Detoxification is a natural process inherent to the human body. Our bodies, over time, accumulate a variety of toxins from our environment, food sources and toxic emotions and become less effective at this process. Efficient detoxification depends on a series of seamless reactions that bind toxins to shuttle molecules and “escort” them out through a series of doors. The glutathione system is the most important of the detoxification systems and includes glutathione and the enzymes that work with it. The process of detoxification proceeds in three parts or “phases”, Phase I, II, and III. Dysfunction of the human detoxification system is the most common and insidious root cause of toxic element and compound accumulation in the body. True health requires that all phases are functioning and balanced or the whole system can not work properly.
The Human Detoxification System
Successful Detoxification of Mercury and other Heavy Metals (e.g. lead, cadmium, arsenic) requires three Fundamental Conditions:
1. Fully-functioning Phase III detoxification transport system (MRP1&2, OATP)
2. Fully-functioning Phase II enzyme, Glutathione S-transferase (GST)
3. Adequate intracellular glutathione levels
Quicksilver Scientific’s Therapeutic Detoxification System is the ONLY detox system that specifically targets all three detoxification requirements!
Disruptions in Natural Body-wide Detoxification
Intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the body’s natural detoxification pathways. Unfortunately, exposure to pesticides, chemicals and certain toxins, such as the corrosion by-products of dental mercury amalgam (”silver” fillings) contributes to intestinal inflammation. In addition to inflammation, it has been demonstrated that a build up of metals alone slows the transport proteins. The data suggests that continuous removal of metals from the intestines is essential for the proper daily functioning of natural detoxification processes. The continuous removal of metals is also critical for any successful practitioner-directed detoxification program.
Consequences of Impaired Detoxification
• Downregulation of toxin transporters
• Downregulation of Phase II detoxification enzymes
• Underexpression of cellular antioxidants
• Relative overexpression of oxidative Phase I enzymes
• Systemic toxicity and oxidative stress!
• Increased susceptibility to chronic dis-ease!