[1] Heart disease facts. The Centers for Disease Control and Prevention. https://www.cdc.gov/heartdisease/facts.htm. Reviewed February 7th, 2022.
[2] Fan F and Saver JL. Abstract 169: Neurovascular Disease is the Second Leading Cause of Death in the United States (US): A Modern Disease Burden Analysis. Stroke. 2018; 49(Suppl 1): 169.
[3] Lavie CJ et al. Sedentary behavior, exercise, and cardiovascular health. Circ Res. 2019; 124(5): 799-815.
[4] Srour B et al. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ. 2019; 365: l1451.
[5] Juul F et al. Ultra-processed food consumption among US adults from 2001 to 2018. Am J Clin Nutr. 2022; 115(1): 211-221.
[6] Lindqvist PG et al. Low sun exposure habits are associated with a dose-dependent increased risk of hypertension: a report from the large MISS cohort. Photochem Photobiol Sci. 2021; 20: 285-292.
[7] Wallis DE et al. The “Sunshine deficit” and cardiovascular disease. Circulation. 2008; 118(14): 1476-1485.
[8] Vallat R et al. Broken sleep predicts hardened blood vessels. PLoS One. 2020; 18(6): e3000726.
[9] Gallo G et al. Endothelial dysfunction in hypertension: Current concepts and clinical implications. Front Med. 2022. https://doi.org/10.3389/fmed.2021.798958.
[10] Martins-Filho RK et al. Biomarkers related to endothelial dysfunction and vascular cognitive impairment: A systematic review. Dement Geriatr Cogn Disord. 2020; 49: 365-374.
[11] Stein RA. Endothelial dysfunction, erectile dysfunction, and coronary heart disease: The pathophysiologic and clinical linkage. Rev Urol. 2003; 5(Suppl 7): S21-S27.
[12] Hendrickse P and Degens H. The role of the microcirculation in muscle function and plasticity. J Muscle Res Cell Motil. 2019; 40(2): 127-140.
[13] Sorland K et al. Reduced endothelial function in myalgic encephalomyelitis/chronic fatigue syndrome–results from open-label cyclophosphamide intervention study. Front Med. 2021. https://doi.org/10.3389/fmed.2021.642710.
[14] Li ZM et al. Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics. Acta Pharmacologica Sinica. 2018; 39: 802-824.
[15] Wu M et al. Roles and mechanisms of hawthorn and its extracts on atherosclerosis: A review. Front Pharmacol. 2020; 11: 118.
[16] Dood KP et al. The effect of Hawthorn extract on coronary flow. J Evid Based Complementary Altern Med. 2013; 18(4): 257-267.
[17] Zhao H and Luo Y. Traditional Chinese Medicine and aging intervention. Aging Dis. 2017; 8(6): 688-690.
[18] Duan L et al. Panax notoginseng saponins for treating coronary artery disease: A functional and mechanistic overview. Front Pharmacol. 2017; https://doi.org/10.3389/fphar.2017.00702.
[19] Zhao H et al. Therapeutic potential and cellular mechanisms of Panax Notoginseng on prevention of aging and cell senescence-associated diseases. Aging Dis. 2017; 8(6): 721-739.
[20] Ramirez R et al. Endothelial senescence and chronic vascular diseases: Challenges and therapeutic opportunities in atherosclerosis. J Pers Med. 2022; 12(2): 215.
[21] Sun K et al. Effect of Panax notoginseng saponins on lipopolysaccharide-induced adhesion of leukocytes in rat mesenteric venules. Clin Hemorheol Microcirc. 2006; 34(1-2): 103-108.
[22] Xu D et al. Efficacy and safety of Panax notoginseng saponin therapy for acute intracerebral hemorrhage, meta-analysis, and mini review of potential mechanisms of action. Front Neurol. 2014; 5: 274.
[23] Tabassum NE et al. Ginkgo biloba: A treasure of functional phytochemicals with multimedicinal applications. Evid Based Complement Alternat Med. 2022; 2022: 8288818.
[24] Mesquita TRR et al. Cardioprotective action of ginkgo biloba extract against sustained β-adrenergic stimulation occurs via activation of M2/NO Pathway.
[25] Mashayekh A et al. Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study. Neuroradiology. 2011; 53(3): 185-191.
[26] Shang C et al. Beneficial effects of cinnamon and its extracts in managing cardiovascular diseases and diabetes. Food Funct. 2021; 12: 12194-12220.
[27] Allerton TD et al. l-citrulline supplementation: Impact on cardiometabolic health. Nutrients. 2018; 10(7): 921.
[28] Khalaf D et al. The effects of oral l-arginine and l-citrulline supplementation on blood pressure. Nutrients. 2019; 11(7): 1679.
[29] Figueroa A et al. Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Curr Opin Clin Nutr Metab Care. 2017; 20(1): 92-98.
[30] Zhang L et al. and Chen J. Biological effects of tetrahydroxystilbene glucoside: An active component of a rhizome extracted from Polygonum multiflorum. Oxid Med Cell Longev. 2018; 2018; 3641960.
[31] Liu LP et al. The protective effects of Polygonum multiflorum stilbeneglycoside preconditioning in an ischemia/reperfusion model of HUVECs. Acta Pharmacologica Sinica. 2010; 31: 405-412.
[32] Gu W et al. Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin-resistant rats. BMC Complement Med Ther. 2020; 20: 107.
[33] Younis NS et al. Protective effects of myrrh essential oil on isoproterenol-induced myocardial infarction in rats through antioxidant, anti-inflammatory, Nrf2/HO-1, and apoptotic pathways. J Ethnopharmacol. 2021; 270(113793).
[34] Siddiqui MZ. Boswellia Serrata, a potential antiinflammatory agent: An overview. Indian J Pharm Sci. 2011; 73(3): 255-261.
[35] Cao B et al. Seeing the unseen of the combination of two natural resins, Frankincense and Myrrh: changes in chemical constituents and pharmacological activities. Molecules. 2019; 24(17): 3076.
[36] Wang M et al. Pretreatment with β-boswellic acid Improves blood stasis induced endothelial dysfunction: Role of eNOS activation. Sci Rep. 2015; 5: 15357.
[37] Mehrzadi S et al. The effects of Boswellia serrata gum resin on the blood glucose and lipid profile of diabetic patients: A double-blind randomized placebo-controlled clinical trial. J Evid Based Integr Med. 2018; https://doi.org/10.1177/2515690X18772728.