Res Commun. 2009 Sep 11;387(1):25-30.
  35. Dittman R. Bio-Terrain, evolutionary biology, and the practice of medicine in the early 1900’s: an intro to René Quinton’s marine plasma. Explore. 2006: (15):4
  36. Szent-Györgyi, A. Biology and pathology of water.  Perspectives in Biology and Medicine. 1971 (14);2 : 239-24f9.

 

Pure PC References https://quicksilverscientific.com/purepcreferences/

  1. Wallace TC, et al. Choline: The under-consumed and underappreciated essential nutrient. Nutrition Today. 2018; 53(6): 240-253. View Abstract
  2. Blusztajn JK, et al. Neuroprotective actions of dietary choline. Nutrients. 2017; 9(8): 815. View Full Paper
  3. Wallace TC, et al. Usual choline intakes are associated with egg and protein food consumption in the United States. Nutrients. 2017; 9(8): 839. View Full Paper
  4. Derbyshire E. Could we be overlooking a potential choline crisis in the United Kingdom? BMJ Nutr Prev Health. 2019. View Full Paper
  5. Fischer LM, et al. Dietary choline requirements of women: effects of estrogen and genetic variation. Am J Clin Nutr. 92(5): 2010; 1113-1119. View Full Paper
  6. Cooper GM. The cell: A molecular approach. 2nd edition. Sunderland, MA: Sinauer Associates, 2000. View Book
  7. Flieger A, et al. Pathways of host cell exit by intracellular pathogens. Microb Cell. 2018; 5(12): 525-544. View Abstract
  8. Yusupov M, et al. Effect of head group and lipid tail oxidation in the cell membrane revealed through integrated simulations and experiments. Sci Rep. 2017; 7: 5761. View Abstract
  9. Ginter E and Simko V. New data on harmful effects of trans-fatty acids. Bratisl Lek Listy. 2016; 117(5): 251-253. View Abstract
  10. Velazquez R, et al. Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell. 2019; 18(6): e13037. View Abstract
  11. Whiley L, et al. Evidence of altered phosphatidylcholine metabolism in Alzheimer’s disease. Neurobiol Aging. 2014; 35(2): 271-278. View Abstract
  12. Shea TB. Choline and phosphatidylcholine may maintain cognitive performance by multiple mechanisms. Am J Clin Nutr. 2019; 110(6): 1268-1269. View Abstract
  13. Maev IG, et al. Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia. BMJ Open Gastroenterol. 2020; 7(1): e000368. View Full Paper
  14. Maev IV, et al. Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study). BMJ Open Gastroenterol. 2020; 7(1): e000341. View Full Paper
  15. Kidd P, et al. Phosphatidylcholine: A superior protectant against liver damage. Altern Med Rev. 1996; 1(4): 258-274. View Abstract
  16. Elblehi S, et al. L-α-Phosphatidylcholine attenuates mercury-induced hepato-renal damage through suppressing oxidative stress and inflammation. Environ Sci Pollut Res. 2019; 26(9) View Abstract
  17. Yamazoe Y, et al. Possible role of phosphatidylcholine and sphingomyelin on fumonisin B1-mediated toxicity. Food Saf (Tokyo). 2017; 5(3): 75-97. View Full Paper
  18. Wan S, et al. Impaired hepatic phosphatidylcholine synthesis leads to cholestasis in mice challenged with a high‐fat diet. Hepatol Commun. 2019; 3(2): 262-276. View Full Paper
  19. Zeisel SH, et al. Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat Res. 2012; 733(1-2): 34-38. View Abstract
  20. Olthof MR, et al. Choline supplemented as phosphatidylcholine decreases fasting and post methionine-loading plasma homocysteine concentrations in healthy men. Am J Clin Nutr. 2005; 82(1): 111-117. View Full Paper
  21. Lagace TA, et al. Phosphatidylcholine: Greasing the cholesterol transport machinery. Lipid Insights. 2015; 8(Suppl 1): 65-73. View Full Paper
  22. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016; 20: 36.
  23. Alyautdin R, et al. Nanoscale drug delivery systems and the blood-brain barrier. Int J Nanomedicine. 2014; 9: 795-811.
  24. Spector AA, et al. Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9): 1015-1035.
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