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EDTA References

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  2. Rahimzadeh MR, Rahimzadeh MR, Kazemi S, & Moghadamnia A. Cadmium toxicity and treatment: An update. Caspian J Intern Med. 2017; 8(3): 135-145.
  3. Witkowska D, Slowik J, & Chilicka K. Heavy metals and human health: Possible exposure pathways and the competition for protein binding sites. Molecules. 2021; 26(19): 6060.
  4. Engwa GA, Ferdinand PU, Nwalo FN, & Unachukwu MN. Mechanism and health effects of heavy metal toxicity in humans. IntechOpen; 2019.
  5. Rodriguez J & Mandalunis PM. A review of metal exposure and its effects on bone health. J Toxicol. 2018; 2018: 4854152.
  6. Bludovska M, Kotyzova D, Koutensky J, & Eybl V. The influence of alpha-lipoic acid on the toxicity of cadmium. Gen Physiol Biophys. 1999; Spec No: 28-32.
  7. Gurer H, et al. Antioxidant role of alpha-lipoic acid in lead toxicity. Free Radic Biol Med. 1999 Jul;27(1-2):75-81.
  8. Liu Y, Zhu W, Ni D, et al. Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death. J Nanobiotechnology. 2020; 18: 141.
  9. Patrick L et al. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Altern Med Rev. 2002 Dec;7(6):456-71.
  10. Packer, L.; Witt, E. H.; Tritschler, H. J., 1995: alpha-Lipoic acid as a biological antioxidant. Free Radical Biology & Medicine 19, 227–250
  11. Gonzalez-Cuevas J, Navarro-Partida J, Marquez-Aguirre AL, Bueno-Topete MR, Beas-Zarate C, & Armendariz-Borunda J. Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis. Redox Rep. 2011; 16(2): 62-70.
  12. Roussel AM et al. EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation. Altern Med Rev. 2009; 14(1): 56-61.
  13. Kagan VE, Shvedova A, Serbinova E, Khan S, Swanson C, Powell R, & Packer L. Dihydrolipoic acid–a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol. 1992; 44(8): 1637-1649.
  14. Sun H et al. Alpha lipoic acid prevents oxidative stress and peripheral neuropathy in nab-Paclitaxel-treated rats through the Nrf2 signalling pathway. Oxid Med Cell Longev. 2019 Feb 10; 2019: 3142732.
  15. Rocamonde B et al. Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury. Neuroscience. 2012; 224: 102–115.
  16. Sloth-Nielsen J et al. Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis. Am J Surg. 1991; 162(2): 122-5.
  17. Lamas GA et al. EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy. Am Heart J. 2014; 168(1): 37-44.
  18. Chen KH et al. Effect of chelation therapy on progressive diabetic nephropathy in patients with type 2 diabetes and high-normal body lead burdens. Am J Kidney Dis. 2012; 60(4): 530-8.
  19. Zanella SG. Personalization of multiple sclerosis treatments: using the chelation therapy approach. Explore (NY). 2013; 9(4): 244-8.
  20. Dinicola S et al. Alpha-Lipoic Acid2 downregulates IL-1 and IL-6 by DNA hypermethylation in SK-N-BE neuroblastoma cells. Antioxidant. 2017, 6: 74.
  21. Khalili M et al. Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: A double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation. 2014, 21, 291–296.
  22. Jonah MM, Cerny EA, & Rahman YE. Tissue distribution of EDTA encapsulated within liposomes of varying surface properties. Biochim Biophys Acta. 1975; 401(3): 336-348.
  23. Breithaupt-Grogler K, Niebch G, Schneider E, Erb K, Hermann R, Blume HH, Schug BS, & Belz GG. Dose-proportionality of oral thioctic acid–coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci. 1999; 8(1): 57-65.
  24. Kulkamp IC, Rabelo BD, Berlitz SJ, Isoppo M, Bianchin MD, Schaffazick SR, Pohlmann AR, & Guterres SS. Nanoencapsulation improves the in vitro antioxidant activity of lipoic acid. J Biomed Nanotechnol. 2011; 7(4): 598-607.


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