[1] Otin CL et al. The hallmarks of aging. Cell. 2013; 153(6): 1194-1217.

[2] Rajman L et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018; 27(3): 529-547.

[3] Ruderman NB et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010; 298(4): E751-E760.

[4] Houtkooper RH, et al. Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol. 2012; 13(4): 225-238.

[5] Jesko H, et al. Sirtuins and their roles in brain aging and neurodegenerative disorders. Neurochem Res. 2017; 42(3): 876-890.

[6] Dodig S et al. Hallmarks of senescence and aging. Biochem Med (Zagreb). 2019; 29(3): 030501.

[7] Lee KA et al. Immune senescence, immunosenescence, and aging. Front Aging. 2022. [online].

[8] Honda S et al. Cellular senescence promotes endothelial activation through epigenetic alteration and consequently accelerates atherosclerosis. Sci Rep. 2021; 11: 14608.

[9] Bussian TJ et al. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature. 2018; 562(7728): 578-582.

[10] Bielak-Zmijewska A et al. The role of curcumin in the modulation of ageing. Int J Mol Sci. 2019; 20(5): 1239.

[11] Zendedel E et al. Impact of curcumin on sirtuins: A review. J Cell Biochem. 2018; 119(12): 10291-10300.

[12] Yang Y et al. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia-reperfusion injury. Free Radic Biol Med. 2013; 65: 667-679.

[13] Sun MS et al. Free radical damage in ischemia-reperfusion injury: An obstacle in acute ischemic stroke after revascularization therapy. Oxid Med Cell Longev. 2018; 2018: 3804979.

[14] Lagouge M et al. The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med. 2013; 273(6): 529-543.

[15] Barra V et al. Specific irreversible cell-cycle arrest and depletion of cancer cells obtained by combining curcumin and the flavonoids quercetin and fisetin. Genes. 2022; 13(7): 1125.

[16] Benameur T et al. Curcumin as prospective anti-aging natural compound: Focus on brain. Molecules. 2021; 26(16): 4794.

[17] Mohar DS and Malik S. The sirtuin system: The holy grail of resveratrol? J Clin Exp Cardiolog. 2012; 3(11): 216.

[18] Moraes DS et al. Sirtuins, brain and cognition: A review of resveratrol effects. IBRO Rep. 2020; 9: 46-51.

[19] Borzoi D et al. Resveratrol as a promising polyphenol in age-associated cardiac alterations. Oxid Med Cell Longev. 2022; 2022: 7911222.

[20] Duggal NA. Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions. Biogerontol. 2018; 19: 481-496.

[21] Guo XF et al. Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2018; 58(17): 3016-3029.

[22] You W et al. Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep. 2019; 9: 19176.

[23] Zoico E et al. Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence. Sci Rep. 2021; 11: 23237.

[24] Lewinska A et al. AMPK-mediated senolytic and hemostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. Redox Biol. 2020; 28: 101337.

[25] Jiang YH et al. Quercetin attenuates atherosclerosis via modulating oxidized LDL-induced endothelial cellular senescence. Front Pharmacol. 2020; 11: 512.

[26] Hu T et al. Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in DB/DB mice. J Cell Mol Med. 2020; 24(6): 3449-3459.

[27] Jeandet P et al. Deciphering the role of phytoalexins in plant-microorganism interactions and human health. Molecules. 2014; 19(11): 18033-18056.

[28] Cheng Y et al. SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia-reperfusion injury. Apoptosis. 2016; 21(8): 905-916.

[29] Suarez-Rivero J et al. Pterostilbene in combination with mitochondrial cofactors improve mitochondrial function in cellular models of mitochondrial diseases. Sec Experimental Pharmacology and Drug Discovery. 2022. [online].

[30] Wodrich APK et al. The unfolded protein responses in health, aging, and neurodegeneration: Recent advances and future considerations. Front Mol Neurosci. 2022; 15: 831116.

[31] Liu W et al. Oral bioavailability of curcumin: problems and advancements. J Drug Target. 2016; 24(8): 694-702.

[32] De Vries K et al. A brief updated review of advances to enhance resveratrol’s bioavailability. Molecules. 2021; 26(14): 4367.

[33] Berkel Kasikci M et al. Bioavailability of quercetin. Curr Res Nutr Food Sci. 2016; [online].

[34] Hanif M et al. Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system. Drug Dev Ind Pharm. 2021; 47(9): 1432-1438.

[35] Balata GF et al. Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol. Drug Des Devel Ther. 2016; 10: 117-128.

[36] Sirvi A et al. Supersaturable self-emulsifying drug delivery system: A strategy for improving the loading and oral bioavailability of quercetin. J Drug Deliv Sci Technol. 2022; 71: 103289.