The Healing Potential of a Universal GI Binder Blend - News and Education Blog
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The Healing Potential of a Universal GI Binder Blend

The familiar homily, “A stitch in time saves nine” truly applies to gastrointestinal (GI) binders. GI binders latch on to noxious chemicals and toxins, rendering them inactive and allowing us to excrete them safely. In the simple act of binding toxins, they are a powerful aid to our own detoxification system, not only at the level of the gut, but also in the liver and kidneys, and at a cellular level inside all our cells.

Although we know the importance of gut health, many are unaware of the mechanisms by which gut health impacts detoxification. Toxins, including heavy metals and pesticides or herbicides, are irritating to the mucosal lining of the GI tract and lead to inflammation.1,2,3,4 An inflamed gut lining soon becomes “leaky”—letting bacterial toxins seep into the bloodstream, where they strongly stimulate our body’s inflammatory response.5,6 Bacterial endotoxins, and the cascade of inflammatory cytokines they trigger, can also damage the liver and gallbladder, further impairing detoxification.7,8 Exposure to endotoxin also has an effect on detoxification directly, downregulating critical Phase III transporters, the pumps that serve to transport toxins out of our cells and body – causing us to become even more toxic.9,10 Endotoxin and the associated inflammation additionally leads to glutathione depletion, which contributes to even more damage because we are no longer are able to transport toxins out of the cells or protect them from the increased oxidative stress and damage.11,12 What a vicious cycle!

But GI binders can offset all that. Tried and true natural binders such as activated charcoal and clay have been used for thousands of years as remedies for stomach upset, minor food poisoning, and to promote intestinal cleansing.13 Binders are truly a powerful tool in our healing armamentarium, for they can arrest this spiral of inflammation and impaired detoxification before it begins. They are a fundamental first step to repairing our detoxification channels - supporting our ability to excrete toxins and thus restoring our own detoxification systems.

Not all binders are created equal. There is no universal toxin binder that has an equal affinity for all toxins—bacterial, heavy metal, mold and more. We could line up a pharmacopeia of binders on our kitchen countertop, but which would we choose, and when? A comprehensive blend of GI binders, carefully selected to provide effective coverage for a range of common toxins and toxic heavy metals, is a simple and effective approach. Because binders, such as charcoal, on their own can contribute to constipation, it can be useful to enhance them with additional elements that help bulk up the stool, soothe the intestinal lining, and support the balance of healthy gastrointestinal flora for normal motility and function. Here follows a short list of gentle but potent binders that together offer unparalleled synergy and potency.

*Activated Charcoal. The use of activated charcoal to bind toxins dates back to the 1800s. In 1831, a French physician took a lethal dose of the poison strychnine, standing before the French Academy of Medicine, and suffered no ill effects because he also consumed charcoal at the same time.14 Since that time, the adsorbing ability and clinical benefits of charcoal have been well described.15 Activated charcoal effectively adsorbs pesticides and herbicides,16 mold toxins,17 endotoxin,18 and more.

In addition to its adsorptive properties, charcoal has demonstrated benefits during infections where an individual’s strong inflammatory response to a pathogen is potentially damaging. Charcoal has been shown to adsorb and remove the inflammatory molecules associated with the immune response (such as interleukins and tumor necrosis factor) that are primary contributors to cellular damage.19 Research suggests it may be useful as an adjunctive therapy for this reason in settings of infection.20 

*Bentonite Clay. Bentonite clay is also known as Montmorillonite clay, for the region in France where it was first discovered.21 The use of healing clays dates back to ancient civilizations in the Andes, who carried balls of clay for consuming at will, to protect against poisons and toxins.22 Bentonite clay easily absorbs liquids and their toxins as well, expanding in volume. Bentonite clay is particularly good at absorbing aflatoxin, a mold toxin often found in peanuts and on some grains,23 pesticides and herbicides,24 and cyanotoxins, found in lakes polluted by harmful algal blooms.25 Bentonite clay also has intrinsic broad-spectrum antibacterial properties and has a healing effect on the gastrointestinal lining.26

*Chitosan. Derived from shellfish, chitosan is the result of enzymatic treatment of chitin, a component of the shell. Chitin has been used since ancient times, and these instructions can be found in a book of medicine dating back to the Ming Dynasty: “Break a crab shell, grind it, make a ball out of it and eat it to treat anything that swells or grows.”27 Chitosan is composed of long-chain sugars called oligosaccharides and has a prebiotic effect, promoting the growth of friendly Bifidobacterium and Lactobacillus gastrointestinal flora.28 Chitosan can bind to the bile salts that emulsify fat, and thus serves to reduce fat absorption.29 More importantly where detoxification is concerned, it also binds and removes the conjugated toxins present in bile salts. Chitosan binds to many metals as well as polychlorinated biphenyls (PCBs), phthalates, and bisphenol A (BPA), compounds with many known adverse impacts on health that we are widely exposed to in the environment.30,31,32,33 Like bentonite clay, chitosan may be a helpful approach to bacterial infection as well, inhibiting the growth of Staphylococcus aureus in one study.34 Chitosan has been shown to have some protective effects against mercury-induced genotoxicity.35

*IMD. The Intestinal Metals Detox (IMD) is a proprietary product that consists of highly purified silica with covalently attached thiolic metal-binding groups. This proprietary thiol-functionalized silica delivers insoluble thiol groups to bind and eliminate mercury and other heavy metals accumulated in the intestines, also directly quenching free-radicals. Both the silica base and the binding agents out-compete other compounds for metals in the intestines. IMD does not enter the bloodstream, and thus it will not lead to redistribution or surges of mobilized metals that can potentially lead to kidney/liver overload.

The use of thiolated resins dates back to the 1970s when they were used to address methylmercury (MeHg) poisoning in Iraq, and were found to significantly reduce the half-life of MeHg from 61 to 20 days, performing even better than penicillamine, a medical metal chelating agent.36,37 IMD intercepts MeHg and other metals trapped in enterohepatic circulation, binding them and escorting them out of the intestines.38 By doing so, this allows organ and tissue bound mercury to safely drain into the blood at a natural rate.

*Aloe and Acacia Gum. Both aloe and acacia gum are soothing and healing to the gastrointestinal tract, and can offset the constipation that can sometimes occur with the use of GI binders. Acacia gum contains water-soluble dietary fibers that have a prebiotic effect, stimulating the growth of friendly Bifidobacterium and Lactobacillus bacteria in the gut, as well as improving levels of butyrate, a short-chain fatty acid with anti-inflammatory effects that also helps to reduce intestinal permeability.39,40 Bifidobacteria support the reduction of the damaging endotoxin, and normalize gut function, reducing irritation and inflammation.41,42 Acacia gum also has antioxidant and free-radical scavenging activity.43 As a prebiotic fiber it is well tolerated at high doses with significantly less symptoms than other prebiotics such as fructooligosaccharide (FOS).

Aloe vera is best known for the soothing effect it has, commonly being found around many households and used topically for mild burns to the skin. The topical soothing properties are not only experienced by the skin, and it has a long history of use for a variety of gastrointestinal conditions associated with inflammation: peptic ulcer disease, gastritis, and inflammatory bowel disease.44,45,46 Aloe vera gel has been shown to have immunomodulatory, antioxidant, and anti-inflammatory effects, which may support healing in a variety of settings.47,48,49



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2 Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of environmental pollutants? Biofilms & Microbiomes. 2016 May 4.

3 Awad WA, Hess C, Hess M. Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens. Toxins (Basel). 2017 Feb 10;9(2).

4 Batah J, Kobeissy H, Bui Pham PT et al. Clostridium difficile flagella induce a pro-inflammatory response in intestinal epithelium of mice in cooperation with toxins. Sci Rep. 2017 Jun 12;7(1):3256

5 Ahmad R, Sorrell MF, Batra SK, et al. Gut permeability and mucosal inflammation: bad, good or context dependent. Mucosal Immunol. 2017 Mar;10(2):307-317

6Li Y, Wu Y, Yao X et al. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4)

7 Whiting JF, Green RM, Rosenbluth AB et al. Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis.Hepatology. 1995 Oct;22(4 Pt 1):1273-8.

8 Kalitsky-Szirtes J, Shayeganpour A, Brocks DR et al. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats., Drug Metab Dispos. 2004 Jan;32(1):20-7.

9 Tang W, Yi C, Kalitsky J, Piquette-Miller M. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats. Mol Cell Biol Res Commun. 2000 Aug;4(2):90-7.

10 Kalitsky-Szirtes J, Shayeganpour A, Brocks DR, Piquette-Miller M. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metab Dispos. 2004 Jan;32(1):20-7.

11 Nadeem A, Siddiqui N, Alharbi NO et al. Acute glutathione depletion leads to enhancement of airway reactivity and inflammation via p38MAPK-iNOS pathway in allergic mice. Int Immunopharmacol. 2014 Sep;22(1):222-9.

12 Carbonell LF, Nadal JA, Llanos MC, et al. Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model. Critical care medicine. 2000 Jun 1;28(6):2002-6.

13 St George, G. (2015) How Clays Work:: Science and Applications of Clays and Clay-Like Minerals in Health and Beauty, Pure Nature Cures.

14 Secheyron D: Le carbon animal ou veg6tal; antidote g6n6ral populaire. Congres Francais de medecine Comptes Rendus, 16th. 1902; 2:373-386

15 Holt LE, Holz DH: The black bottle. J Pediatr 1963; 63:306-314

16 Zhelezova A, Cederlund H, Stenström J. Effect of Biochar Amendment and Ageing on Adsorption and Degradation of Two Herbicides.Water Air Soil Pollut. 2017;228(6):216.

17 Monge Mdel P, Magnoli AP, Bergesio MV et al. Activated carbons as potentially useful non-nutritive additives to prevent the effect of fumonisin B1 on sodium bentonite activity against chronic aflatoxicosis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jun;33(6):1043-5.

18 Nolan JP, McDevitt JJ, Goldmann GS, Bishop C. Endotoxin binding by charged and uncharged resins. Proc Soc Exp Biol Med. 1975 Jul;149(3):766-70.

19 Howell CASandeman SRPhillips GJ et al. Nanoporous activated carbon beads and monolithic columns as effective hemoadsorbents for inflammatory cytokines. Int J Artif Organs. 2013 Oct 3;36(9):624-32.

20 de Souza JB, Okomo U, Alexander ND et al. Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate. PLoS One. 2010 Apr 15;5(4):e9867.


22 Price, W. Nutrition and Physical Degeneration 8th Edition. (2009) Price-Pottenger Nutrition Foundation.

23 Nones J, Nones J, Poli A et al. Organophilic treatments of bentonite increase the adsorption of aflatoxin B1 and protect stem cells against cellular damage. Colloids Surf B Biointerfaces. 2016 Sep 1;145:555-61.

24 Lagaly G. Pesticide–clay interactions and formulations. Applied Clay Science. 2001 May 31;18(5):205-9.

25 Sukenik A, Viner-Mozzini Y, Tavassi M, et al. Removal of cyanobacteria and cyanotoxins from lake water by composites of bentonite with micelles of the cation octadecyltrimethyl ammonium (ODTMA). Water Res. 2017 Sep 1;120:165-173

26 Haydel SE, Remeni CM, Willias LB. Broad-spectrum in vitro antibacterial activities of clay minerals againstantibiotic-susceptible and antibiotic-resistant bacterial pathogens. J Antimicrob Chemother 2008 Feb; 61(2): 353–361.

27 Matsunaga, A, M.D., Ph.DChitosan, The Ultimate Health Builder. (1998) Vintage Press,

28 Lee HW, Park YS, Jung JS et al. Chitosan oligosaccharides, dp 2-8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp. Anaerobe. 2002 Dec;8(6):319-24.

29 Gallaher CM, Munion J, Hesslink R Jr, et al. Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats. J Nutr. 2000 Nov;130(11):2753-9.

30 Gerente C, Lee VK, Cloirec PL, McKay G. Application of chitosan for the removal of metals from wastewaters by adsorption—mechanisms and models review. Crit Rev Enviro Sci Tech. 2007 Jan 1;37(1):41-127.

31 Lind L, Lind PM. Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease? (Review). J Intern Med 2012; 271: 537–553.

32 Dehghani MH, Ghadermazi M, Bhatnagar A, et al. Adsorptive removal of endocrine disrupting bisphenol A from aqueous solution using chitosan. J Enviro Chem Eng 2016 Sep 30;4(3):2647-55.

33 Salim CJ, Liu H, Kennedy JF. Comparative study of the adsorption on chitosan beads of phthalate esters and their degradation products. Carbo Polymers. 2010 Jul 7;81(3):640-4.

34 Moon JS, Kim HK, Koo HC et al. The antibacterial and immunostimulative effect of chitosan-oligosaccharides against infection by Staphylococcus aureus isolated from bovine mastitis. Appl Microbiol Biotechnol. 2007 Jul;75(5):989-98.

35 Yoon HJ, Park HS, Bom HS et al. Chitosan oligosaccharide inhibits 203HgCl2-induced genotoxicity in mice: micronuclei occurrence and chromosomal aberration. Arch Pharm Res. 2005 Sep;28(9):1079-85. Erratum in: Arch Pharm Res. 2005 Oct;28(10):1203.

36 Clarkson TW, Magos L, Cox C, et al. Tests of efficacy of antidotes for removal of methylmercury in human poisoning during the Iraq outbreak. J Pharmacol Exp Ther. 1981 Jul;218(1):74-83.

37 Rafati-Rahimzadeh M, Rafati-Rahimzadeh M, Kazemi S, Moghadamnia AA. Current approaches of the management of mercury poisoning: need of the hour. Daru. 2014 Jun 2;22:46.

38 Clarkson TW, Small H, Norseth T. Excretion and Absorption of Methyl Mercury After Polythiol Resin Treatment. Archives of Environmental Health: An International Journal. 1973 Apr 1;26(4):173-6.

39 Meance SE. Acacia gum (Fibregum™), a very well tolerated specific natural prebiotic having a wide range of food applications-Part 1. Agro Food Industry Hi Tech. 2004 Jan 1;15(1):24-9.

40 Canani RB, Costanzo MD, Leone L, et al. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011 Mar 28;17(12):1519-28.

41 Griffiths EA, Duffy LC, Schanbacher FL, et al. In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice. Dig Dis Sci. 2004 Apr;49(4):579-89.

42 Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013 Apr 22;5(4):1417-35.

43 Pal R, Hooda MS, Antioxidant potential and free radical scavenging activity by pod extracts of acacia senegal wiild. IJPCBS 2012, 2(4), 500-506.

44 Rajeswari R, Umadevi M, Rahale CS, et al. Aloe vera: the miracle plant its medicinal and traditional uses in India. J Pharmacog Phytochem. 2012 Nov 1;1(4).

45 Borra SK, Lagisetty RK, Mallela GR. Anti-ulcer effect of Aloe vera in non-steroidal anti-inflammatory drug induced peptic ulcers in rats. African J Pharm Pharmacol. 2011 Oct 29;5(16):1867-71.

46 Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther. 2004 Mar 1;19(5):521-7.

47 Im SA, Lee YR, Lee YH, et al. In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel. Arch Pharm Res. 2010 Mar;33(3):451-6.

48 Davis RH, Donato JJ, Hartman GM, Haas RC. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc. 1994 Feb;84(2):77-81.

49 Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep. 2005 Jan-Feb;57(1):90-6.

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