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Holiday Immunity Bundle References

D3K2 References quicksilverscientific.com/d3k2references/

  1. Wilson LR et al. Vitamin D deficiency as a public health issue: using vitamin D 2 or vitamin D 3 in future fortification strategies. Proceedings of the Nutrition Society. 2017 Aug;76(3):392-9. View Abstract
  2. Holick MF. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders. 2017 Jun 1;18(2):153-65. View Abstract
  3. Parva NR et al.Prevalence of vitamin D deficiency and associated risk factors in the US population (2011-2012). Cureus. 2018 Jun 5;10(6):e2741. View Abstract
  4. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. The American journal of clinical nutrition. 2008 Aug 1;88(2):491S-9S. View Abstract
  5. Melamed ML et al. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008 Aug 11;168(15):1629-37. View Abstract
  6. Tripkovic L et al Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95(6):1357–1364. View Full Paper
  7. Cranney A et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess . 2007 Aug;(158):1–235. View Abstract 
  8. White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008 Sep;76(9):3837-43. View Full Paper
  9. Prietl B et al. Vitamin D and immune function. Nutrients. 2013 Jul 5;5(7):2502–21. View Abstract
  10. Vanherwegen A-S et al. Regulation of immune function by vitamin D and its uses in immunity. Endocrinol Metab Clin North Am. 2017 Dec;46(4):1061–94. View Abstract
  11. Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006 Dec 20;296(23):2832–8. View Absract
  12. Calvo MS, Whiting SJ, Barton CN. Vitamin D intake: a global perspective of current status. J Nutr. 2005;135(2):310-316. [Article]
  13. Zhang R, Naughton DP. Vitamin D in health and disease: current perspectives. Nutr J. 2010;9:65. [Article]
  14. Zdrenghea MT, et al. Vitamin D modulation of innate immune responses to respiratory viral infections. Rev Med Virol [Internet]. 2017 Jan;27(1). View Abstract
  15. Xiao L, et al. Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials. Br J Nutr. 2015 Aug 27:1-9. View Abstract
  16. Martineau AR et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. View Absract
  17. Yildiz I, Unuvar E, Zeybek U, et al. The role of vitamin D in children with recurrent tonsillopharyngitis.  Ital J Pediatr. 2012 Jun 8;38:25.  View Full Paper
  18. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009 Feb 23;169(4):384-90. View Full Paper
  19. Quraishi SA, Bittner EA, Christopher KB, Camargo CA Jr. Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. PLoS One. 2013 Nov 15;8(11):e81120. View Full Paper
  20. Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013 Feb;202:100-7. View Full Paper
  21. Anglin RES et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013 Feb;202:100–7. [Article]
  22. Shaffer JA et al. Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials. Psychosom Med. 2014 Apr;76(3):190–6. View Abstract
  23. Penckofer S et al. Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes. J Diabetes Res. 2017 Sep 7;2017:8232863. View Abstract
  24. Gloth FM 3rd, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging. 1999;3(1):5-7. View Abstract
  25. Landel V et al. Vitamin D, cognition and Alzheimer’s Disease: the therapeutic benefit is in the D-Tails. J. Alzheimers Dis. 2016;53(2):419–444. View Full Paper
  26. Goodwill AM. A systematic review and meta-analysis of the effect of low vitamin D on cognition. J Am Geriatr Soc. 2017 Oct;65(10):2161-2168. View Abstract
  27. Morello M. Vitamin D improves neurogenesis and cognition in a mouse model of Alzheimer’s disease. Mol Neurobiol. 2018 Aug;55(8):6463-6479. View Full Paper
  28. Gangwar AK et al. Role of Vitamin-D in the prevention and treatment of Alzheimer’s disease. Indian J Physiol Pharmacol. 2015 Jan;59(1):94–9. View Abstract
  29. Yin Yet al. Nutrient biomarkers and vascular risk factors in subtypes of mild cognitive impairment: a cross-sectional study. J Nutr Health Aging. 2015 Jan;19(1):39–47. View Abstract
  30. Wood JM et al. Vitamin D and neurocognitive disorder due to Alzheimer’s disease: A review of the literature. Ann Clin Psychiatry. 2015 Aug;27(3):206–12. View Abstract
  31. Mheid IA et al. Vitamin D and cardiovascular disease. State-of-the-Art-Review. Journal of the American College of Cardiology 2017 (70):1: 89-100 View Abstract
  32. Rai V et al. Role of vitamin D in cardiovascular diseases.Endocrinol Metab Clin North Am. 2017 Dec;46(4):1039-1059 View Abstract
  33. Brinkley DM et al. Vitamin D and heart failure. Curr Heart Fail Rep. 2017 Oct;14(5):410-420. View Abstract
  34. Khan A et al. Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3 – clinical implications for cardiovascular diseases.Int J Nanomedicine. 2018 Jan 19;13:455-466. View Abstract
  35. Mathyssen C et al. Vitamin D supplementation in respiratory diseases: evidence from randomized controlled trials. Pol Arch Intern Med. 2017 Nov 30;127(11):775–84. View Abstract
  36. Burkes RM et al. Associations among 25-Hydroxyvitamin D levels, lung function, and exacerbation outcomes in COPD: An analysis of the SPIROMICS cohort. Chest. 2020 Jan 17. View Abstract
  37. Sluyter JD et al. Effect of monthly, high-dose, long-term vitamin D on lung function: a randomized controlled trial. Nutrients [Internet]. 2017 Dec 13;9(12). View Abstract
  38. Bügel S. Vitamin K and bone health in adult humans. Vitam Horm. 2008;78:393-416. View Abstract
  39. Iwamoto I, Kosha S, Noguchi S-i. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas. 1999;31(2):161-164. [Article]
  40. Onodera K, Takahashi A, Sakurada S et al. Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats. Life Sciences. 2002;70(13):1533-1542. [Article]
  41. Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35 View Full Paper
  42. Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93 View Full Paper
  43. Ahn H et al. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016 Nov 23;20:36 View Full Paper
  44. Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811 View Full Paper

Vitamin C+ Elderberry quicksilverscientific.com/vitamincelderberryreferences/

  1. Imanpour S, et al. Factors associated with antibiotic prescriptions for the viral origin diseases in office-based practices, 2006–2012. JRSM Open. 2017; 8(8): 2054270417717668.
  2. De Clercq E, Li G. Approved antiviral drugs over the past 50 years. Clin Microbiol Rev. 2016; 29(3): 695-747.
  3. Sanjuan R and Domingo-Calap P. Mechanisms of viral mutation. Cell Mol Life Sci. 2016; 73(23): 4433-4448.
  4. Rikin S, et al. Assessment of temporally-related acute respiratory illness following influenza vaccination. Vaccine. 2018; 36(15): 1958-1964.
  5. Carr AC and Maggini S. Vitamin C and immune function. Nutrients. 2017; 9(11).
  6. Washko PW, et al. Ascorbic acid recycling in human neutrophils. J Biol Chem. 1993; 268(21): 15531-15535.
  7. Reshi ML, et al. RNA viruses: ROS-mediated cell death. Int J Cell Biol. 2014; 2014: 467452.
  8. Ware HH, et al. Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections. PLoS One. 2019; 14(2): e0208216.
  9. Lin X, et al. The influenza virus H5N1 infection can induce ROS production for viral replication and host cell death in A549 cells modulated by human Cu/Zn superoxide dismutase (SOD1) overexpression. Viruses. 2016; 8(1): 13.
  10. Pehlivan FE. Vitamin C: An antioxidant agent. Intech Open. 2017; DOI: 10.5772/intechopen.69660.
  11. Lenton KJ, et al. Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am J Clin Nutr. 2003; 77(1): 189-195.
  12. Diotallevi M, et al. Glutathione fine-tunes the innate immune response toward antiviral pathways in a macrophage cell line independently of its antioxidant properties. Front Immunol. 2017; 8: 1239.
  13. Atherton JG, et al. The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus. Arch Virol. 1978; 56: 195-199.
  14. Davelaar FG and Bos J. Ascorbic acid and infectious bronchitis infections in broilers. Avian Pathol. 1992; 21(4): 581-589.
  15. Hemila H and Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999; 3(9): 756-761.
  16. Silva da Costa L, et al. RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux. Cell Death & Dis. 2019; 10: 346.
  17. Tisoncik JR, et al. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012; 76(1): 16-32.
  18. Sang X, et al. Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS. Inflammasome. 2016; 2(1): [online].
  19. Davis JL, et al. Liposomal-encapsulated ascorbic acid: Influence on vitamin C bioavailability and capacity to protect against ischemia-reperfusion injury. Nutr Metab Insights. 2016; 9: 25-30.
  20. Kim Y, et al. Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon-α/β at the initial stage of Influenza A virus (H3N2) infection. Immune Netw. 2013; 13(2): 70-74.
  21. Mousavi S, et al. Immunomodulatory and antimicrobial effects of vitamin C. Eur J Microbiol Immunol (Bp). 2019; 9(3): 73-79.
  22. Torabian G, et al. Anti-influenza activity of elderberry (Sambucus nigra). J Funct Foods. 2019; 54: 353-360.
  23. Ho GTT, et al. Elderberry and elderflower extracts, phenolic compounds, and metabolites and their effect on complement, RAW 264.7 macrophages and dendritic cells. Int J Mol Sci. 2017; 18(3): [online].
  24. Simonyi A, et al. Inhibition of microglial activation by elderberry extracts and its phenolic components. Life Sci. 2015; 128: 30-38.
  25. Lavefve L, et al. Berry polyphenols metabolism and impact on human gut microbiota and health. Food & Funct. 2020: [online].
  26. Hawkins J, et al. Black elderberry (Sambucus Nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019; 42: 361-365.
  27. Tiralongo E, et al. Elderberry supplementation reduces cold duration and symptoms in air-travelers: a randomized, double-blind placebo-controlled clinical trial. 2016; 8(182): [online].
  28. Khomich OA, et al. Redox biology of respiratory viral infections. Viruses. 2018; 10(8): 392.
  29. Strugala P, et al. A comprehensive study on the biological activity of elderberry extract and cyanidin 3-O-glucoside and their interactions with membranes and human serum albumin. Molecules. 2018; 23(10): 2566.
  30. Serbinova E, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. 1991; 10(5): 263-275.
  31. Ren Z, et al. Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr. 2010; 140(7): 1335-1341.
  32. Lee GY and Han SN. The role of vitamin E in immunity. Nutrients. 2018; 10(11): 1614.
  33. Pour PM, et al. The signaling pathways, and therapeutic targets of antiviral agents: Focusing on the antiviral approaches and clinical perspectives of anthocyanins in the management of viral diseases. Front Pharmacol. 2019; 10: 1207.
  34. Arroyo-Maya IJ, et al. Biopolymer nanoparticles as potential delivery systems for anthocyanins: Fabrication and properties. Food Res Int. 2015; 69: 1-8.
  35. Chen BH, et al. Nanoemulsion and nanoliposome based strategies for improving anthocyanin stability and bioavailability. Nutrients. 2019; 11(5): 1052.
  36. Bryla A, et al. Encapsulation of elderberry extract into phospholipid nanoparticles. J Food Engineer. 2015; 167(B): 189-195.
  37. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016; 20: 36.
  38. Alyautdin R, et al. Nanoscale drug delivery systems and the blood-brain barrier. Int J Nanomedicine. 2014; 9: 795-811.
  39. Spector AA, et al. Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9): 1015-1035.

QuintEssential 0.9 quicksilverscientific.com/quintonisotonicreferences/

  1. Holm NG, Anderson EM. Abiotic synthesis of organic compounds under the conditions of submarine hydrothermal systems: a perspective. Planet Space Sci 1995; 43(1-2): 153-9.
  2. He HZ, Li HB et al. Determination of vitamin B1 in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 2005; 383(5): 875-9.
  3. Litchfield CD, Hood DW. Microbiological assay for organic compounds in seawater. II. Distribution of adenine, uracil, and threonine. Appl Microbiol 1966; 14(2): 145-51
  4. McCorry, LK Physiology of the autonomic nervous system. American Journal of Pharmaceutical Education. 2007: 71 (4): 78
  5. Quinton, R. L’eau De Mer, Milieu Organique: Constance Du Milieu Marin Originel, Comme Milieu Vital Des Cellules, À Travers La Série Animale. Ulan Press. 2012
  6. Yoshizawa Y, Tanojo H et al. Sea water or its components alter experimental irritant dermatitis in man, Skin Res. Technol., 2001 (7): 36–39.
  7. Kimata H, Tai H et al.  Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS), Acta Med. (Hradec Kralove, Czech Repub.), 2002 (45): 2; 83–84.
  8. Tabary O, Muselet C et al. Reduction of chemokine IL8 and RANTES expression in human bronchial epithelial cells by a sea water derived saline through inhibited nuclear factor kB activation, Biochem. Biophys. Res.Commun., 2003 (309); 2: 310–316.
  9. Miyamura M, Yoshioka S et al. Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis, Biol. Pharm. Bull., 2004; (27): 11;  1784–1787.
  10. Slapak I, Skoupá J et al Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children, Arch. Otolaryn gol. Head Neck Surg., 2008 (134); 1:  67–74.
  11. Yoshioka S, Hamada A et al. Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 2003 Nov;26(11):1552-9.
  12. Angier, N. The wonders of blood. Available at: https://www.nytimes.com/2008/10/21/science/21angi.html. Accessed June 1, 2019.
  13. Theocharis AD, Skandalis SS et al. Extracellular matrix structure. Adv Drug Deliv Rev. 2016 Feb 1;97:4-27.
  14. Pischinger, A. The Extracellular Matrix and Ground Regulation: Basis for a Holistic Biological Medicine. North Atlantic Books; 2007.
  15. Nabaa A, Clauser KR et al. The extracellular matrix: tools and insights for the “omics” era. Matrix Biol. (2016) 49; 10–24
  16. Gomez C, Deravi L. Self-assembling extracellular matrix proteins as materials for the condensation of silica nanostructures. RSC Advances 2016 (97) ra/c6ra20911d
  17. Silkin VA, Pautova LA et al. Drivers of phytoplankton blooms in the northeastern Black Sea. Mar Pollut Bull. 2019 Jan;138:274-28
  18. Litchman E, Klausmeier CA et al. The role of phytoplankton functional traits in structuring phytoplankton communities: scaling from cellular to ecosystem level. Ecol. Lett. 2007(10); 1170–1181
  19. Winder M, Cloern JE. The annual cycles of phytoplankton biomass. Phil. Trans. R. Soc. 2010; B 365: 3215–3226
  20. Lemke KH, Rosenbauer RJ et al. Peptide synthesis in early Earth hydrothermal systems. Astrobiology 2009; 9(2):141-6.
  21. Khokhlov AN, Morgunova GV et al. Pilot study of a potential geroprotector, “Quinton Marine Plasma”, in experiments on cultured cells. Biological Sciences Bulletin, 2015; (70):1; 7–11.
  22. Diaz-Llopis M, Pinazo-Duran MD, et al. A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome Clin Ophthalmol. 2019 Mar 12;13:483-490
  23. Alberola J, Coll F.  Marine therapy and its healing properties, Curr. Aging Sci., 2013; (6): 1; 63–75.
  24. Campos, M. Heart rate variability: A new way to track well-being. Harvard Health Publishing, Harvard Medical School. Available at: https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789. Accessed June 1, 2019.
  25. Presentation by Michael Kesller, DC. Quinton and the Extracellular Matrix. Available at: https://www.youtube.com/watch?v=XYFbuTQSjNo Accessed June 1, 2019.
  26. Ortells, JMS. Study of the Immunomodulatory Activity of QT solution in human PBMNc. Abstracts. 2nd European Congress of Immunology; European Journal of Immunology, Supp. 1/09
  27. Radhakrishnan G, Yamamoto M. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression. Biochem Biophys Res Commun. 2009 Sep 11;387(1):25-30.
  28. Armstrong LE, Ganio MS. Mild dehydration affects mood in healthy young women. J Nutr. 2012 Feb;142(2):382-8.
  29. Fadda R, Rapinett G. Effects of drinking supplementary water at school on cognitive performance in children. Appetite. 2012 Dec;59(3):730-7.
  30. Suhr JA, Hall J. The relation of hydration status to cognitive performance in healthy older adults.  Int J Psychophysiol. 2004 Jul;53(2):121-5.
  31. Lieberman HR. Hydration and cognition: a critical review and recommendations for future research. J Am Coll Nutr. 2007;26(5S)
  32. Paik IY, Jeong MH et al. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7.
  33. Texas Heart Institute: Trace Elements: what they do and where to get them. Available at: https://www.texasheart.org/. Accessed June 1, 2019.
  34. Dittman R. Bio-Terrain, evolutionary biology, and the practice of medicine in the early 1900’s: an intro to René Quinton’s marine plasma. Explore. 2006: (15):4
  35. Szent-Györgyi, A. Biology and pathology of water.  Perspectives in Biology and Medicine. 1971 (14);2 : 239-24f9.
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