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NAD+ Gold Methyl Charge Bundle References
NAD Gold+ References quicksilverscientific.com/nadgoldreferences/
- Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. View Abstract
- Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916 View Abstract
- Wu, L et al. The elusive NMN transporter is found. Nat Metab 2019: 1; 8-9 View Full Paper
- Rajman L et al. Therapeutic potential of NAD-Boosting molecules: The in vivo evidence. Cell Metab. 2018 Mar 6;27(3):529-547. View Abstract
- Li W et al. NAD+ Content and Its Role in Mitochondria. Mitochondrial Regulation. 2014: 39–48 View Abstract
- Lee CF et al. Targeting NAD+ metabolism as interventions for mitochondrial disease. Sci Rep. 2019 Feb 28;9(1):3073. View Abstract
- Schultz MB et al. Why NAD+ Declines during Aging: It’s Destroyed. Cell Metab. 2016 June 14; 23(6): 965–966 View Full Paper
- Davila, A et al. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 2018 Jun 12;7 View Full Paper
- Imai S. The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control. NPJ Syst Biol Appl. 2016 Aug 18;2:16018 View Full Paper
- Massudi H et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue PLoS One. 2012;7(7):e42357 View Abstract
- Zhu XH et al. In vivo NAD assay revels the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl. Acad. Sci. 2015; 112:2876–2881 View Full Paper
- Hershberger KA et al. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017 Apr;13(4):213-225. View Full Paper
- Gross CJ et al. Digestion and absorption of NAD by the small intestine of the rat J Nutr. 1983 Feb;113(2):412-20. View Abstract
- Poljsak B. NAMPT-Mediated NAD biosynthesis as the internal timing mechanism: in NAD+ World, time Is running in its own way. Rejuvenation Res. 2018 Jun;21(3):210-224 View Abstract
- Tsubota, K. The first human clinical study for NMN has started in Japan. NPJ Aging Mech. Dis. 2016, 2, 16021 View Abstract
- Strait, JE. Scientists identify new fuel-delivery route for cells. Washington University School of Medicine. Available at: https://medicine.wustl.edu/news/scientists-identify-new-fuel-delivery-route-for-cells/ Accessed: 9-14-2019
- Mills KF et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016: 24, 795–806. View Full Paper
- Anti-Aging compound in human clinical trial: will boosting NMN slow aging? Available at: https://hecmedia.org/posts/anti-aging-compound-in-human-clinical-trial-will-boosting-nmn-slow-aging-6/ Accessed 9-1-2019
- Guan Y et al. Nicotinamide Mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1-dependent manner. J Am Soc Nephrol. 2017 Aug;28(8):2337-2352. View Full Paper
- Martin As et al. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model.JCI Insight. 2017 Jul 20;2(14). View Full Paper
- Johnson S et al. NAD + biosynthesis, aging, and disease. F1000Res. 2018 Feb 1;7:132 View Full Paper
- Mills KF et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016; 24:795–806 View Full Paper
- Das A et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20 View Abstract
- Kathirvel E et al. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1068-77 View Full Paper
- Schmeisser K et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 2013;9(11):693–700. View Full Paper
- Bonkowski MS et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 November ; 17(11): 679–690 View Full Paper
- Kane AE et al. Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular disease. Circ Res. 2018 Sep 14;123(7):868-885. View Full Paper
- Sun WP et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. Clin Nutr, 2017. 36(4): p. 1136-1142 View Abstract
- Van der Meel R et al. Extracellular vesicles as drug delivery systems: lessons from the liposome field. J Control Release. 2014 Dec 10;195:72-85 View Abstract
- Yoshida M. Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice. Cell Metab. 2019 Aug 6;30(2):329-342.e5 View Abstract
- Yoshino J et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528 View Full Paper
- Gaddipati R et al. Visceral adipose tissue visfatin in nonalcoholic fatty liver disease. Ann Hepatol. 2010;9(3):266–70. View Abstract
- Revollo JR et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6(5):363–75 View Full Paper
- Caton PW et al. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated
- impairment of mouse islet function. Diabetologia. 2011;54(12):3083–92. View Abstract
- De Picciotto NE et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell 2016, 15, 522–530. View Full Paper
- Yoshino J et al. Nicotinamide mononucleotide, a key NAD (+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528–36 View Full Paper
- Uddin GM et al. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front. Pharmacol. 2016, 7, 258 View Full Paper
- Wei CC et al. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Sci. Rep. 2017, 7, 717 View Full Paper
- Wang X et al. Nicotinamide mononucleotide protects against –amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016, 1643, 1–9. View abstract
- Yao Z et al. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci. Lett. 2017, 647, 133–140. View Abstract
- Hou Y et al. NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc. Natl. Acad. Sci. USA 2018, 115, E1876–E1885 View Abstract
- Wei CC et al. NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia. Br J Pharmacol. 2017 Nov;174(21):3823-3836 View Full Paper
- Gomes AP et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013; 155, 1624–1638.View Full Paper
- Stromsdorfer KL et al. NAMPT-Mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice. Cell Rep. 2016 Aug 16;16(7):1851-60. View Abstract
- Camacho-Pereira J et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016; 23:1127–1139 View Full Paper
- Lin JB et al. NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep. 2016; 17:69–85 View Full Paper
- Sheedfar F et al. Liver diseases and aging: friends or foes? Aging Cell. 2013 Dec;12(6):950-4 View Abstract
- Hamaguchi M. Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women.
- World J Gastroenterol. 2012 Jan 21;18(3):237-43 View Full Paper
- Day CR et al. Betaine chemistry, roles, and potential use in liver disease. Biochim Biophys Acta. 2016 Jun;1860(6):1098-106 View Abstract
- Zhao G et al. Betaine in inflammation: mechanistic aspects and applications. Front Immunol. 2018 May 24;9:1070. View Full Paper
- Ueland PM et al. Betaine: a key modulator of one-carbon metabolism and homocysteine status.
- Clin Chem Lab Med. 2005;43(10):1069-75. View Abstract
- Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. View Abstract
Methyl Charge+™ References quicksilverscientific.com/methylchargereferences/
- McKee SE et al. Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition: considerations for future research Nutrition Reviews, 2018 (75): 7:497-511 View Full Paper
- Williams AC et al. Nicotinamide, NAD(P)(H), and methyl-group homeostasis evolved and became a determinant of ageing diseases: hypotheses and lessons from Pellagra. Curr Gerontol Geriatr Res. 2012;2012:302875. View Full Paper
- Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510. View Abstract
- Fang EF et al. NAD (+) in aging: molecular mechanisms and translational implications. Trends Mol Med. 2017;23(10):899–916 View Abstract
- Hershberger KA et al. Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nat Rev Nephrol. 2017 Apr;13(4):213-225. View Full Paper
- Tasselli L et el. Methylation gets into rhythm with NAD(+)-SIRT1Nat Struct Mol Biol. 2015 Apr;22(4):275-76 View Abstract
- Aguilar-Arnal L et al. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.Nat Struct Mol Biol. 2015 Apr;22(4):312-8. View Full Paper
- Cantó C et al. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 2015 Jul 7;22(1):31-53. View Full Paper
- Kang-Lee YA et al. Metabolic effects of nicotinamide administration in rats. J Nutr. 1983 Feb;113(2):215-21. View Abstract
- Aksoy S et al. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 1994 269, 14835–14840.
- Li W et al. NAD+ content and its role in mitochondria. Mitochondrial Regulation. 2014: 39–48 View Abstract
- Lee CF et al. Targeting NAD+ metabolism as interventions for mitochondrial disease. Sci Rep. 2019 Feb 28;9(1):3073. View Abstract
- Pelizzola M. The DNA methylome. FEBS Lett. 2011 Jul 7; 585(13): 1994–2000. View Full Paper
- Moore LD et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38.View Full Paper
- Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol. 2008;15(2):72–75. View Full Paper
- Friso S et al. One-carbon metabolism and epigenetics. Mol Aspects Med. 2017 Apr;54:28-36. View Abstract
- Shames DS, Minna JD et al. DNA methylation in health, disease, and cancer. Curr Mol Med 7: 85-102View Full Paper
- gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicol Sci. 2019 May 14. pii: kfz110 View Full Paper
- Ligthart S et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255 View Full Paper
- NIH U.S. National Library of Medicine, MTHFR gene. Genetics Home Reference Available at: https://ghr.nlm.nih.gov/gene/MTHFR Accessed 1-4-2020
- Castro R et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation. Journal of Medical Genetics 2004;41:454-458View Full Paper
- Hustad S et al. Riboflavin and methylenetetrahydrofolate reductase. Madame Curie Bioscience Database [Internet]. View Full Paper
- Pinto JT et al. Riboflavin. Advances in Nutrition 2016 (5):5;973-975 View Full Paper
- O’Leary F. Vitamin B12 in health and disease Nutrients. 2010 Mar;2(3):299-316. View Full Paper
- James JS, Melnyk S et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1): 425–430 View Full Paper
- Belardo A et al. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children J Nutr Biochem. 2019 Aug;70:38-46. View Abstract
- Anderson OS e al. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation.J Nutr Biochem. 2012 Aug;23(8):853-9. View Full Paper
- Spector AA et al. Membrane lipid composition and cellular function. J Lipid Res. 1985 Sep;26(9):1015-35View Full Paper
- Chang CY et al. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41View Abstract
- Porter CJ. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93View Full Paper
- Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport.Biomater Res. 2016 Nov 23;20:36View Full Paper
- Alyautdin R et al. Nanoscale drug delivery systems and the blood brain barrier. Int J Nanomedicine. 2014 Feb 7;9:795-811View Full Paper