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Immune Support Bundle References

D3K2 References quicksilverscientific.com/d3k2references/

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  4. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. The American journal of clinical nutrition. 2008 Aug 1;88(2):491S-9S. View Abstract
  5. Melamed ML et al. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008 Aug 11;168(15):1629-37. View Abstract
  6. Tripkovic L et al Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95(6):1357–1364. View Full Paper
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  8. White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008 Sep;76(9):3837-43. View Full Paper
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  16. Martineau AR et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. View Absract
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  19. Quraishi SA, Bittner EA, Christopher KB, Camargo CA Jr. Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. PLoS One. 2013 Nov 15;8(11):e81120. View Full Paper
  20. Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013 Feb;202:100-7. View Full Paper
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  23. Penckofer S et al. Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes. J Diabetes Res. 2017 Sep 7;2017:8232863. View Abstract
  24. Gloth FM 3rd, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging. 1999;3(1):5-7. View Abstract
  25. Landel V et al. Vitamin D, cognition and Alzheimer’s Disease: the therapeutic benefit is in the D-Tails. J. Alzheimers Dis. 2016;53(2):419–444. View Full Paper
  26. Goodwill AM. A systematic review and meta-analysis of the effect of low vitamin D on cognition. J Am Geriatr Soc. 2017 Oct;65(10):2161-2168. View Abstract
  27. Morello M. Vitamin D improves neurogenesis and cognition in a mouse model of Alzheimer’s disease. Mol Neurobiol. 2018 Aug;55(8):6463-6479. View Full Paper
  28. Gangwar AK et al. Role of Vitamin-D in the prevention and treatment of Alzheimer’s disease. Indian J Physiol Pharmacol. 2015 Jan;59(1):94–9. View Abstract
  29. Yin Yet al. Nutrient biomarkers and vascular risk factors in subtypes of mild cognitive impairment: a cross-sectional study. J Nutr Health Aging. 2015 Jan;19(1):39–47. View Abstract
  30. Wood JM et al. Vitamin D and neurocognitive disorder due to Alzheimer’s disease: A review of the literature. Ann Clin Psychiatry. 2015 Aug;27(3):206–12. View Abstract
  31. Mheid IA et al. Vitamin D and cardiovascular disease. State-of-the-Art-Review. Journal of the American College of Cardiology 2017 (70):1: 89-100 View Abstract
  32. Rai V et al. Role of vitamin D in cardiovascular diseases.Endocrinol Metab Clin North Am. 2017 Dec;46(4):1039-1059 View Abstract
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  34. Khan A et al. Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3 – clinical implications for cardiovascular diseases.Int J Nanomedicine. 2018 Jan 19;13:455-466. View Abstract
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  36. Burkes RM et al. Associations among 25-Hydroxyvitamin D levels, lung function, and exacerbation outcomes in COPD: An analysis of the SPIROMICS cohort. Chest. 2020 Jan 17. View Abstract
  37. Sluyter JD et al. Effect of monthly, high-dose, long-term vitamin D on lung function: a randomized controlled trial. Nutrients [Internet]. 2017 Dec 13;9(12). View Abstract
  38. Bügel S. Vitamin K and bone health in adult humans. Vitam Horm. 2008;78:393-416. View Abstract
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Microb-Manager™ References quicksilverscientific.com/microbmanagerreferences/

  1. Aslam B, et al. Antibiotic resistance: a rundown of a global crisis. Infect Drug Res. 2018; 11: 1645-1658.
  2. “Antibiotic/antimicrobial Resistance (AR/AMR): Biggest threats and data.” Centers for Disease Control and Prevention. 10 Sept 2018. https://www.cdc.gov/drugresistance/biggest_threats.html.
  3. Gupta PD, Birdi TJ. Development of botanicals to combat antibiotic resistance. J Ayurveda Integr Med. 2017; 8(4): 266-275.
  4. Feng J, et al. A drug combination screen identifies drugs active against amoxicillin-induced round bodies of in vitro Borrelia burgdorferi persisters from an FDA drug library. Front Microbiol. 2016; 7: 743.
  5. Kim WS, et al. Anti-inflammatory, antioxidant and antimicrobial effects of artemisinin extracts from artemisia annua L. Korean J Physiol Pharmacol. 2015; 19(1): 21-27.
  6. Appalasamy S, et al. Antimicrobial activity of artemisinin and precursor derived from in vitro plantlets of artemisia annua L. Biomed Res Int. 2014; 2014: 215872.
  7. Fiamegos YC, et al. Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. PLoS One. 2011; 6(4): e18127.
  8. Liu X, et al. Antifungal compounds against Candida infections from traditional Chinese medicine. Biomed Res Int. 2017; 2017: 4614183.
  9. Dziedzic A, et al. Inhibition of oral Streptococci growth induced by the complementary action of berberine chloride and antibacterial compounds. Molecules. 2015; 20(8): 13705-13724.
  10. Feng J, et al. Selective essential oils from spice or culinary herbs have high activity against stationary phase and biofilm Borrelia burgdorferiFront Med (Lausanne). 2017; 4: 169.
  11. Rao PV, Gan SH. Cinnamon: A multifaceted medicinal plant. Evid Based Complement Alternat Med. 2014; 2014: 642942.
  12. “Cannabidiol is a powerful new antibiotic.” American Society for Microbiology. 23 June 2019. https://www.asm.org/Press-Releases/2019/June/Cannabidiol-is-a-Powerful-New-Antibiotic.
  13. Teow SY, et al. Antibacterial action of curcumin against Staphylococcus aureus: A brief review. J Trop Med. 2016; 2016: 2853045.
  14. Moghadamtousi SZ, et al. A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Res Int. 2014; 2014: 186864.
  15. Dou Y, et al. Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis.” J Neuroinflamm. 2018; 5: 6.
  16. Isacchi B, et al. Artemisinin and artemisinin plus curcumin liposomal formulations: Enhanced antimalarial efficacy against Plasmodium berghei-infected mice. Eur J Pharm Biopharm. 2012; 80(3): 528-534.
  17. Toden S, et al. Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis. Sci Rep. 2017; 7: 814.
  18. Ismail SM, et al. Antimicrobial activity of frankincense of Boswellia serrata. Int J Curr Microbiol App Sci. 2014; 3(10): 1095-1101.
  19. Raja AF, et al. Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens. BMC Res Notes. 2011; 4: 406.
  20. Siddiqui MZ. Boswellia Serrata, a potential antiinflammatory agent: An overview. Indian J Pharm Sci. 2011; 73(3): 255-261.
  21. Umar S, et al. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine. 2014; 21(6): 847-856.
  22. Raja AF, et al. Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata. BMC Microbiol. 2011; 11: 54.
  23. Haroyan A, et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018; 18: 7.
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  25. Weng Z, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012; 7(3): e33805.
  26. Johnzon CF, et al. The role of mast cells in bacterial infection. Am J Pathol. 2016; 186(1): 4-14.
  27. Okhuarobo A, et al. Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology. Asian Pac J Trop Dis. 2014; 4(3): 213-222.
  28. Pongtuluran OB, et al. Antiviral and immunostimulant activities of Andrographis paniculata. HAYATI J Biosci. 2015; 22(2): 67-72.
  29. Mishra PK, et al. Antibacterial activity of Andrographis paniculata (Burm. f.) Wall ex Nees leaves against clinical pathogens. J Pharm Res. 2013; 7(5): 459-462.
  30. Al-Hariri M. Immune’s-boosting agent: Immunomodulation potentials of propolis. J Family Community Med. 2019; 26(1): 57-60.
  31. Przybylek I, Karpinski TM. Antibacterial properties of propolis. Molecules. 2019; 24(11): 2047.
  32. Silvo-Carvalho L, et al. Propolis: A complex natural product with a plethora of biological activities that can be explored for drug development. Evid Based Complement Alternat Med. 2015; 2015: 206439.
  33. Aderibigbe BA. Design of drug delivery systems containing artemisinin and its derivatives. Molecules. 2017; 22(2): 323.
  34. Zgair A, et al. Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. Am J Transl Res. 2016; 8(8): 3448-3459.
  35. Luo X, et al. Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO4 gradient method. Asian J Pharm Sci. 2013; 8(4): 261-266.
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  37. Yao L, et al. Novel berberine derivatives: Design, synthesis, antimicrobial effects, and molecular docking studies. Chin J Nat Medicines. 2018; 16(10): 774-781.
  38. Yu Y, et al. Anti-inflammatory effects of curcumin in microglial cells. Front Pharmacol. 2018; 9: 386.
  39. Nie X, et al. Attenuation of innate immunity by andrographolide derivatives through NF-κB signaling pathway. Sci Rep. 2017; 7: 4738.
  40. Orsatti CL, et al. Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice. Phytother Res. 2010; 24(8): 1141-1146.
  41. Governa P, et al. Effects of Boswellia Serrata Roxb. and Curcuma longa L. in an in vitro intestinal inflammation model using immune cells and Caco-2. Pharmaceuticals (Basel). 2018; 11(4): 126.
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Vitamin C References quicksilverscientific.com/vitamincreferences/

  1. Pehlivan FE. Vitamin C: An antioxidant agent. InTechOpen. 2017; [online]
  2. Lenton KJ, et al. Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am J Clin Nutr. 2003; 77(1): 189-195.
  3. Carpenter KJ. The discovery of vitamin C. Ann Nutr Metab. 2012; 61(3): 259-264.
  4. Pullar JM, et al. The roles of vitamin C in skin health. Nutrients. 2017; 9(8): 866.
  5. Malmir H, et al. Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies. Br J Nutr. 2018; 119(8): 847-858.
  6. Panush RS, et al. Modulation of certain immunologic responses by vitamin C. III. Potentiation of in vitro and in vivo lymphocyte responses. Int J Vitam Nutr Res Suppl. 1982; 23: 35-47.
  7. Elste V, et al. Emerging evidence on neutrophil motility supporting its usefulness to define vitamin C intake requirements. Nutrients. 2017; 9(5): pii: E503.
  8. Hemila H. Vitamin C and infections. Nutrients. 2017; 9(4): 339.
  9. Travica N, et al. Plasma vitamin C concentrations and cognitive function: A cross-sectional study. Front Aging Neurosci. 2019; 11: 72.
  10. Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med. 2009; 46(6): 719-730.
  11. Kocot J, et al. Does vitamin C influence neurodegenerative diseases and psychiatric disorders? Nutrients. 2017; 9(7): pii: E659.
  12. Gillberg L, et al. Vitamin C – A new player in regulation of the cancer epigenome. Semin Cancer Biol. 2018; 51: 59-67.
  13. Young JI, et al. Regulation of the epigenome by vitamin C. Annu Rev Nutr. 2015; 35: 545-564.
  14. Mustafi S, et al. Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer. E Bio Medicine. 2019; 43: 102-210.
  15. Mustafi S, et al. Vitamin C sensitizes melanoma to BET inhibitors. Cancer Res. 2018; 78(2): 572-583.
  16. Pires AS, et al. Ascorbic acid chemosensitizes colorectal cancer cells and synergistically inhibits tumor growth. Front Physiol. 2018; 9: 911.
  17. May JM, Harrison FE. Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal. 2013; 19(17): 2068-2083.
  18. Ashor AW, et al. Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomised controlled trials. Atherosclerosis. 2014; 235(1): 9-20.
  19. Juraschek SP, et al. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012; 95(5): 1079-1088.
  20. Ellulu MS, et al. Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial. Drug Des Devel Ther. 2015; 9: 3405-3412.
  21. Basili S, et al. Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers. JACC Cardiovasc Interv. 2010; 3(2): 221-229.
  22. Dingchao H, et al. The protective effects of high-dose ascorbic acid on myocardium against reperfusion injury during and after cardiopulmonary bypass. Thorac Cardiovasc Surg. 1994; 42(5): 276-278.
  23. Schleicher RL, et al. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009; 90(5): 1252-1263.
  24. Nishikawa F, et al. Ascorbate metabolism in harvested broccoli. J Experiment Bot. 2003; 54(392): 2439-2448.
  25. Sapei L, Hwa L. Study on the kinetics of vitamin C degradation in fresh strawberry juices. Procedia Chem. 2014; 9: 62-68.
  26. Li Y, Schellhorn HE. New developments and novel therapeutic perspectives for vitamin C. J Nutr. 2007; 137(10): 2171-2184.
  27. Davis JL, et al. Liposomal-encapsulated ascorbic acid: Influence on vitamin C bioavailability and capacity to protect against ischemia–reperfusion injury. Nutr Metab Insights. 2016; 9: 25-30

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