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Methyl B12 References

  1. O’Leary F. Vitamin B12 in health and disease Nutrients. 2010 Mar;2(3):299-316. View Full Paper
  2. James JS, Melnyk S et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1): 425–430 View Full Paper
  3. Horvath S et al. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018 Jun;19(6):371-384. View Abstract
  4. Lorenzl S et al. Clinically and MRI documented funicular myelosis in a patient with metabolical Vitamin B12 deficiency but normal Vitamin B12 serum level.  Neurol. 2003;250:1010–1011.  View Abstract
  5. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009 Feb; 89(2):693S-6S. View Abstract
  6. Li S J et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig. 2016 Sep;7(5):777-85. View Full Paper
  7. Korem M et al. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences 2005: 233: 93 – 97View Abstract
  8. Zhang Y et al. Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia. PLoS One. 2016 Jan 22;11(1):e0146797. View Full Paper
  9. Kwok T et al. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr. 2011 Jun;30(3):297-302. View Abstract
  10. Kasuya M. The effect of methylcobalamin on the toxicity of methylmercury and mercuric chloride on nervous tissue in culture. Toxicol Lett. 1980 Nov;7(1):87-93. View Abstract
  11. Aktaş Ş. Vitamin B12 and vitamin D levels in patients with autoimmune hypothyroidism and their correlation with the antithyroid peroxidase antibodies. Med Princ Pract. 2019 Nov 29. View Abstract
  12. Elmadfa I et al. The role of the status of selected micronutrients in shaping the immune function. Endocr Metab Immune Disord Drug Targets. 2019;19(8):1100-1115. View Abstract
  13. Smith AD et al. Vitamin B12. In: Advances in Food and Nutrition Research, Volume 83. Elsevier. 2018
  14. Moore LD et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38.View Full Paper
  15. Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol. 2008;15(2):72–75. View Full Paper
  16. Shames DS, Minna JD et al. DNA methylation in health, disease, and cancer. Curr Mol Med 7: 85-102 View Full Paper
  17. Borowa-Mazgaj B et al. Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicol Sci. 2019 May 14. pii: kfz110 View Full Paper
  18. Ligthart S et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255 View Full Paper
  19. Murphy TM et al. Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes Psychiatr Genet. 2015 Apr;25(2):71-8. View Abstract
  20. Brosnan JT. The sulfur-containing amino acids: an overview J Nutr. 2006 Jun;136(6 Suppl):1636S-1640S. View Abstract
  21. Ma Y et al. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases. BMC Cardiovasc Disord. 2017;17(1):37.View Full Paper
  22. Hoffman M. Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. Med Hypotheses. 2011;77:1088–93. View Abstract
  23. McCaddon A et al. L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer’s disease-related cognitive decline. CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5; discussion 6. Review. View Abstract
  24. Antoniades C et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J. 2009;30:6–15. View Abstract
  25. Watanabe T. J Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy.Neurol Sci. 1994 Apr;122(2):140-3. View Abstract
  26. Wu F et al. Vitamin B12 enhances nerve repair and improves functional recovery after traumatic brain injury by inhibiting ER stress-induced neuron injury. Front Pharmacol. 2019;10:406. View Full Paper
  27. Zhang M et al. Methylcobalamin: A potential vitamin of pain killer. Neural Plast. 2013; 2013: 42465 View Full Paper
  28. Gröber U et al. Neuroenhancement with vitamin B12-underestimated neurological significance. Nutrients. 2013;5(12):5031–5045. View Full Paper
  29. McCaddon A et al. L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer’s disease-related cognitive decline. CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5; discussion 6. View Abstract
  30. Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35 View Full Paper
  31. Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93 View Full Paper
  32. Ahn H et al. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016 Nov 23;20:36 View Full Paper
  33. Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811 View Full Paper
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