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H2 Elite References

  1. Ohsawa I, Ishikawa M et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007 Jun;13(6):688-94
  2. Sauer H, Wartenberg M et al. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 2001 11, 173–186
  3. Liu H, Colavitti R et al. Redox-dependent transcriptional regulation. Circ. Res. 2005 97, 967–975
  4. Bjelakovic G. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013 Sep 6;8(9):e74558
  5. Apostolova N, Victor VM. Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal. 2015 Mar 10;22(8):686-729
  6. Ohta, S. A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease. Curr. Med. Chem. 2003 10, 2485–2494
  7. Turrens JF. Mitochondrial formation of reactive oxygen species. J. Physiol. (Lond.) 2003 552, 335–344
  8. Zhai X, Chen X et al. Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression Free Radic Biol Med. 2013 Dec;65:731-741
  9. Yu J, Zhang W. Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression Toxicol Lett. 2015 Nov 4;238(3):11-9
  10. Hara F, Tatebe J et al. Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.Circ J. 2016 Aug 25;80(9):2037-46
  11. Qiang Ma. Role of Nrf2 in oxidative stress and toxicit. Annu Rev Pharmacol Toxicol. 2013; 53: 401–426.
  12. Itoh T, FujitaY et al. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651–6
  13. Itoh T, Hamada N et al. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun. 2011;411(1):143–9
  14. Hayashida K, Sano M et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 2008;373(1):30–5
  15.  Zhang Y, Sun Q et al. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol. 2011;148(1):91–5
  16. Zhang G, Gao S et al. Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats. Sci Rep. 2015;5:9858
  17. Shinbo T, Kokubo K et al. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Physiol Heart Circ Physiol. 2013;305(4):H542–50.
  18. Wood KC, Gladwin MT. The hydrogen highway to reperfusion therapy. Nat Med 2007 (13):6 673-674
  19. Ito M, Hirayama M et al. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamineinduced Parkinson’s disease in rats. Med Gas Res. 2012;2(1):15
  20. Zhang CB, Tang YC et al. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-kappaB signaling pathway. Exp Ther Med. 2015;9(6):2114–20
  21. Fukuda K, Asoh S et al. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun.2007;361(3):670–4.
  22. Shin MH, Park R et al. Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. PLoS One. 2013;8(4):e61696
  23. Yoon KS, Huang XZ et al. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biol Pharm Bull. 2011;34(11):1671–7.
  24. Ishibashi T, Sato B et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res. 2012;2(1):27
  25. Chen Q, Chen P et al. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013;40(6):857–63
  26. Xin T, Fang S. The role of hydrogen in Alzheimer’s disease. Med Gas Res. 2018 Oct-Dec; 8(4): 176–180
  27. Ichihara M, Sobue S et al., Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles. Med Gas Res, 2015. 5: 12
  28. Song G, Li M et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013 54(7), 1884–1893.
  29. Da Ponte A, Giovanelli N et al. Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness. 2018 May;58(5):612-621
  30. LeBaron TW, et al. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Can J Physiol Pharmacol. 2019; 97(9). [online].
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