Every day, your three-pound liver saves your life. The second largest organ in your body (after the skin), your liver works tirelessly to keep you healthy—performing a stunning array of tasks. This workhorse filters everything you eat and drink, helps usher toxins safely out of the body, regulates blood sugar levels, stores extra sugar in the form of glycogen, and converts extra carbohydrate and protein into forms that can be stored for later use. Your liver also produces the body’s “liquid gold”—bile—which breaks down fats so they can be absorbed, and carries waste out in the stool. Your liver even breaks down old or injured blood cells. It stores iron. It stores clotting molecules for the blood.
It’s versatile, your liver. But it is not invulnerable. Even this remarkable organ can be excessively burdened by the onslaught of toxicants so common in everyday life—chemicals, poor food, sweet snacks and sodas, excess alcohol, pollution and the constant stress we all face today. We are routinely exposed to over 84,000 chemicals (many untested for safety because they were grandfathered in by the Toxic Substances Act). Then there is our “obesogenic” food environment, which tempts us to eat high-fat, sugary, refined foods that seem to beckon from every television commercial, store, and restaurant, and place a significant burden on the liver’s detoxification system. Finally, the liver is impacted by chronic stress, a feature of contemporary life—which can lead to chronic high levels of cortisol, and contribute to fatty liver. According to the Mayo Clinic, nonalcoholic fatty liver disease is common in the United States, affecting an estimated 80 to 100 million people.
Liver rejuvenation supports better health in the body – from cholesterol and hormone metabolism to detoxification, energy and even cognitive function.
How to Know When Your Liver is Overtaxed
What are the early signs and symptoms of an overtaxed or stressed liver? Are there telltale warning signals that your liver could benefit from a little loving care and extra detox? Here are seven tips your liver may indeed need some attention.
Fatigue is a common complaint the world over and is often experienced when the liver is under stress. The liver converts glucose into glycogen, a form of sugar that can be stored, and then later released as glucose when the body needs a burst of energy. By storing and supplying the body with glucose, the liver helps provide energy and combat fatigue. If the liver is stressed it may become less efficient at regulation of blood glucose. Fatigue and sugar cravings may pop up.
Hormone Imbalances and Premenstrual Syndrome
The liver detoxifies more than chemicals and pollutants. It also detoxifies our own hormones, including excess estrogen. Not surprisingly, when liver function is impaired, excess estrogen may not be adequately bound and excreted. Signs of excess estrogen in women can include PMS, fibrocystic breasts, moodiness, weight gain, menstrual disturbances, fibroids and more.
Belly Bloat and Excessive Gas
When the flow of bile is stagnant or slowed, the gut shifts towards a state of dysbiosis, where unfriendly flora dominate, and constipation is common. The toxins from pathogenic bacteria then block detoxification pathways in the liver as well. With the resulting imbalance of flora and dysbiosis, excessive gas and bloating may be experienced after eating.
High Levels of Heavy Metals
Human exposure to heavy metals has soared, due to an exponential increase of metals in industrial, agricultural, and technological applications. From coal burning power plants to plastics, textiles, electronics, wood preservation, and paper processing, metals are ubiquitous in everyday life. Heavy metals can cause DNA damage and contribute to a variety of human illnesses. When the liver’s detoxification pathways are impaired, heavy metals can accumulate in the body. In particular, the liver’s stores of glutathione, which safely and effectively binds to toxins and metals, can be depleted.
A comprehensive tri-test that assesses urine, blood, and hair levels of mercury can give a realistic picture of an individual’s mercury burden. Other tests can look at glutathione levels, and levels of other metals in hair.
Chemical sensitivities and allergies
When the liver is under stress, individuals may find themselves more reactive to chemical exposures, including gasoline, kerosene, natural gas, pesticides, solvents, new carpet, adhesives, glues, fabric softener, formaldehyde, cleaning agents, medications and more.
Seasonal pollen allergies may worsen, and food sensitivities may increase. The liver is responsible for breaking down excess histamine, and if it is sluggish, histamine may build up in the body. In individuals with chronic cholestasis and impaired bile flow, blood levels of histamine have been found to be significantly greater than normal.
Nearly 60 million Americans are affected by the sleep disorders every year. Sleep problems run the gamut, taking too long to fall asleep (called sleep latency), waking up too early, fitful and poor sleep quality, frequent nocturnal awakening, or early morning awakening. The solutions range from sleeping medications to cognitive reframing techniques, relaxation tapes, meditation, sleep hygiene, and more. But one simple solution may be to improve liver function. Sleep disturbances have long been observed in chronic liver conditions, and one mechanism may be impaired hepatic melatonin metabolism. Melatonin is the “circadian rhythm” hormone—the hormone our bodies naturally release as darkness falls, and which readies us for a good night’s sleep.
5 Ways to Cleanse and Support Your Liver
Your liver is the only visceral organ in your body that can actually regenerate itself. If even a mere quarter of your original liver is left, it can regenerate back to its full size. Your liver’s capacity for repair is immense. It just needs a little extra care and attention. Here are some tips for improving your liver function.
1. Support bile flow with bitter botanicals
Bitter botanicals have been used for hundreds of years as both medicine and as aperitifs. They can aid in healthy drainage of the liver, kidneys, lymph, and help support intestinal health. First and foremost, they support healthy bile flow, which is critical for digestive function, and helps balance your gut flora, since bile acids are antimicrobial., Remember, toxins and their metabolites are removed from the liver into the bile, and out of the body via the stool.
The classic bitter botanicals are potent yet gentle. They include gentian, milk thistle, goldenrod, myrrh, and dandelion. Gentian is often called our most bitter bitter, offering digestive and liver support. Gentian has been shown to increase levels of our most potent endogenous antioxidant, glutathione; it may also support bile flow., Milk thistle (Silybum marianum) has a reputation as a potent liver protector, also with bitter properties. Its most active molecule, silymarin, has been shown to enhance glutathione levels in the liver and gut. Dandelion is widely known for its tonic function on the liver, gallbladder, and kidneys. Goldenrod helps the flow of bile. Myrrh has antimicrobial properties and supports bile flow as well.
2. Support the Liver with Pure Phosphatidylcholine
Phosphatidylcholine (PC) makes up 90% of the phospholipids in bile.In the body phosphatidylcholine supports the movement of toxins in the liver, aiding in detoxification. Phosphatidylcholine is also a primary building block for the guts protective mucus layer.
3. Support Glutathione Levels
Your liver’s ability to transform toxic molecules into less toxic ones, and then help your body excrete them, depends on two phases of detoxification. Phase I liver detoxification utilizes specialized enzymes to help neutralize innumerable substances. Phase II detoxification goes even further, and neutralizes the byproducts of Phase I. Then the toxins are removed from the body. To detoxify, your liver relies on many enzymes and molecules, but the most important may be glutathione. Levels of glutathione are naturally higher in the liver than the rest of your body.
4. Mop up Toxins with a Comprehensive Blend of Binders
Many toxins are reabsorbed after excretion into the bile. In addition, endotoxins from unfriendly gut bacteria, as well as bacteria themselves, can actually move through an inflamed gut lining directly into the bloodstream. This is known as microbial translocation and is associated with immune activation and inflammation. This puts more stress on the liver.
There is no universal binder that has an equal affinity for all toxins. However, a blend of natural molecules that effectively bind a wide array of toxins can help lessen the load on our bodies. Binders to consider include bentonite clay, activated charcoal, chitosan, and thiol-functionalized silica. Because each has a special affinity for certain types of toxins, a blend will offer broader protection.
5. Support the Gut with Soothing Natural Pre-Biotic Gums and Fibers
Because binders can be constipating, consider soothing supplements such as acacia gum, which serves as a prebiotic fiber, and aloe vera, which has long been used in traditional medicine to soothe inflamed tissues. These support the health of the intestinal lining, normal gut motility and the growth of friendly flora, all of which can help improve liver function.
by QUICKSILVER SCIENTIFIC EDUCATION TEAM
Tang W, Yi C, Kalitsky J, et al. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats. Mol Cell Biol Res Commun. 2000 Aug;4(2):90-7. View Abstract
Bradl H, editor. Heavy Metals in the Environment: Origin, Interaction and Remediation Volume 6. London: Academic Press; 2002.
Chang LW, Magos L, Suzuki T, editors. Toxicology of Metals. Boca Raton. FL, USA: CRC Press; 1996
Kaplowitz N. The importance and regulation of hepatic glutathione. Yale J Biol Med. 1981 Nov-Dec; 54(6): 497–502.
Tremblay S, Romain G, Roux M, et al. Bile Acid Administration Elicits an Intestinal Antimicrobial Program and Reduces the Bacterial Burden in Two Mouse Models of Enteric Infection. Infect Immun. 2017 May 23;85(6). pii: e00942-16. View Full Paper
Lian LH, Wu YL, et al. Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation. J Agric Food Chem. 2010 Dec 22;58(24):13013-9. View Abstract