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DIM References

  1. Navarro SL, et al. Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults. J Nutr. 2014; 144(11): 1850-1857.
  2. Yoshida K, et al. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. World J Gastroenterol. 2015; 21(35): 10091-10103.
  3. Royston KJ, et al. The epigenetic impact of cruciferous vegetables on cancer prevention. Curr Pharmacol Rep. 2015; 1(1): 46-51.
  4. Rajoria S, et al. 3,3′-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: A pilot study. Thyroid. 2011; 21(3): 299-304.
  5. Thomson CA, et al. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat. 2017; 165(1): 97-107.
  6. Ashrafian L, et al. Double-blind randomized placebo-controlled multicenter clinical trial (phase IIa) on diindolylmethane’s efficacy and safety in the treatment of CIN: implications for cervical cancer prevention. EPMA J. 2015; 6: 25.
  7. Sepkovic DW, et al. Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism and enhances immune response in the K14-HPV16 transgenic mouse model. Cancer Epidemiol Biomarkers Prev. 2009; 18(11): 2957-2964.
  8. Choi KM and Yoo HS. 3,3′‐Diindolylmethane enhances glucose uptake through activation of insulin signaling in 3T3‐L1 adipocytes. Obesity. 2018; 26(7): 1153-1160.
  9. Zhang WW, et al. Multiple therapeutic and preventive effects of 3,3′-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia. J Biomed Res. 2014; 28(5): 339-348.
  10. Xue L, et al. 3,3′-Diindolylmethane stimulates murine immune function in vitro and in vivo. J Nutr Biochem. 2008; 19(5): 336-344.
  11. Cho HJ, et al. 3,3′-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. J Nutr. 2008; 138(1): 17-23.
  12. Ampofo E, et al. Targeting the microcirculation by indole-3-carbinol and its main derivate 3,3,’-diindolylmethane: Effects on angiogenesis, thrombosis, and inflammation. Mini Rev Med Chem. 2018; 18(11): 962-968.
  13. Rouse M, et al. 3,3′-Diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through MicroRNA signaling pathways. J Pharmacol Exp Ther. 2014; 350(2): 341-352.
  14. Saw CLL, et al. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated Phase II drug-metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos. 2011; 32(5): 289-300.
  15. Fuentes F, et al. Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3,3′-diindolylmethane: Anti-oxidative stress/inflammation, Nrf2, epigenetics/epigenomics and in vivo cancer chemopreventive efficacy. Curr Pharmacol Rep. 2015; 1(3): 179-196.
  16. Wu TY, et al. Pharmacokinetics and pharmacodynamics of 3,3′-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes. J Pharmacokinet Pharmacodyn. 2015; 42(4): 401-408.
  17. Godugu C, et al. Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer. Eur J Pharm Biopharm. 2016; 108: 168-179.
  18. Yang Z, et al. Effect of liposomes on the absorption of water-soluble active pharmaceutical ingredients via oral administration. Curr Pharm Des. 2013; 19(37): 6647-6654.
  19. Alyautdin R, et al. Nanoscale drug delivery systems and the blood-brain barrier. Int J Nanomedicine. 2014; 9: 795-811.
  20. Ahn H, et al. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016; 20: 36.
  21. Spector AA, et al. Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9): 1015-1035.
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