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Methyl B-Complex References

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  6. Smith AD et al.  Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 2010;5:e12244 View Abstract
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  9. B vitamins. Harvard T.H. Chan School of Public Health , The Nutrition Source, Vitamins and Minerals > B Vitamins. Available at: https://www.hsph.harvard.edu/nutritionsource/vitamins/vitamin-b/ (Accessed July 4, 2019)
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  14. Unpublished data, Quicksilver ScientificTM, B12 crossover study
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  17. de Jager J  et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.BMJ. 2010 May 20;340:c2181 View Full Paper
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  19. Vitamin B12 Fact Sheet for Consumers. June 24 2011 (cited 17 July 2017). Available from: https://ods.od.nih.gov/factsheets/VitaminB12-Consumer/
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  24. Li S, Chen X, Li Q, Du J et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial.J Diabetes Investig. 2016 Sep;7(5):777-85.  View Full Paper
  25. Korem M et al. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences 2005: 233: 93 – 97View Abstract
  26. Zhang Y et al. Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia. PLoS One. 2016 Jan 22;11(1):e0146797. View Full Paper
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  29. Smith AD et al. Vitamin B12. In: Advances in Food and Nutrition Research, Volume 83. Elsevier. 2018
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  31. Hoffman M. Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. Med Hypotheses. 2011;77:1088–93. View Abstract
  32. McCaddon A et al. L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer’s disease-related cognitive decline. CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5; discussion 6. Review. View Abstract
  33. Antoniades C et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J. 2009;30:6–15. View Abstract
  34. Moore LD et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38.View Full Paper
  35. Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol. 2008;15(2):72–75. View Full Paper
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  37. Borowa-Mazgaj B et al. Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicol Sci. 2019 May 14. pii: kfz110 View Full Paper
  38. Ligthart S et al.  DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255 View Full Paper
  39. Murphy TM et al. Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes Psychiatr Genet. 2015 Apr;25(2):71-8. View Abstract
  40. NIH U.S. National Library of Medicine, MTHFR gene. Genetics Home Reference Available at: https://ghr.nlm.nih.gov/gene/MTHFR Accessed 1-4-2020
  41. Castro R et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. Journal of Medical Genetics 2004;41:454-458View Full Paper
  42. McGuire BW et al. Pharmacokinetics of leucovorin calcium after intravenous, intramuscular, and oral administration. Clin Pharm 1988;7(1):52-58. [View Abstract]
  43. Malouf R et al. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev 2008;4:CD004514 View Abstract
  44. Smith AD et al.  Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 2010;5:e12244. View Full Paper
  45. Wang X et al. X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 2007;369:1876–82. View Abstract
  46. Malouf R, Grimley EJ.  The effect of vitamin B-6 on cognition. Cochrane Database Syst Rev 2006; (4):CD004393.
  47. Wang HX et al. Vitamin B(12) and folate in relation to the development of Alzheimer’s disease. Neurology 2001;56(9):1188–94.View Abstract
  48. Lewis J et al. The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression. ISRN Psychiatry 2013 Jan 21;2013:621453View Full Paper
  49. McNulty H et al. Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status. British Journal of Nutrition. 2008:99, Suppl. 3, S48–S54 View Abstract
  50. Spence JD. Nutrition and stroke prevention. Stroke 2006; 37: 2430–35.View Full Paper
  51. Coimbra CG et al. High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson’s disease patients. Brazilian Journal of Medical and Biological Research. 2003: 36(10), 1409–1417 View Abstract
  52. Wakade C et al. Niacin modulates macrophage polarization in Parkinson’s disease. J Neuroimmunol. 2018 Jul 15;320:76-79 View Abstract
  53. Wakade C et al. A novel treatment target for Parkinson’s disease J Neurol Sci. 2014 Dec 15;347(1-2):34-8 View Abstract
  54. Boehnke C et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: An open study in a tertiary care centre. European Journal of Neurology. 2004:11(7): 475–477. View Abstract
  55. Sedel F et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. MultSclerRelatDisord. 2015 Mar;4(2):159-69 View Abstract
  56. Pavlin M, Repic M et al. The chemistry of neurodegeneration: kinetic data and their implications. Mol Neurobiol 2015: (53):5: 3400–3415View Abstract
  57. Manore, MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am. J. Clin. Nutr. 2000: 72:598S-606S View Abstract
  58. Manore, MM. Nutritional needs of the female athlete. In Clinics in Sports Medicine: Nutritional Aspects of Exercise, K.B. Wheeler, and J.A. Lombardo (Eds.). Philadelphia: W.B. Sanders Company, 1999: 549-563.
  59. Fogelholm, M. Micronutrient status in females during a 24-week fitness-type exercise program. Ann. Nutr. Metab. 1992: 36:209-218 View Abstract
  60. Rokitzki L et al. Assessment of vitamin B-6 status of strength and speedpower athletes. J. Am. Coll. Nutr. 1994: 13:87-94 View Abstract
  61. Winters LR et al. Riboflavin requirements and exercise adaptation in older women. Am. J. Clin. Nutr. 1992: 56:526-532 View Abstract
  62. Raczynski G et al. Longitudinal studies on vitamin B-1 and B-6 status in Polish elite athletes. Biol. Sport. 1993: 10:189-194. View Abstract
  63. Telford RD et al. The effect of 7 to 8 months of vitamin/mineral supplementation on the vitamin and mineral status of athletes. Int. J. Sport Nutr. 1992: 2:123-134 View Abstract
  64. Abdou E et al. Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations. Neurochem Res 2014: (40): 2: 353–361View Abstract
  65. Ashoori M Riboflavin (vitamin B(2)) and oxidative stress: a review. Br J Nutr 2014: 111:1985–1991 View Abstract
  66. Digby JE et al. Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms. ArteriosclerThrombVasc Biol 2012: 32:669–676. View Abstract
  67. Morris JS et al. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. Journal of Nutrition, 2010: 140; 103–110. View Full Paper
  68. Mikkelsen K, Stojanovska L et al. The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas 2017; 96:58–71. View Abstract
  69. Baynes JW et al. Glycoxidation and lipoxidation in atherogenesis. Free Radical Biology & Medicine 2000: 28; 1708–1716 View Abstract
  70. Zhao G, He F. Betaine in inflammation: mechanistic aspects and applications. Front Immunol. 2018 May 24;9:1070 View Full Paper
  71. Federico A. Silymarin/Silybin and chronic liver disease: a marriage of many years. Molecules. 2017 Jan 24;22(2). pii: E191View Full Paper
  72. Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35View Full Paper
  73. Chang CY et al. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41View Abstract
  74. Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93View Full Paper
  75. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36View Full Paper
  76. Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier.  Int J Nanomedicine. 2014 Feb 7;9:795-811View Full Paper
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